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  3. Dexamethasone-d5

Dexamethasone-d5  (Synonyms: Hexadecadrol-d5; Prednisolone F-d5)

Cat. No.: HY-14648S Purity: ≥99.0%
COA Handling Instructions

Dexamethasone-d5 (Hexadecadrol-d5) is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

For research use only. We do not sell to patients.

Dexamethasone-d5 Chemical Structure

Dexamethasone-d5 Chemical Structure

CAS No. : 358731-91-6

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1 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
5 mg USD 4850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dexamethasone-d5 (Hexadecadrol-d5) is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

397.49

Formula

C22H24D5FO5

CAS No.
SMILES

C[[email protected]@]12[[email protected]](C(C([2H])(O)[2H])=O)(O)[[email protected]](C)C[[email protected]@]1([H])[[email protected]]3([H])CC([2H])([2H])C4=C([2H])C(C=C[[email protected]]4(C)[[email protected]@]3(F)[[email protected]@H](O)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dexamethasone-d5
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HY-14648S
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