Art. -Nr.: HY-14648C

Dexamethasone (Water Soluble)

(Synonyms: Dexamethasone cyclodextrin complex)

386 Cited Publications

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Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research.(Sale size is the weight of dexamethasone)

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Reinheit: 98.87%
CAS. Nr.: 50-02-2

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dexamethasone (Water Soluble) Chemical Structure

CAS. Nr.: 50-02-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (386)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Note:
Product is approximately 65 mg of Dexamethasone per gram containing a balance of Methyl-β-cyclodextrin (HY-101461). Solubility in H2O: ≥ 100 mg/mL indicates that 100 mg of the weighed total product (not the effective weight) dissolves in 1 mL of water.

Dexamethasone (Hexadecadrol) regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response^[1].
Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC₅₀ of 2.2 nM. Dexamethasone (EC₅₀=36 nM) induces transcription of the β₂-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC₅₀=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Based on blood and multi-tissue concentration-time profiles of Dexamethasone (DEX), no significant sex differences were found in its tissue distribution. Blood cell to plasma partitioning (0.664) and plasma free fraction (0.175) were moderate, with widespread distribution in the liver (Kp=6.76). Possibly due to P-glycoprotein-mediated efflux, the concentration of DEX in the brain is very low compared to the expected high permeability^[5].
Dexamethasone (DEX) can be used in animal modeling to construct models of muscle atrophy, hypertension and depression.

1. Induction of muscle atrophy^[6]^[7]

Background

Glucocorticoids are important mediators of skeletal muscle protein degradation and upregulation of the ubiquitin-proteasome pathway. Dexamethasone induces tibialis anterior muscle protein degradation by binding to the glucocorticoid receptor, resulting in muscle atrophy.

Specific Modeling Methods

Mice: C57BL/6 • male • 6-week-old
Administration: 5 mg/kg • ip • once daily for 2 weeks

Modeling Indicators

Molecular changes: Increased indicators: C₂C₁₂ ubiquitin ligase, MuRF1, Atrogin-1, Cbl-b, p-Foxo1, p-Foxo3a. Resulted C₂C₁₂ myotube protein degradation, and Glucocorticoid receptor translocation to the nucleus

Phenotypic observation: Decreased indicators: The weight of the anterior muscles, gastrocnemius, quadriceps and soleus muscles. The ratio of skeletal muscle to body weight decreases.

Correlated Product(s): Betamethasone (HY-13570)

Opposite Product(s): Glabridin (HY-N0393)

2. Induction of hypertension^[8]^[9]

Background

The underlying mechanisms that induce hypertension (HT) are unknown.

Specific Modeling Methods

Rat: Sprague-Dawley • Male • 200-300 g
Administration: 20 μg • sc • once daily from days 5 to 16 • control rats: saline with 0.1 mL/100 g/day from days 1 to 16 (po) or 0.2 mL/rat/day (sc).

Dog: 10.1-19.1 kg • average=13.7 kg
Administration: 0.5 mg/kg • po • once daily for 10 days

Modeling Indicators

Hemodynamics: MAP, systolic blood pressure, diastolic blood pressure, TPR levels increased in central hemodynamics. Total peripheral resistance, blood pressure, atrial natriuretic peptide, and the pressor response to norepinephrine, are significantly increased in Systemic and renal hemodynamics.

Behavior: The dog showed obvious natriuresis and diuresis.

Opposite Product(s): Saralasin (HY-P0205); Prazosin (HY-B0193)

3. Induction of depressive behavior^[10]^[11]

Background

Astrocytes are a key feature of major depressive disorder (MD), and reduced expression by glucocorticoids results in reduced astrocyte numbers. Long-term treatment with Dexamethasone can cause a series of depression-like symptoms in rodents.

Specific Modeling Methods

Rat: Sprague-Dawley • Male • 200-250 g
Administration: 1 mg/kg • po • once daily every other day for 5 months

Note

(1) Prepare a 3% (w/v) treatment solution and filter through a 0.45 μm cellulose acetate filter.
(2) Rats should not be exposed to any other water source for 4 days before starting treatment.
(3) On the 4th day, change the treatment solution to water and feed for 3 days to allow the mice to recover temporarily. Weigh and conduct behavioral experiments on day 7.

Mice: C57BL/6 • Male • 9-10 weeks old • 23-25 g
Administration: 4 mg/kg • ip • once dailly for 21 days

Modeling Indicators

Metabolism changes: Serum cortisol levels in rats ↑.

Behavior: Immobility time during the forced swim test (FST) &uarr. Preference for sucrose &darr in the sucrose preference test.

Opposite Product(s): Amitriptyline (HY-B0527)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 50-02-2
Appearance Solid
Color Off-white to light yellow
SMILES

[Dexamethasone (Water Soluble)]
Synonyms

Dexamethasone cyclodextrin complex
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (386)

All 2D/3D Cell Culture and DifferentiationIn Vivo Efficacy StudyRT-PCRBio/Physico-chemical AssayHistological Imaging/StainingIFWBCell Proliferation/Viability Assay

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Cell

p53 safeguards chemical reprogramming of human somatic cells toward pluripotency. [Abstract]

2026 Jun 11;189(12):3541-3552.e18. PMID: 41999746
Cell

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery. [Abstract]

2026 Feb 19;189(4):1086-1107.e32. PMID: 41605209
Cell

The enteric nervous system relays psychological stress to intestinal inflammation. [Abstract]

2023 Jun 22;186(13):2823-2838.e20. PMID: 37236193

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Cell. 2023 Jun 22;186(13):2823-2838.e20. [Abstract]

Whole-mount IF staining for HuC/D, GFAP and pSTAT3 (arrows indicate pSTAT3+ nuclei) (P), and quantification of pSTAT3+ enteric glia cell nuclei normalized to the GFAP+ area (Q) after 7 days of stress or dexamethasone treatment.
Nat Genet

MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch. [Abstract]

2024 Apr;56(4):663-674. PMID: 38454021

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Apr;56(4):663-674. [Abstract]

Dexamethasone (Dex) (2 h) increases MYC expression in BT549 cells.
Bioact Mater

Dynamic hydrogels orchestrate the differentiation fate of mesenchymal stem cells through epigenetic regulation of SETD7 to accelerate bone defect repair. [Abstract]

2026 Feb 11:61:136-149. PMID: 41716674
Bioact Mater

Imidazole functionalized photo-crosslinked aliphatic polycarbonate drug-eluting coatings on zinc alloys for osteogenesis, angiogenesis, and bacteriostasis in bone regeneration. [Abstract]

2024 May 6:37:549-562. PMID: 38756420
J Extracell Vesicles

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect. [Abstract]

2025 Sep;14(9):e70162. PMID: 40919882
Bone Res

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]

2025 Mar 3;13(1):30. PMID: 40025004
Bone Res

Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis. [Abstract]

2025 Jan 26;13(1):18. PMID: 39865068

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

Effect of Dexamethasone (DEX) on the proliferation of MC3T3-E1 cells was determined by CCK-8 assay after 2 days of stimulation.
Adv Funct Mater

2025 Dec 5.
Adv Funct Mater

2025 May 22.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2025 May 22.

BMSCs at 80% confluence were induced with an osteogenic medium consisting of DMEM/F-12, 10% FBS, 10 nm Dexamethasone, 10 mm β-glycerophosphate, and 50 µg/mL ascorbic acid. The induction medium was replaced every 3 days. Alizarin red and ALP staining results of BMSCs on day 14.
Adv Funct Mater

2025 Apr 21.
Nat Commun

Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming. [Abstract]

2025 Aug 26;16(1):7954. PMID: 40858606
Exp Mol Med

Hepatocyte estrogen-related receptor α modulates a gluconeogenic-epigenetic crosstalk counteracting MASLD/MASH progression. [Abstract]

2026 May;58(5):1536-1555. PMID: 42104013
ACS Nano

Hybrid Biomembrane-Functionalized Nanorobots Penetrate the Vitreous Body of the Eye for the Treatment of Retinal Vein Occlusion. [Abstract]

2025 Mar 4;19(8):7728-7741. PMID: 39964811
ACS Nano

Intracellularly Synthesized Artificial Exosome Treats Acute Lung Injury. [Abstract]

2024 Aug 13;18(32):21009-21023. PMID: 39087239

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Aug 13;18(32):21009-21023. [Abstract]

The ALI mice were intratracheally treated with PBS, 5 mg/kg VER, VER-MSNs (equivalent to 5 mg/kg VER), EVM (equivalent to 5 mg/kg VER), and 5 mg/kg Dexamethasone (DXM) as the positive control, respectively. Representative images of lung samples in EBA extravasation assay. The Evans Blue albumin (EBA) extravasation assay confirmed that the treatment with EVM prominently reversed the exacerbated permeability in the ALI mice, which was considerably similar to the treatment with DXM.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Aug 13;18(32):21009-21023. [Abstract]

The ALI mice were intratracheally treated with PBS, 5 mg/kg VER, VER-MSNs (equivalent to 5 mg/kg VER), EVM (equivalent to 5 mg/kg VER), and 5 mg/kg Dexamethasone (DXM) as the positive control, respectively. Histological analysis of lung tissues.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Aug 13;18(32):21009-21023. [Abstract]

The ALI mice were intratracheally treated with PBS, 5 mg/kg VER, VER-MSNs (equivalent to 5 mg/kg VER), EVM (equivalent to 5 mg/kg VER), and 5 mg/kg Dexamethasone (DXM) as the positive control, respectively. Overall survival.
ACS Nano

Multifunctional Hydrogel Eye Drops for Synergistic Treatment of Ocular Inflammatory Disease. [Abstract]

2023 Dec 26;17(24):25377-25390. PMID: 37890030
Neuron

Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders. [Abstract]

2025 Oct 10:S0896-6273(25)00706-8. PMID: 41075784
Metabolism

Prevention of insulin-induced lipohypertrophy by coadministration of a low dose of high-affinity PI3K inhibitors. [Abstract]

2025 Jul:168:156252. PMID: 40169086
Redox Biol

The protective role of adipogenic lineage precursors in maintaining bone marrow redox homeostasis in a mouse model of prenatal dexamethasone exposure. [Abstract]

2025 Oct:86:103820. PMID: 40845776

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Oct:86:103820. [Abstract]

qPCR analysis of the effect of Dexamethasone (250 nM; 12-48 h) on Fbln5 mRNA expression in 3T3-L1 preadipocytes. The results showed that Dexamethasone treatment significantly reduced Fbln5 expression.
Nat Chem Biol

Nuclear m6A modification regulates satellite transcription and chromosome segregation. [Abstract]

2025 May 22. PMID: 40404899
Gut Microbes

The microbial metabolite desaminotyrosine is a potent antiobesity agent with potential effects on white adipose tissue remodeling in mice. [Abstract]

2025 Dec 31;17(1):2587400. PMID: 41340566

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec 31;17(1):2587400. [Abstract]

3T3-L1 preadipocytes were exposed to DAT (1 or 5 mM) throughout both the differentiation induction (days 0−4) and maintenance phases (days 4−9). 3T3-L1, nondifferentiated; Ctrl, differentiated without DAT; 1 mM DAT, differentiated with 1 mM DAT; 5 mM DAT, differentiated with 5 mM DAT. 3T3-L1 cells were grown to full confluence in full growth media containing DMEM and antibiotic-antimycotic. Then the cells were incubated in differentiation induction media [i.e., full growth media plus 2 µg/mL Dexamethasone, 500 µM IBMX, and 5 µg/mL insulin. The media was refreshed every other day for a total of four days. After that, the cells were kept in maintenance medium (full growth media supplemented with 10 µg/mL insulin) for five more days. Representative images of Oil Red O-stained 3T3-L1-derived adipocytes 9 days after differentiation under the indicated conditions.
J Nanobiotechnology

Suppression of senescent metabolism of adipose tissue by rebalancing mitochondrial homeostasis via a selective drug delivery system. [Abstract]

2026 Jun 2. PMID: 42231423
J Nanobiotechnology

TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy. [Abstract]

2025 May 30;23(1):398. PMID: 40448086

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 30;23(1):398. [Abstract]

20–22 g male BALB/c mice were randomly divided into 5 groups for the experiment. Except the control group, normal saline, free Dexamethasone (Dex, 2 mg/kg), Dex@NBs (loading 1 mg/kg Dex) or Dex@NBs-TRPC6 (loading 1 mg/kg Dex) were administered by tail vein starting at Day 1 post-ADR injection, and continued every 2 days, for a total of 7 doses. After 7 times of injection, urine was collected on Day 14. Albuminuria (urine albumin-to-creatinine ratio) was determined in control group, ADR + NS group and three Dex-treated ADR groups. n = 9–10 mice per group.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 30;23(1):398. [Abstract]

20–22 g male BALB/c mice were randomly divided into 5 groups for the experiment. Except the control group, normal saline, free Dexamethasone (Dex, 2 mg/kg), Dex@NBs (loading 1 mg/kg Dex) or Dex@NBs-TRPC6 (loading 1 mg/kg Dex) were administered by tail vein starting at Day 1 post-ADR injection, and continued every 2 days, for a total of 7 doses. Representative kidney images of PAS staining. Upper: glomerular morphology, scale bar = 20 μm; Lower: tubule-interstitial morphology, scale bar = 50 μm.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 30;23(1):398. [Abstract]

20–22 g male BALB/c mice were randomly divided into 5 groups for the experiment. Except the control group, normal saline, free Dexamethasone (Dex, 2 mg/kg), Dex@NBs (loading 1 mg/kg Dex) or Dex@NBs-TRPC6 (loading 1 mg/kg Dex) were administered by tail vein starting at Day 1 post-ADR injection, and continued every 2 days, for a total of 7 doses. Upper: immunofluorescence staining of WT1 expressed in nuclei of mouse podocytes, scale bar = 20 μm. Lower: immunofluorescence staining of podocin expressed along the glomerular basement membrane, scale bar = 20 μm.
J Nanobiotechnology

Precision 3D printed meniscus scaffolds to facilitate hMSCs proliferation and chondrogenic differentiation for tissue regeneration. [Abstract]

2021 Dec 2;19(1):400. PMID: 34856996
Nucleic Acids Res

COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. [Abstract]

2021 Jan 8;49(D1):D1113-D1121. PMID: 33166390
Theranostics

Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury. [Abstract]

2025 Aug 16;15(17):9131-9158. PMID: 40963901
Acta Pharm Sin B

2026 May 15.
Acta Pharm Sin B

2025 Nov 13.
Acta Pharm Sin B

Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation. [Abstract]

2025 Oct;15(10):5277-5293. PMID: 41132839
Acta Pharm Sin B

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]

2024 Aug;14(8):3493-3512. PMID: 39220878
J Biomed Sci

USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression. [Abstract]

2025 May 30;32(1):54. PMID: 40448065
Adv Sci (Weinh)

Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis. [Abstract]

2025 Dec 16:e10368. PMID: 41400028
Adv Sci (Weinh)

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization. [Abstract]

2025 Nov 14:e14514. PMID: 41236855
Adv Sci (Weinh)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression. [Abstract]

2025 Nov 21:e08472. PMID: 41268703
Adv Sci (Weinh)

Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment. [Abstract]

2025 Oct 28:e16569. PMID: 41147460
Adv Sci (Weinh)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid-Induced Osteoporosis by Suppressing Osteocyte Ferroptosis. [Abstract]

2025 Aug;12(31):e14902. PMID: 40444470
Adv Sci (Weinh)

Asprosin-FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development. [Abstract]

2025 Jun;12(21):e2415846. PMID: 40231957
Adv Sci (Weinh)

A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects. [Abstract]

2025 Jan;12(1):e2406766. PMID: 39487959
Adv Sci (Weinh)

Near-Infrared-Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver. [Abstract]

2022 Sep;9(26):e2202505. PMID: 35853243
Adv Sci (Weinh)

Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis. [Abstract]

2022 Jan;9(3):e2102435. PMID: 34825505
Cell Rep Med

Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy. [Abstract]

2026 Mar 17;7(3):102644. PMID: 41763214
Cell Rep Med

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer. [Abstract]

2025 Jul 15;6(7):102215. PMID: 40609538
Cell Rep Med

scRNA-seq reveals an immune microenvironment and JUN-mediated NK cell exhaustion in relapsed T-ALL. [Abstract]

2025 May 20;6(5):102098. PMID: 40306275
Sci Adv

DLX2 acts as a pioneer factor and drives Msx1+ ectomesenchyme formation from embryonic stem cells. [Abstract]

2026 Jan 16;12(3):eaea0685. PMID: 41533791
Biomaterials

Epidermal and dermal cell-composed organospheres to assess microplastic-induced skin toxicity. [Abstract]

2026 Jan:324:123513. PMID: 40582217
Biomaterials

Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway. [Abstract]

2020 Feb:232:119730. PMID: 31918224

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb:232:119730. [Abstract]

Raw264.7 macrophages induced with LPS (1 μg/mL) for 6 h. Then cellular uptake of Cy5-labeled Dexamethasone (Dex)/OxiαCD NPs or Dex/FA-Oxi-αCD NPs is assessed using confocal laser scanning microscopy at various times.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb:232:119730. [Abstract]

Raw264.7 cells are treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h, the optical density values at 450 nm were measured and the cell viability was determined by CCK-8 assay.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb:232:119730. [Abstract]

Raw264.7 cells are treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h, mRNA level of iRhom2 in Raw264.7 cells is detected by quantitative real-time PCR. Data are presented by the relative amount of mRNA normalized by GAPDH.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb:232:119730. [Abstract]

Western blot analysis of iRhom2, TNF-α, and BAFF expression in Raw264.7 cells treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h.
Carbohydr Polym

Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice. [Abstract]

2023 Jan 1:299:120179. PMID: 36876794

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2023 Jan 1:299:120179. [Abstract]

Western blotting analysis of Itgb2 levels in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2023 Jan 1:299:120179. [Abstract]

mRNA levels of Itgb2 in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2023 Jan 1:299:120179. [Abstract]

Immunofluorescence analysis of Itgb2 in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.
Mol Biomed

5-methoxytryptamine improves hepatic inflammation and insulin resistance in a macrophage C-X-C motif chemokine ligand 14 dependent manner. [Abstract]

2026 Jun 28;7(1):101. PMID: 42365576
Chem Eng J

2026 Jan 24;530:173330.
Chem Eng J

2025 Oct 8;524:169421.
Chem Eng J

2023 Aug 6, 145212.
J Control Release

Integrin/CD44-targeted liposomes remodel the pulmonary microenvironment to alleviate acute exacerbation of pulmonary fibrosis. [Abstract]

2026 Jan 10:389:114427. PMID: 41265642
Small

Vertex-Integrated Tetrahedral DNA Nanoframe Enhances miR-143-3p Delivery for Osteoarthritis Therapy. [Abstract]

2026 Mar 11:e11570. PMID: 41808575
Small

Transport of Adoptive Cell Transfers With Magnetic Helical Microrobots. [Abstract]

2025 Sep 5:e05946. PMID: 40911713
Small

Bubble-Based Microrobots with Rapid Circular Motions for Epithelial Pinning and Drug Delivery. [Abstract]

2023 Aug;19(32):e2300409. PMID: 37058137
J Allergy Clin Immunol

Brg1-imprinted chromatin status controls effector and memory group 2 innate lymphoid cell metabolism to exacerbate allergic lung inflammation. [Abstract]

2025 Sep 17:S0091-6749(25)00948-0. PMID: 40972980
J Immunother Cancer

Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway. [Abstract]

2024 Sep 4;12(9):e009318. PMID: 39237260
Cell Commun Signal

Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway. [Abstract]

2025 Feb 5;23(1):65. PMID: 39910568
Phytomedicine

Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation. [Abstract]

2026 Jul:156:158267. PMID: 42134228
Phytomedicine

Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition. [Abstract]

2026 Jun:155:158147. PMID: 41966024
Phytomedicine

Dihydroartemisinin alleviates sepsis-associated encephalopathy by reducing microglial iron accumulation and mitochondrial dysfunction via HIF1A/HMOX1 pathway. [Abstract]

2025 Nov 25:148:157413. PMID: 41135271
Phytomedicine

Perillyl alcohol ameliorates high-fat diet-induced obesity in mice by modulating gut microbiota and activating IRF4-mediated brown fat thermogenesis. [Abstract]

2025 Nov 25:148:157400. PMID: 41138577
Phytomedicine

Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages. [Abstract]

2025 Oct:146:157091. PMID: 40768810
Phytomedicine

Euchrenone A10 attenuates septic lung injury though S100A8/A9-dependent TLR4/MyD88/NF-κB signaling. [Abstract]

2025 Sep 27:148:157336. PMID: 41038141
Phytomedicine

Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice. [Abstract]

2025 Sep 24:148:157306. PMID: 41046685
Phytomedicine

Raspberry ketone alleviates radiation-induced lung injury through the STAT2-P2X7r/NLRP3 signaling pathway. [Abstract]

2025 Sep:145:156984. PMID: 40544736
Phytomedicine

Tanshinone IIA attenuates sepsis-induced lung injury by reducing VEGFR2/PI3K/AKT-driven mitochondrial disruption dependent apoptosis. [Abstract]

2025 Sep:145:156957. PMID: 40544732
Phytomedicine

Dihydromyricetin alleviates lipid peroxidation-induced Pyroptosis by inhibiting xCT ubiquitination and degradation in experimental COPD model. [Abstract]

2025 Aug:144:156929. PMID: 40483790
Phytomedicine

Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage. [Abstract]

2025 Jul:142:156698. PMID: 40397999
Allergy

Ficolin-A Protects Against Allergic Asthma via Suppressing ILC2-Drived Type 2 Inflammation. [Abstract]

2025 Jul 25. PMID: 40708471
Phytomedicine

Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of Pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways. [Abstract]

2025 Jun:141:156663. PMID: 40133026
Phytomedicine

Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway. [Abstract]

2025 Apr:139:156491. PMID: 39955824
Phytomedicine

Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD. [Abstract]

2025 Apr:139:156508. PMID: 40031093
Phytomedicine

Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis. [Abstract]

2025 Feb:137:156362. PMID: 39809030
Phytomedicine

Shikonin ameliorated LPS-induced acute lung injury in mice via modulating MCU-mediated mitochondrial Ca2+ and macrophage polarization. [Abstract]

2024 Dec:135:156043. PMID: 39366155
Phytomedicine

The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K/AKT pathway. [Abstract]

2024 Dec:135:156168. PMID: 39486109
Phytomedicine

Targeting macrophagic RasGRP1 with catechin hydrate ameliorates sepsis-induced multiorgan dysfunction. [Abstract]

2024 Jul 25:130:155733. PMID: 38759314
Phytomedicine

Amelioration of lipid accumulations and metabolism disorders in differentiation and development of 3T3-L1 adipocytes through mulberry leaf water extract. [Abstract]

2022 Apr:98:153959. PMID: 35134622
J Pharm Anal

2025 Aug 9.
Chin Herb Med

Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. [Abstract]

2024 Apr 30;16(3):422-434. PMID: 39072201
Adv Healthc Mater

Porous Microspheres Loading Small Molecule Targeting REV-ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration. [Abstract]

2025 Sep;14(23):e2500867. PMID: 40557559
Adv Healthc Mater

Novel Drug-Testing Platform for Vascular Injury-induced Intimal Hyperplasia Using a Microphysiological System. [Abstract]

2025 Aug 11:e00602. PMID: 40787716
Mater Today Bio

A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]

2025 Jun 21:33:102009. PMID: 40673132
Mater Today Bio

The design of strut/TPMS-based pore geometries in bioceramic scaffolds guiding osteogenesis and angiogenesis in bone regeneration. [Abstract]

2023 May 18:20:100667. PMID: 37273795
Journal of Future Foods

2026 May 26.
Acta Pharmacol Sin

Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma. [Abstract]

2025 Mar 25. PMID: 40133626
Acta Biomater

The synergistic regulation of chondrogenesis by collagen-based hydrogels and cell co-culture. [Abstract]

2022 Dec:154:194-211. PMID: 36309191
Acta Pharmacol Sin

Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays. [Abstract]

2022 Sep;43(9):2429-2438. PMID: 35110698
Acta Pharmacol Sin

Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]

2021 Jan;42(1):108-114. PMID: 32398685
Acta Pharmacol Sin

6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. [Abstract]

2020 Jan;41(1):10-21. PMID: 31213669
Collagen Leather

2025 Nov 19，7(1):39.
J Cachexia Sarcopenia Muscle

Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals its novel function in promoting muscle atrophy. [Abstract]

2022 Aug;13(4):2017-2030. PMID: 35592920

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]

qRT‐PCR results show that DEX (DEX; 25 μg/g ; once a day; for 10 days)-induced myotube atrophy can increase the expression levels of MuRF1, Atrogin‐1, FoxO3a, SYISL, and miR‐205‐5p, decrease the expression levels of miR‐23a‐3p and miR‐103‐3p, but does not affect the expression level of SYNPO2.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]

Western blotting results show that SYISL overexpression can further promote protein ubiquitination levels in Dexamethasone (DEX; 25 μg/g ; once a day; for 10 days)-induced muscular atrophy. Muscle atrophy is induced by intraperitoneal injection of DEX for 10 days in 3‐month‐old wild‐type and KO mice, respectively.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]

Representative photographs of H&E and Lamin immunofluorescence staining for WT and KO TA muscles. Quantification of five independent experiments shows that knockout of SYISL alleviates muscle weight loss caused by Dexamethasone (DEX; 25 μg/g ; once a day; for 10 days)-induced muscle atrophy.
J Orthop Translat

The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss. [Abstract]

2024 Oct 4:49:82-95. PMID: 39430128
J Transl Med

Transcription factor, E4BP4, inhibits autophagy and apoptosis in multiple myeloma and promotes the HDAC3-mediated suppression of the Beclin1 promoter to reduce dexamethasone sensitivity. [Abstract]

2026 Jun 22;24(1):806. PMID: 42332765
J Transl Med

Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis. [Abstract]

2024 Dec 3;22(1):1095. PMID: 39623468
Proc Natl Acad Sci U S A

Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection. [Abstract]

2026 Jan 13;123(2):e2530209123. PMID: 41499397
Oncogene

Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway. [Abstract]

2021 Sep;40(35):5367-5378. PMID: 34272474

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]

The GR expression of 4T1 cells treated with Dexamethasone (100 nM)/Mifepristone for 48 h.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]

The migration assay of 4T1 cells in different condition. 4T1 cells were pretreated with 100 nM Dexamethasone (Dex) for 48 h and then are used for Transwell.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]

For in situ treatment in the 4T1 tumor model, Dexamethasone (Dex; 3 mg/kg) is performed every three days by gavage twice/day. The expression of Nedd4l, p-Nedd4l, Smad2 and p-Smad2 after SGK1 knockout.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]

4T1 cells are treated with Dexamethasone (Dex; 100 nM)/GSK650394 in vitro for 48 h before inoculation via intravenous injection.
Int J Surg

Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis. [Abstract]

2025 Jul 2. PMID: 40607908
JHEP Rep

2026 May 5.
Int J Biol Macromol

Circular RNA circPTPN3 facilitates duck hepatitis A virus type 3 (DHAV-3) infection by reducing miR-130b-5p function in duck. [Abstract]

2025 Dec;334(Pt 2):149132. PMID: 41265597
BMC Med

The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression. [Abstract]

2025 May 30;23(1):316. PMID: 40442660
Small Methods

Plasma Membrane-Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis. [Abstract]

2025 Jan;9(1):e2400660. PMID: 39036830
Int J Nanomedicine

A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases. [Abstract]

2024 Nov 21:19:12369-12387. PMID: 39606561
Int J Biol Macromol

Phyllostachys nigra (Lodd. ex Lindl.) derived polysaccharide with enhanced glycolipid metabolism regulation and mice gut microbiome. [Abstract]

2023 Dec 2;257(Pt 1):128588. PMID: 38048922
Int J Mol Med

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis. [Abstract]

2026 Aug;58(2):208. PMID: 42246175
Int J Mol Med

Sophoricoside attenuates autoimmune‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway. [Abstract]

2023 Sep;52(3):78. PMID: 37477163
Plant Physiol

Ascorbate peroxidase 1 allows monitoring of cytosolic accumulation of effector-triggered reactive oxygen species using a luminol-based assay. [Abstract]

2023 Feb 12;191(2):1416-1434. PMID: 36461917
Antioxidants (Basel)

Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways. [Abstract]

2021 Aug 24;10(9):1333. PMID: 34572964
Phytother Res

Chrysophanol Attenuates Glucocorticoid-Induced Osteoporosis by Targeting the E74-Like Factor 5/Osteoglycin-Regulated PI3K/AKT/mTOR Signaling Axis: An In Vitro and In Vivo Study. [Abstract]

2026 Apr;40(4):2143-2165. PMID: 41657040
Phytother Res

Scutellarin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting M1 Macrophage Polarization via the GBP2/JAK2/STAT3 Signaling Pathway. [Abstract]

2025 Sep 18. PMID: 40968089
Phytother Res

Delay the progression of glucocorticoid-induced osteoporosis: Fraxin targets ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2024 Nov;38(11):5203-5224. PMID: 39192711
Mater Today Adv

2026 Feb 10.
Free Radic Biol Med

Chronic stress-induced steroids mediate mitochondrial fission and fibrosis in the trabecular meshwork via the MIEF1-MAOA complex. [Abstract]

2026 Mar 16:246:316-333. PMID: 41579974
Free Radic Biol Med

Ferulic acid attenuates Sarcopenia progression by inhibiting peroxisomal ACOX1. [Abstract]

2025 Aug 13:240:183-196. PMID: 40816648
Free Radic Biol Med

Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression. [Abstract]

2024 Sep:222:229-243. PMID: 38906233
Free Radic Biol Med

Lactoferrin ameliorated obesity-induced endothelial dysfunction by inhibiting the Tak1/IL-18/eNOS pathway between PVAT and vascular endothelium. [Abstract]

2024 Feb 20:212:309-321. PMID: 38159893
Free Radic Biol Med

Therapeutic effect of SIRT3 on glucocorticoid-induced osteonecrosis of the femoral head via intracellular oxidative suppression. [Abstract]

2021 Nov 20;176:228-240. PMID: 34260898
Clin Transl Med

CRISPRa-based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning. [Abstract]

2023 Jul;13(7):e1326. PMID: 37462619
ACS Appl Mater Interfaces

Magnesium-Chelating Vitamin C Nanostructures Induce p38 MAPK Vitcylation for Hepatic Fibrosis Therapy. [Abstract]

2026 Apr 8;18(13):18781-18792. PMID: 41871182
Stem Cell Res Ther

Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging. [Abstract]

2024 Nov 28;15(1):456. PMID: 39609885
Stem Cell Res Ther

Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation. [Abstract]

2023 Dec 20;14(1):333. PMID: 38115136
Aging Cell

Aging-Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL-1α-Mediated Osteoclastogenesis. [Abstract]

2026 Jun;25(6):e70582. PMID: 42259765
Cell Rep

Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling. [Abstract]

2025 Dec 11;44(12):116678. PMID: 41385373
Curr Biol

A noradrenergic pathway for the induction of pain by sleep loss. [Abstract]

2024 Jun 17;34(12):2644-2656.e7. PMID: 38810638
Cell Rep

A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]

2024 Feb 17;43(2):113804. PMID: 38368612
Cell Prolif

Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. [Abstract]

2024 Dec;57(12):e13720. PMID: 39045886
Br J Pharmacol

Ginsenoside compound K up-regulates β-subunits of long-chain L-3-hydroxyacyl-CoA (HADHB) to promote fatty acid oxidation recovery and improve the balance of macrophage polarization in mice with ulcerative colitis. [Abstract]

2026 Jul;183(13):3633-3650. PMID: 41918496
Brain Behav Immun

Chronic psychological stress-orchestrated glial-ILC3 circuit exacerbates intestinal inflammation and depression. [Abstract]

2025 Nov:130:106118. PMID: 40987409
Br J Pharmacol

Protopanaxadiol alleviates neuropathic pain by spinal microglial dynorphin A expression following glucocorticoid receptor activation. [Abstract]

2021 Aug;178(15):2976-2997. PMID: 33786848

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Aug;178(15):2976-2997. [Abstract]

Primary microglial cells incubated with Protopanaxadiol (100 μM), Dexamethasone (100 nM) or Dexamethasone-BSA (10 nM) show remarkable dynorphin A expression. Pretreatment with Dexamethasone-21-mesylate for 0.5 h completely abolished Protopanaxadiol-, Dexamethasone- or Dexamethasone-BSA-stimulated dynorphin A expression.
Transl Psychiatry

PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice. [Abstract]

2021 Mar 26;11(1):185. PMID: 33771972
Chin Med

Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition. [Abstract]

2025 Dec 10;20(1):215. PMID: 41372934
J Med Chem

Discovery of Chromone Derivatives as Selective BLT1 Inhibitors for Alleviating Acute Lung Injury and Sepsis. [Abstract]

2026 Feb 26;69(4):4361-4390. PMID: 41696851
J Med Chem

Discovery of Novel Nonsteroidal SGRMs of Sulfonamide-2-Oxo-Tetrahydroquinoline Derivatives by Carbonyl Migration. [Abstract]

2026 Jan 22;69(2):1507-1529. PMID: 41490153
J Med Chem

Discovery of Novel Neo-Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ. [Abstract]

2024 Sep 12;67(17):15738-15755. PMID: 39185622
J Med Chem

Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors. [Abstract]

2023 Jan 12;66(1):473-490. PMID: 36576395
J Med Chem

Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. [Abstract]

2022 Dec 8;65(23):15710-15724. PMID: 36399795
J Med Chem

Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration. [Abstract]

2021 Mar 11;64(5):2725-2738. PMID: 33619967
J Med Chem

Discovery of 4-Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton's Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis. [Abstract]

2019 Jul 25;62(14):6561-6574. PMID: 31260299
Atherosclerosis

C-reactive protein exacerbates high-fat diet-induced atherosclerosis via a liver-to-vessel axis that determines therapeutic efficacy of atorvastatin. [Abstract]

2026 Jan:412:120594. PMID: 41319376
Chem Mater

2017, 29(19):8221-8238.
Redox Rep

Scutellarin suppresses Mycobacterium tuberculosis-induced pyroptosis in macrophages by inhibiting the HIF-1α-mediated Warburg effect. [Abstract]

2025 Dec;30(1):2565861. PMID: 41051976
J Ethnopharmacol

Attenuation of acute lung injury by Lonicerae Japonicae Flos extracts is associated with the rebalancing of Th1/Th2/Th17/Treg cells in lungs and colons. [Abstract]

2026 Aug 10:367:121740. PMID: 42009238
J Ethnopharmacol

An active marker-based strategy for Anti-inflammatory Enhancement of Qiangli Pipa Syrup. [Abstract]

2026 Aug 10:367:121739. PMID: 42019737
J Ethnopharmacol

Linggan Wuwei Jiangxin Decoction attenuates chronic obstructive pulmonary disease via modulation of the AGE/RAGE signaling pathway. [Abstract]

2026 Jun 12:364:121483. PMID: 41791616
J Ethnopharmacol

Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation. [Abstract]

2026 Feb 28:357:120903. PMID: 41242509
J Ethnopharmacol

Discovery of ganodecalone A, from Ganoderma calidophilum for the treatment of acute gastric ulcers by binding to ALOX5 via the MAPK/NF-κB/iNOS signaling. [Abstract]

2025 Jul 24:351:120082. PMID: 40482864
J Ethnopharmacol

Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome. [Abstract]

2025 Jan 10:336:118661. PMID: 39159837
J Ethnopharmacol

Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway. [Abstract]

2025 Jan 30;337(Pt 1):118831. PMID: 39278292
J Ethnopharmacol

Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]

2025 Jan 31:340:119128. PMID: 39617084
J Ethnopharmacol

In vivo and in vitro study on the regulatory mechanism of XiaoChaiHu decoction on PANoptosis in sepsis-induced cardiomyopathy. [Abstract]

2025 Jan 10:336:118740. PMID: 39197800
J Ethnopharmacol

Molecular mechanism of Gan-song Yin inhibiting the proliferation of renal tubular epithelial cells by regulating miR-21-5p in adipocyte exosomes. [Abstract]

2024 Mar 1:321:117530. PMID: 38043753
J Ethnopharmacol

Prinsepia utilis Royle leaf extract: Ameliorative effects on allergic inflammation and skin lesions in allergic contact dermatitis and polyphenolic profiling through UPLC-MS/MS coupled to chemometric analysis. [Abstract]

2023 Apr 6:305:116093. PMID: 36603785
J Ethnopharmacol

23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways. [Abstract]

2023 Jan 10:300:115725. PMID: 36115602
J Ethnopharmacol

The water extract of "Jiao Mei Gu" attenuates the lipopolysaccharide-induced inflammatory response via inhibiting NF-κB activity in mice. [Abstract]

2020 Sep 15:259:112882. PMID: 32325181
J Agric Food Chem

Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway. [Abstract]

2025 Jun 4;73(22):13891-13901. PMID: 40404584
Eur J Med Chem

Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents. [Abstract]

2024 Nov 5:277:116773. PMID: 39163779
Eur J Med Chem

Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway. [Abstract]

2023 Oct 5:258:115602. PMID: 37406380
Eur J Med Chem

Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. [Abstract]

2022 Jul 5:237:114382. PMID: 35483323
Eur J Med Chem

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis. [Abstract]

2021 Dec 5:225:113743. PMID: 34403978
Ecotoxicol Environ Saf

Regulation of Parkin in Cr (VI)-induced mitophagy in chicken hepatocytes. [Abstract]

2022 Dec 15:248:114315. PMID: 36423368
Ecotoxicol Environ Saf

Gestational cadmium exposure impairs placental angiogenesis via activating GC/GR signaling. [Abstract]

2021 Aug 16:224:112632. PMID: 34411824
Biochem Pharmacol

Discovery of novel CSF1R inhibitor for triple-negative breast cancer (TNBC) treatment through TAMs reprogramming. [Abstract]

2026 Aug;250(Pt 1):117984. PMID: 42000076
Mech Ageing Dev

PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts. [Abstract]

2026 Aug:232:112215. PMID: 42320599
Cell Mol Life Sci

Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors. [Abstract]

2025 Nov 19;82(1):412. PMID: 41258103
Biochem Pharmacol

Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway. [Abstract]

2025 Jun:236:116870. PMID: 40086515
Biochem Pharmacol

20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway. [Abstract]

2020 Oct:180:114145. PMID: 32653593

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct:180:114145. [Abstract]

After C2C12 myotubes are incubated with Dexamethasone (DEX) and S-Rg3 for 24 h, myotube levels of MuRF1 and atrogin-1 are detected using Western blot analysis.

Dexamethasone (Water Soluble) purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct:180:114145. [Abstract]

Translocation of FoxO3 after treatment with S-Rg3 in DEX-treated C2C12 myotubes was investigated by immunofluorescence staining.
Life Sci

Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells. [Abstract]

2019 Mar 15:221:168-177. PMID: 30738043
Nanoscale Adv

Dexamethasone-loaded lipid-polymeric nanoparticles to improve therapy for cisplatin-induced sensorineural hearing loss. [Abstract]

2025 Nov 21. PMID: 41278499
J Mater Chem B

Oxidized chondroitin sulfate eye drops ameliorate the prognosis of fungal keratitis with anti-inflammatory and antifungal effects. [Abstract]

2022 Oct 5;10(38):7847-7861. PMID: 36070420
Drug Des Devel Ther

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways. [Abstract]

2022 Nov 15:16:3929-3946. PMID: 36411860
Cells

The Asp-Encoding Gene FBN1 Mediates Cold Adaptation in Sunite Sheep by Reprogramming Adipocyte Differentiation Towards Thermogenesis. [Abstract]

2026 Feb 11;15(4):329. PMID: 41744772
Ceram Int

2025 Nov 7.
ACS Biomater Sci Eng

Mechanoresponsive Drug Loading System with Tunable Host-Guest Interactions for Ocular Disease Treatment. [Abstract]

2022 Nov 14;8(11):4850-4862. PMID: 36214483
J Biomed Inform

From Centralized to Ad-Hoc Knowledge Base Construction for Hypotheses Generation. [Abstract]

2023 Jun:142:104383. PMID: 37196989
Commun Biol

Macrophage-derived IL-1β directs fibroblast progenitor cell fate via metabolic reprogramming in wound healing. [Abstract]

2025 Aug 27;8(1):1291. PMID: 40866544
Commun Biol

Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [Abstract]

2025 Jul 29;8(1):1127. PMID: 40730679
Commun Biol

Inhibition of inner ear macrophage phagocytosis alleviates cisplatin-induced ototoxicity. [Abstract]

2025 Jul 30;8(1):1134. PMID: 40739377
Commun Biol

Prenatal dexamethasone exposure reduces osteoprogenitor proliferation in mice via histone modifications at the Mkp-1 gene locus. [Abstract]

2024 Nov 28;7(1):1589. PMID: 39609620
Nat Prod Bioprospect

Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response. [Abstract]

2023 Oct 7;13(1):36. PMID: 37804362
Commun Biol

A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements. [Abstract]

2022 Nov 26;5(1):1295. PMID: 36435843
Eur J Pharmacol

Isoliquiritigenin ameliorates Pseudomonas aeruginosa-induced acute lung injury through inhibiting lung epithelial cell ferroptosis via PPARγ/Nrf2/GPX4 axis. [Abstract]

2026 Jul 10:1029:179018. PMID: 42178009
Pharmaceuticals (Basel)

Diosmetin Alleviates MRSA-Induced Pneumonia in Mice by Inhibiting NLRP3 Inflammasome Activation and NF-κB Signaling Pathway. [Abstract]

2026 May;19(5):674. PMID: 42198348
Eur J Pharmacol

Purmorphamine attenuates dexamethasone-induced suppression of neurite outgrowth through sonic hedgehog signaling in Neuro2a cells. [Abstract]

2026 Jan 12:1011:178434. PMID: 41349709
Eur J Pharmacol

Spinal microglial membrane glucocorticoid receptors regulate anti-hypersensitivity by stimulating dynorphin A expression. [Abstract]

2026 Jan 10:1010:178362. PMID: 41276104
Eur J Pharmacol

Doxorubicin-mediated retardation of aggresome formation enhances Carfilzomib-induced cell death synergistically by augmenting ER stress and proapoptotic signaling. [Abstract]

2025 Dec 5:1008:178303. PMID: 41183585
Adv Wound Care (New Rochelle)

Dual-Action Topical Therapy Accelerates Healing of MRSA-Infected Burn Wounds by Targeting Infection and Inflammation. [Abstract]

2025 Dec 22. PMID: 41449962
Eur J Pharmacol

Chlorogenic acid alleviates DNCB-induced atopic dermatitis by inhibiting the Akt1/NF-κB signaling pathway. [Abstract]

2025 Jul 5:998:177534. PMID: 40118327
Eur J Pharmacol

Exploring the mechanism of α-Bisabolol in the treatment of psoriasis based on network pharmacology and experimental validation. [Abstract]

2025 Jul 15:999:177433. PMID: 40089261
Eur J Pharmacol

Iguratimod, a promising therapeutic agent for COVID-19 that attenuates excessive inflammation in mouse models. [Abstract]

2025 Jun 5:996:177537. PMID: 40147575
Eur J Pharmacol

Paeonol regulates autophagy through the PI3K-AKT-mTOR signaling pathway to inhibit apoptosis of osteocytes. [Abstract]

2025 May 15:995:177427. PMID: 39988091
Cell Biol Toxicol

Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway. [Abstract]

2025 Mar 7;41(1):56. PMID: 40053226
Pharmaceuticals (Basel)

Kaempferol Mitigates Pseudomonas aeruginosa-Induced Acute Lung Inflammation Through Suppressing GSK3β/JNK/c-Jun Signaling Pathway and NF-κB Activation. [Abstract]

2025 Feb 25;18(3):322. PMID: 40143103
Pharmaceuticals (Basel)

In Vitro and In Vivo Assessment of Pharmacokinetic Profile of Peramivir in the Context of Inhalation Therapy. [Abstract]

2025 Jan 29;18(2):181. PMID: 40005995
Eur J Pharmacol

Sappanone A ameliorated imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing Mmp8 expression and IL-17 signaling pathway. [Abstract]

2024 Sep 5:978:176746. PMID: 38880219
Eur J Pharmacol

Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway. [Abstract]

2023 Jan 5:938:175425. PMID: 36442621
Int Immunopharmacol

VEGF-C silencing unlocks therapeutic synergy between MSCs and dexamethasone for osteoarthritis repair. [Abstract]

2026 Aug 1:182:116724. PMID: 42096958
Int Immunopharmacol

Se-methylselenocysteine alleviates sepsis-associated inflammation by upregulating GPX4 to inhibit macrophage ferroptosis. [Abstract]

2026 May 14:182:116851. PMID: 42134291
Int J Mol Sci

Therapeutic Potential of a Novel Stenotrophomonas maltophilia Phage XAN_XB1: Isolation, Characterization, Genome Analysis and Evaluation in Mice Model. [Abstract]

2026 Jan 18;27(2):944. PMID: 41596591
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2026 Mar 1:172:116207. PMID: 41554225
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2025 Dec 10:167:115599. PMID: 41101227
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2023 Jun 29;24(13):10838. PMID: 37446019
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2024 Aug 1:15:1413876. PMID: 39148539
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2022 Sep 26;13:997701. PMID: 36225577
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2023 May 30;28(11):4441. PMID: 37298919
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Effects of the combination of Epimedii Folium and Ligustri Lucidi Fructus on apoptosis and autophagy in SOP rats and osteoblasts via PI3K/AKT/mTOR pathway. [Abstract]

2024 Apr:173:116346. PMID: 38428312
SSRN

2024 Mar 8.
Universidad de Navarra

2024 Feb 28.
Patent

US20230404992A1.
SSRN

2023 Oct 30.
SSRN

2023 Oct 10.
SSRN

2023 Sep 11.
Comput Biol Med

Exploration of the anti-inflammatory mechanism of Lanqin oral solution based on the network pharmacology analysis optimized by Q-markers selection. [Abstract]

2023 Mar:154:106607. PMID: 36731363
Utah State University

2023 Feb 1.
Research Square Print

January 4th, 2023.
Authorea

2023 Jan 27.
bioRxiv

2023.
SSRN

2022.
Research Square Print

2022 Aug.
Heliyon

Study on the molecular mechanisms of tetrandrine against pulmonary fibrosis based on network pharmacology, molecular docking and experimental verification. [Abstract]

2022 Aug 13;8(8):e10201. PMID: 36046534
Oxid Med Cell Longev

Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance. [Abstract]

2022 Apr 14;2022:4913534. PMID: 35578727
Oxid Med Cell Longev

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling. [Abstract]

2022 Mar 3;2022:3182368. PMID: 35281469
Research Square Preprint

2021 Oct.
Front Med (Lausanne)

Amnion-Derived Mesenchymal Stromal/Stem Cell Paracrine Signals Potentiate Human Liver Organoid Differentiation: Translational Implications for Liver Regeneration. [Abstract]

2021 Sep 23:8:746298. PMID: 34631757
Patent

US20210252159A1.
Biomed Pharmacother

Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy. [Abstract]

2021 Jul:139:111590. PMID: 33865017
Research Square Preprint

2021 Jul.
Patent

US20180263995A1.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [Content Brief]

[2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 [Content Brief]

[3]. Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83. [Content Brief]

[4]. Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397.

[5]. Yoshioka Y, et al. Glabridin inhibits dexamethasone-induced muscle atrophy. Arch Biochem Biophys. 2019 Mar 30;664:157-166. [Content Brief]

[6]. Troncoso R, et al. Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance. Cell Cycle. 2014;13(14):2281-95. [Content Brief]

[7]. Ong SL, et al. Hemodynamics of dexamethasone-induced hypertension in the rat. Hypertens Res. 2009 Oct;32(10):889-94. [Content Brief]

[8]. Nakamoto H, et al. Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Clin Exp Hypertens A. 1991;13(4):587-606. [Content Brief]

[9]. Mesripour A, et al. The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair. Nutr Neurosci. 2019 Oct;22(10):744-749. [Content Brief]

[10]. Bhatt S, et al. Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. Basic Clin Pharmacol Toxicol. 2016 Jul;119(1):10-8. [Content Brief]

[11]. Song D, et al. Physiologically Based Pharmacokinetics of Dexamethasone in Rats. Drug Metab Dispos. 2020 Sep;48(9):811-818. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Dexamethasone (Water Soluble)

386 Cited Publications

100 mg Angebot einholen

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Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Dexamethasone (Water Soluble)

Dexamethasone

Rosiglitazone

IBMX

Insulin solution (human)

Mifepristone

Dexamethasone (Standard)

Dexamethasone (GMP)

Insulin (human)

L-Ascorbic acid

Etoposide

Hydrocortisone (Standard)

Metformin

Publications Citing Use of MedChemExpress (MCE) Dexamethasone (Water Soluble)

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (386)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

Dexamethasone (Water Soluble)

Dexamethasone

Rosiglitazone

IBMX

Insulin solution (human)

Mifepristone

Dexamethasone (Standard)

Dexamethasone (GMP)

Insulin (human)

L-Ascorbic acid

Etoposide

Hydrocortisone (Standard)

Metformin

Publications Citing Use of MedChemExpress (MCE) Dexamethasone (Water Soluble)

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (386)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Dexamethasone (Water Soluble) Related Classifications

HY-14648C Related Classifications

Bioz