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  3. PPAR Reactive Oxygen Species (ROS) Bacterial
  4. Glabridin

Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.

For research use only. We do not sell to patients.

CAS No. : 59870-68-7

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Based on 12 publication(s) in Google Scholar

Other Forms of Glabridin:

Glabridin Related Antibodies

Top Publications Citing Use of Products

    Glabridin purchased from MedChemExpress. Usage Cited in: Parasit Vectors. 2024 Dec 18;17(1):522.  [Abstract]

    Cytotoxicity of Glabridin on Vero cells. Glabridin demonstrated low cytotoxicity in Vero cells. Cells were exposed to increasing concentrations of Glabridin (0, 2.5, 5, 7.5, 10, and 20 µg/mL) for 24 h. Cell viability was measured using the Cell Counting Kit-8 (CCK-8) assay, with results expressed as a percentage relative to the untreated control group.

    Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167.  [Abstract]

    BMDMs were first treated with DMSO or Glabridin (Glab) (0. 5, 10, 20 μM) of various concentrations for 1 h, and then stimulated with HT-DNA or Poly(I:C) for 2 h. Whole cell lysate (WCL) was collected and immunoblotted with the indicated antibody.

    Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167.  [Abstract]

    BMDMs were treated with DMSO or Glabridin (Glab) (0. 5, 10, 20 μM) of various concentrations for 1 h, and then stimulated with HT-DNA for 4 h. The expression of IFN-β, IL-6 and TNF-α mRNA level were detected by quantitative polymerase chain reaction (qPCR) assay.

    Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167.  [Abstract]

    Glabridin (20, 40 mg/kg, i.p.) (Glab) inhibits the activation of STING and downstream signaling pathway in vivo. Determination of IFN-β, IL-6 and TNF-α concentrations in collected serum by ELISA kits.

    Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167.  [Abstract]

    Representative images of various tissues stained with hematoxylin–eosin (H&E) staining. Glabridin (20, 40 mg/kg, i.p.) (Glab) Alleviates the Autoinfammatory Response in Trex1−/− Mice.

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    Description

    Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].

    IC50 & Target[1]

    PPARγ

    6.1 μM (EC50)

    Cellular Effect
    Cell Line Type Value Description References
    SW480 IC50
    21.4 μM
    Compound: 66
    Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay
    Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay
    		[PMID: 26841168]
    In Vitro

    Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM[1].
    Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h[2].
    Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines[2].
    Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, 8, and 9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Glabridin Related Antibodies
    In Vivo

    Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    324.37

    Formula

    C20H20O4
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    OC1=CC=C([C@H]2CC3=CC=C4C(C=CC(C)(C)O4)=C3OC2)C(O)=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (77.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0829 mL 15.4145 mL 30.8290 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.98%

    SDS (393 KB)

    COA (249 KB) HNMR (218 KB) LCMS (119 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
    15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
    20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
    25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
    30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
    40 mM 0.0771 mL 0.3854 mL 0.7707 mL 1.9268 mL
    50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
    60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
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    Glabridin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Glabridin59870-68-7PPARReactive Oxygen Species (ROS)BacterialPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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