2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation Anti-infection
  3. TRP Channel COX Bacterial
  4. α-Spinasterol

α-Spinasterol, isolated from Melandrium firmum, has antibacterial activity. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.

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α-Spinasterol Chemical Structure

α-Spinasterol Chemical Structure

CAS No. : 481-18-5

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Based on 1 publication(s) in Google Scholar

α-Spinasterol Related Antibodies

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Description

α-Spinasterol, isolated from Melandrium firmum, has antibacterial activity[1]. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively[2].

IC50 & Target[2]

COX-1

16.17 μM (IC50)

COX-2

7.76 μM (IC50)

TRPV1

 

Molecular Weight

412.69

Formula

C29H48O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@@H](C(C)C)/C=C/[C@@H](C)[C@H]1CC[C@@]2([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.15%

COA (249 KB) HNMR (136 KB) CNMR (126 KB) RP-HPLC (351 KB)

Handling Instructions (2659 KB)
References
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α-Spinasterol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Spinasterol481-18-5TRP ChannelCOXBacterialTransient receptor potential channelsCyclooxygenaseInhibitorinhibitorinhibit

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