1. Flavonoids
  2. Dehydroglyasperin C

Dehydroglyasperin C 

Cat. No.: HY-N7335
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Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.

For research use only. We do not sell to patients.

Dehydroglyasperin C Chemical Structure

Dehydroglyasperin C Chemical Structure

CAS No. : 199331-35-6

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Description

Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities[1][2][3].

In Vitro

Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF[1].
Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: Human aortic smooth muscle cells (HASMC)
Concentration: 0.1 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle.

Western Blot Analysis[1]

Cell Line: Human aortic smooth muscle cells (HASMC)
Concentration: 0.1 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1.
In Vivo

In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.40

Formula

C₂₁H₂₂O₅

CAS No.
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Dehydroglyasperin C
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