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  4. Ethylenediaminetetraacetic acid sodium hydrate

Ethylenediaminetetraacetic acid sodium hydrate  (Synonyms: EDTA sodium hydrate)

Cat. No.: HY-W105700
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Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.

For research use only. We do not sell to patients.

Ethylenediaminetetraacetic acid sodium hydrate Chemical Structure

Ethylenediaminetetraacetic acid sodium hydrate Chemical Structure

CAS No. : 10378-23-1

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Based on 5 publication(s) in Google Scholar

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Ethylenediaminetetraacetic acid sodium hydrate Related Antibodies

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Description

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

In Vitro

Ethylenediaminetetraacetic acid has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
Ethylenediaminetetraacetic acid (0.005-0.01 M) has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
Ethylenediaminetetraacetic acid (1.2 mM) enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethylenediaminetetraacetic acid sodium hydrate Related Antibodies
In Vivo

Ethylenediaminetetraacetic acid (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
Reduced fibrosis of the liver in surviving rats (20%).
Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
Clinical Trial
Molecular Weight

416.20

Formula

C10H16N2Na4O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)CN(CC(=O)O)CCN(CC(=O)O)CC(=O)O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Ethylenediaminetetraacetic acid sodium hydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethylenediaminetetraacetic acid sodium10378-23-1EDTA sodiumBiochemical Assay ReagentsBacterialSODSuperoxide DismutaseAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293T，TDAG8，cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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