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  3. Demethylzeylasteral

Demethylzeylasteral 

Cat. No.: HY-N0587 Purity: 99.90%
Handling Instructions

Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities. Demethylzeylasteral can significantly alleviates atherosclerosis (AS). Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.

For research use only. We do not sell to patients.

Demethylzeylasteral Chemical Structure

Demethylzeylasteral Chemical Structure

CAS No. : 107316-88-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities[1][2][3][4][5]. Demethylzeylasteral can significantly alleviates atherosclerosis (AS)[5]. Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways[2].

Molecular Weight

480.59

Formula

C₂₉H₃₆O₆

CAS No.

107316-88-1

SMILES

C[[email protected]](C1=CC2=O)(CC[[email protected]]3(C)[[email protected]@]4([H])C[[email protected]@](C(O)=O)(C)CC3)[[email protected]]4(CC[[email protected]]1(C5=C2C(C=O)=C(O)C(O)=C5)C)C

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (520.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0808 mL 10.4039 mL 20.8078 mL
5 mM 0.4162 mL 2.0808 mL 4.1616 mL
10 mM 0.2081 mL 1.0404 mL 2.0808 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DemethylzeylasteralApoptosisInhibitorinhibitorinhibit

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Product Name:
Demethylzeylasteral
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HY-N0587
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