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Cat. No.: HY-163183

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JAK3/BTK-IN-7

JAK3/BTK-IN-7 (XL-12) is a JAK3/BTK inhibitor with IC₅₀ values of 2 nM and 14 nM, respectively. JAK3/BTK-IN-7 has anti-inflammatory activity and can be used in the study of rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 2844387-16-0
Formula: C₂₉H₃₀N₈O₄
Molecular Weight:554.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

JAK3/BTK-IN-7 Chemical Structure

CAS No.: 2844387-16-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 2 nM (JAK3)^[1].
IC50: 14 nM (BTK)^[1].

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	366.4 nM Compound: XL-12	Antiproliferative activity against mouse BaF3 cells expressing JAK3 mutant assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay Antiproliferative activity against mouse BaF3 cells expressing JAK3 mutant assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay	[PMID: 37944414]
Daudi	IC₅₀	689.9 nM Compound: XL-12	Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay	[PMID: 37944414]
HUVEC	IC₅₀	27.31 μM Compound: XL-12	Cytotoxicity against HUVEC cells incubated for 48 hrs by MTT assay Cytotoxicity against HUVEC cells incubated for 48 hrs by MTT assay	[PMID: 37944414]
HUVEC	IC₅₀	40.59 μM Compound: XL-12	Cytotoxicity against HUVEC cells incubated for 24 hrs by MTT assay Cytotoxicity against HUVEC cells incubated for 24 hrs by MTT assay	[PMID: 37944414]
HUVEC	IC₅₀	50 μM Compound: XL-12	Cytotoxicity against HUVEC cells incubated for 12 hrs by MTT assay Cytotoxicity against HUVEC cells incubated for 12 hrs by MTT assay	[PMID: 37944414]
L02	IC₅₀	28.19 μM Compound: XL-12	Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay	[PMID: 37944414]
L02	IC₅₀	69.92 μM Compound: XL-12	Cytotoxicity against human L02 cells incubated for 12 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 12 hrs by MTT assay	[PMID: 37944414]
L02	IC₅₀	9.61 μM Compound: XL-12	Cytotoxicity against human L02 cells incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 48 hrs by MTT assay	[PMID: 37944414]
NRK	IC₅₀	11.84 μM Compound: XL-12	Cytotoxicity against rat NRK cells incubated for 48 hrs by MTT assay Cytotoxicity against rat NRK cells incubated for 48 hrs by MTT assay	[PMID: 37944414]
NRK	IC₅₀	15.74 μM Compound: XL-12	Cytotoxicity against rat NRK cells incubated for 24 hrs by MTT assay Cytotoxicity against rat NRK cells incubated for 24 hrs by MTT assay	[PMID: 37944414]
NRK	IC₅₀	50.99 μM Compound: XL-12	Cytotoxicity against rat NRK cells incubated for 12 hrs by MTT assay Cytotoxicity against rat NRK cells incubated for 12 hrs by MTT assay	[PMID: 37944414]
RAW264.7	IC₅₀	19.74 μM Compound: XL-12	Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay	[PMID: 37944414]
RAW264.7	IC₅₀	50.55 μM Compound: XL-12	Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay	[PMID: 37944414]
RAW264.7	IC₅₀	60.78 μM Compound: XL-12	Cytotoxicity against mouse RAW264.7 cells incubated for 12 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells incubated for 12 hrs by MTT assay	[PMID: 37944414]

Chemical Information

CAS No. 2844387-16-0
Molecular Weight 554.60
Formula C₂₉H₃₀N₈O₄
SMILES

NC1=C2C(C3=C4C(OCO4)=C(C=C3)NC(C5=CC=C(C=C5)N(C)C)=O)=NN([C@H]6CN(CCC6)C(C=C)=O)C2=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liang T,et al. Discovery of Novel Dual Bruton’s Tyrosine Kinase (BTK) and Janus Kinase 3 (JAK3) Inhibitors as A Promising Strategy for Rheumatoid Arthritis[J]. Bioorganic & Medicinal Chemistry, 2023: 117354. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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JAK3/BTK-IN-7

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK3/BTK-IN-7 Related Classifications

HY-163183 Related Classifications