1. Immunology/Inflammation
  2. COX
  3. Ketorolac

Ketorolac (Synonyms: RS37619)

Cat. No.: HY-B0580
Handling Instructions

Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.

For research use only. We do not sell to patients.

Ketorolac Chemical Structure

Ketorolac Chemical Structure

CAS No. : 74103-06-3

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Description

Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.

IC50 & Target

COX-1

20 nM (IC50)

COX-2

120 nM (IC50)

In Vitro

Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].

In Vivo

Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits[1]. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats[1]. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[2]. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group[3].

Clinical Trial
Molecular Weight

255.27

Formula

C₁₅H₁₃NO₃

CAS No.

74103-06-3

SMILES

O=C(C1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[2]

Rats[2]
Treated rats receive oral doses of 1 mL aqueous solution of paracetamol (80 mg/kg/rat/day), Ketorolac (4 mg/kg/day) or etoricoxib (10 mg/kg/day) administered by gavage from the day of surgery until death, 2 weeks later. Control rats receive tap water (1 mL/day by gavage). The animals are housed under climate-controlled environment (12 h light/12 h dark, 20-24ºC) with free access to standard laboratory chow and tap water[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

KetorolacRS37619RS 37619RS-37619COXCyclooxygenaseInhibitorinhibitorinhibit

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