Ketorolac hydrochloride
Based on 1 publication(s) in Google Scholar
Ketorolac (RS37619) hydrochloride is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac hydrochloride tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac hydrochloride tromethamine is also a DDX3 inhibitor that can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 218934-99-7
- Formula: C15H14ClNO3
- Molecular Weight:291.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Ketorolac hydrochloride
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 218934-99-7
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Molecular Weight 291.73
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Formula C15H14ClNO3
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SMILES
O=C(C1C2=CC=C(N2CC1)C(C3=CC=CC=C3)=O)O.Cl
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Synonyms
RS37619 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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BMC Anesthesiol
Inflammation and macrophage infiltration exacerbate adult incision response by early life injury. [Abstract]2025 Apr 10;25(1):165. PMID: 40211125
Purity & Documentation
References
[1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [Content Brief]
[2]. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [Content Brief]
[3]. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-9. [Content Brief]
[4]. Samal SK, et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28;5:9982. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ketorolac hydrochloride Related Classifications
HY-B0580D Related Classifications
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