Sunitinib
Based on 96 publication(s) in Google Scholar
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 557795-19-4
- Formula: C22H27FN4O2
- Molecular Weight:398.47
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications Citing Use of MedChemExpress (MCE) Sunitinib
More- Cell Metab. 2021 Oct 5;33(10):2021-2039.e8. [Abstract]
- Adv Mater. 2024 May;36(18):e2310421. [Abstract]
- Nat Biomed Eng. 2018 Aug;2(8):578-588. [Abstract]
- Blood. 2019 Oct 17;134(16):1323-1336. [Abstract]
- Mol Cell. 2025 Dec 18;85(24):4602-4620.e9. [Abstract]
- Mol Cell. 2025 Jul 17;85(14):2733-2748.e7. [Abstract]
- Cell Death Differ. 2026 Mar 23. [Abstract]
- Trends Biotechnol. 2025 Dec 18:S0167-7799(25)00490-1. [Abstract]
- Acta Pharm Sin B. 2025 Oct;15(10):5458-5473. [Abstract]
- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- Autophagy. 2026 May;22(5):982-1002. [Abstract]
- Autophagy. 2025 Mar;21(3):619-638. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(23):e11606. [Abstract]
- Adv Sci (Weinh). 2025 Nov 17:e12563. [Abstract]
- Adv Sci (Weinh). 2025 Sep 15:e06367. [Abstract]
- Theranostics. 2021 Mar 12;11(11):5387-5403. [Abstract]
- Theranostics. 2019 Oct 22;9(26):8377-8391. [Abstract]
- Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]
- Sci Adv. Sci Adv. 2025 Apr 25;11(17):eadu0847. [Abstract]
- Redox Biol. 2026 May:92:104086. [Abstract]
- EBioMedicine. 2018 Nov:37:344-355. [Abstract]
- Cell Rep Med. 2025 Apr 2:102053. [Abstract]
- Cancer Lett. 2024 Jul 1:593:216963. [Abstract]
- Cancer Lett. 2021 Dec 28:523:121-134. [Abstract]
- Cancer Lett. 2019 Apr 10:447:105-114. [Abstract]
- Cell Death Dis. 2024 Jul 27;15(7):533. [Abstract]
- J Pharm Anal. 2023 May;13(5):514-522. [Abstract]
- Acta Pharmacol Sin. 2021 Jan;42(1):108-114. [Abstract]
- EMBO J. 2021 Jun 1;40(11):e106771. [Abstract]
- ACS Appl Mater Interfaces. 2024 Apr 24;16(16):20202-20211. [Abstract]
- Chemosphere. 2022 Dec;308(Pt 2):136354. [Abstract]
- NPJ Precis Oncol. 2026 Jun 19.
- Biomed Pharmacother. 2025 May 14:188:118137. [Abstract]
- Biomed Pharmacother. 2025 May 8:187:118136. [Abstract]
- J Transl Med. 2023 Jan 9;21(1):9. [Abstract]
- Arch Toxicol. 2019 Jun;93(6):1697-1712. [Abstract]
- Clin Transl Med. 2025 Feb;15(2):e70231. [Abstract]
- Br J Cancer. 2024 Jul;131(2):347-360. [Abstract]
- J Med Chem. 2019 Jul 11;62(13):6083-6101. [Abstract]
- J Med Chem. 2016 Sep 22;59(18):8456-72. [Abstract]
- Biochem Pharmacol. 2025 Jun 3:117023. [Abstract]
- Virulence. 2022 Dec;13(1):1849-1867. [Abstract]
- Biomacromolecules. 2021 Jun 14;22(6):2625-2640. [Abstract]
- Commun Biol. 2026 Feb 3;9(1):355. [Abstract]
- Stem Cell Reports. 2017 Dec 12;9(6):1948-1960. [Abstract]
- Front Pharmacol. 2021 Mar 8;12:644342. [Abstract]
- Front Pharmacol. 2021 Apr 29:12:664181. [Abstract]
- Eur J Pharm Sci. 2026 Mar 1:218:107440. [Abstract]
- Int Immunopharmacol. 2020 Apr;81:106227. [Abstract]
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Mol Oncol. 2024 Jan;18(1):136-155. [Abstract]
- Cancers (Basel). 2022 Aug 13;14(16):3917. [Abstract]
- J Cell Mol Med. 2025 Feb;29(4):e70428. [Abstract]
- Ther Adv Med Oncol. 2019 May 17:11:1758835919849757. [Abstract]
- iScience. 2024 Jun 28;27(7):110415. [Abstract]
- J Biol Chem. 2026 Jun;302(6):111461. [Abstract]
- Sci Rep. 2026 Feb 6;16(1):7619. [Abstract]
- Sci Rep. 2025 Aug 17;15(1):30048. [Abstract]
- Bioengineering (Basel). 2025 Oct 19;12(10):1121. [Abstract]
- Cell Signal. 2024 Sep 20:111425. [Abstract]
- Heliyon. 2024 Mar 16;10(6):e28295. [Abstract]
- Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. [Abstract]
- Exp Cell Res. 2025 Nov 22;454(2):114839. [Abstract]
- Food Chem Toxicol. 2023 May:175:113743. [Abstract]
- Exp Cell Res. 2020 Aug 1;393(1):112054. [Abstract]
- Eur J Med Res. 2025 Apr 18;30(1):306. [Abstract]
- Hum Cell. 2025 May 13;38(4):100. [Abstract]
- Med Chem Res. 2017, 26(9), 2007-2014.
- R Soc Open Sci. 2025 Apr 23;12(4):241817. [Abstract]
- J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Apr 15:1237:124100. [Abstract]
- Toxicol In Vitro. 2021 Mar;71:105063. [Abstract]
- PLoS One. 2024 Nov 1;19(11):e0308647. [Abstract]
- Acta Oncol. 2025 May 27:64:715-728. [Abstract]
- Biochem Biophys Res Commun. 2025 May 15:771:152027. [Abstract]
- Biochem Biophys Res Commun. 2024 Aug 19:739:150568. [Abstract]
- Biochem Biophys Res Commun. 2024 Feb 26:698:149546. [Abstract]
- Biol Pharm Bull. 2026;49(1):122-129. [Abstract]
- Mol Clin Oncol. 2024 Jan 18;20(3):21. [Abstract]
- Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81. [Abstract]
- bioRxiv. 2026 Apr 21.
- Res Sq. 2026 Apr 16.
- bioRxiv. 2026 Feb 20.
- Patent. US20240325538A1.
- Patent. US20240238271A1.
- bioRxiv. 2024 Aug 8:2024.08.08.607189. [Abstract]
- University of Oklahoma. 2024.
- bioRxiv. 2024 Jul 10:2024.07.09.602803. [Abstract]
- Res Sq. 2024 Jun 25.
- Methods Mol Biol. 2024:2777:191-204. [Abstract]
- Patent. US20230226111A1.
- Research Square Preprint. 2022 May.
- Patent. US20220064117A1.
- Research Square Preprint. 2022 Feb.
- University of Michigan. 2021 Jun.
- Oncotarget. 2017 Nov 15;8(67):111110-111118. [Abstract]
- Oncotarget. 2017 Jul 27;8(56):95116-95134. [Abstract]
-
Cell Proliferation/Viability Assay
-
IF
-
WB
-
WB
-
WB
All VEGFR Isoforms
More
Biological Activity
|
VEGFR2 80 nM (IC50) |
PDGFRβ 2 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3 | IC50 |
0.01 μM
Compound: 12b
|
Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation
Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation
|
[PMID: 12646019] |
| 4T1 | IC50 |
16 nM
Compound: Sunitinib
|
Cytotoxicity against mouse triple negative 4T1 cells
Cytotoxicity against mouse triple negative 4T1 cells
|
[PMID: 24890652] |
| A-375 | IC50 |
5400 nM
Compound: Sunitinib
|
Toxicity against human A375 cells after 72 hrs by cell titer-blue assay
Toxicity against human A375 cells after 72 hrs by cell titer-blue assay
|
[PMID: 19654408] |
| A-375 | IC50 |
11.58 μM
Compound: SU-11248
|
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
|
[PMID: 22483608] |
| A-431 | IC50 |
172.1 μM
Compound: 4
|
Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISA
Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISA
|
[PMID: 20403700] |
| A-431 | IC50 |
12.2 μM
Compound: SU-11248
|
Inhibition of PDGFRbeta expressed in human A431 cells
Inhibition of PDGFRbeta expressed in human A431 cells
|
[PMID: 20558072] |
| A-431 | IC50 |
172.1 μM
Compound: SU-11248
|
Inhibition of EGFR expressed in human A431 cells
Inhibition of EGFR expressed in human A431 cells
|
[PMID: 20558072] |
| A-431 | IC50 |
18.9 μM
Compound: SU-11248
|
Inhibition of VEGFR2 expressed in human A431 cells
Inhibition of VEGFR2 expressed in human A431 cells
|
[PMID: 20558072] |
| A-431 | IC50 |
172.1 μM
Compound: 4
|
Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISA
Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISA
|
[PMID: 22204741] |
| A-431 | IC50 |
172.1 μM
Compound: SU11248
|
Inhibition of EGFR in human A431 cells pretreated for 60 mins measured after 1 hr by ELISA
Inhibition of EGFR in human A431 cells pretreated for 60 mins measured after 1 hr by ELISA
|
[PMID: 22739090] |
| A-431 | IC50 |
172.1 μM
Compound: 4
|
Inhibition of EGF-induced EGFR phosphorylation in human A431 cells overexpressing EGFR pretreated for 60 mins prior to EGF addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
Inhibition of EGF-induced EGFR phosphorylation in human A431 cells overexpressing EGFR pretreated for 60 mins prior to EGF addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
|
[PMID: 23375090] |
| A-431 | IC50 |
172.1 μM
Compound: Sunitinib
|
Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
|
[PMID: 23434139] |
| A-431 | IC50 |
172.1 nM
Compound: Sunitinib
|
Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assay
Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assay
|
[PMID: 24890652] |
| A-431 | IC50 |
172.1 nM
Compound: Sunitinib
|
Inhibition of EGFR in human A431 cells compound pretreated for 60 min before EGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
Inhibition of EGFR in human A431 cells compound pretreated for 60 min before EGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
|
[PMID: 25882519] |
| A498 | IC50 |
4.3 μM
Compound: Sunitinib
|
Cytotoxicity against human A498 cells after 72 hrs by MTT assay
Cytotoxicity against human A498 cells after 72 hrs by MTT assay
|
[PMID: 23489626] |
| A498 | IC50 |
7981 nM
Compound: Sunitinib
|
Antiproliferative activity against human A498 cells after 48 hrs by MTT assay
Antiproliferative activity against human A498 cells after 48 hrs by MTT assay
|
[PMID: 29057042] |
| A498 | IC50 |
1.25 μM
Compound: Sunitinib
|
Cytotoxicity against human A498 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A498 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 32947227] |
| A498 | IC50 |
1.2 μM
Compound: Sunitinib
|
Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
|
[PMID: 36332882] |
| A498 | IC50 |
1.25 μM
Compound: 1
|
Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
|
[PMID: 38278080] |
| A549 | IC50 |
2 μM
Compound: Sunitinib, sutent
|
Inhibition of c-Met dependent HGF-induced human A549 cell migration
Inhibition of c-Met dependent HGF-induced human A549 cell migration
|
[PMID: 18434145] |
| A549 | IC50 |
6.61 μM
Compound: Su11248
|
Antitumor activity against human A549 cells
Antitumor activity against human A549 cells
|
[PMID: 21450463] |
| A549 | IC50 |
18.5 μM
Compound: 3, SU-11248
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| A549 | IC50 |
12.35 μM
Compound: SU-11248
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 22483608] |
| A549 | IC50 |
2.44 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23602441] |
| A549 | IC50 |
7.93 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| A549 | IC50 |
9.1 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
|
[PMID: 26920800] |
| A549 | IC50 |
14.4 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 27397498] |
| A549 | IC50 |
14.4 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| A549 | IC50 |
2.44 μM
Compound: Sunitinib
|
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
|
[PMID: 27575478] |
| A549 | IC50 |
14.4 μM
Compound: S
|
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| A549 | IC50 |
11 μM
Compound: Sunitinib
|
Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
|
[PMID: 30502686] |
| A549 | IC50 |
11 μM
Compound: Sunitinib
|
Antiproliferative activity against human A549 cells incubated for 2 days by MTT assay
Antiproliferative activity against human A549 cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| A549 | IC50 |
22.1 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| A549 | IC50 |
10.14 μM
Compound: Sunitinib
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Blue assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Blue assay
|
[PMID: 32531682] |
| A549 | IC50 |
3.06 μM
Compound: Sunitinib
|
Antiproliferative activity against human Non-small-cell lung cancer A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human Non-small-cell lung cancer A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 32531682] |
| A549 | IC50 |
7.9 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
|
[PMID: 33421712] |
| A549 | IC50 |
5.73 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 36970141] |
| A549 | IC50 |
6.61 μM
Compound: Sunitinib
|
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| A549 | IC50 |
18.58 μM
Compound: Sunitinib
|
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
|
10.1039/C1MD00105A |
| ACHN | IC50 |
2.5 μM
Compound: SUN
|
Cytotoxicity against human ACHN cells assessed as inhibition of cell viability after 6 days by MTT assay
Cytotoxicity against human ACHN cells assessed as inhibition of cell viability after 6 days by MTT assay
|
[PMID: 23360104] |
| ACHN | IC50 |
5.7 μM
Compound: Sunitinib
|
Cytotoxicity against human ACHN cells after 72 hrs by MTT assay
Cytotoxicity against human ACHN cells after 72 hrs by MTT assay
|
[PMID: 23489626] |
| B16-F10 | IC50 |
15.35 μM
Compound: Sunitinib
|
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 36970141] |
| BaF3 | IC50 |
1.2 μM
Compound: SU-11248
|
Growth inhibition of mouse BA/F3 cells assessed as incorporation of [3H]thymidine incorporation after 72 hrs by liquid scintillation counting
Growth inhibition of mouse BA/F3 cells assessed as incorporation of [3H]thymidine incorporation after 72 hrs by liquid scintillation counting
|
[PMID: 20117004] |
| BaF3 | IC50 |
>10 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
0.0023 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Tel-PDGFRbeta assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Tel-PDGFRbeta assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
0.035 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
0.238 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Tel-KDR-myc1.3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Tel-KDR-myc1.3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
0.297 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing PTC3-RET assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing PTC3-RET assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
1.154 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing NPM-ALK assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing NPM-ALK assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
1.289 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Tel-IGF-1R assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Tel-IGF-1R assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
1.469 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing KIT D816V mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing KIT D816V mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
1.561 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Tel-FGFR3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Tel-FGFR3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
3.846 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing ERBB2 V659E mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing ERBB2 V659E mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
5.124 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Trp-MET assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Trp-MET assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | IC50 |
7.177 μM
Compound: Sunitinib
|
Antiproliferative activity against mouse BaF3 cells expressing Bcr-ABL assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
Antiproliferative activity against mouse BaF3 cells expressing Bcr-ABL assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
|
[PMID: 26629594] |
| BaF3 | EC50 |
>1000 nM
Compound: Sunitinib
|
Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
[PMID: 27010810] |
| BaF3 | GI50 |
0.002 μM
Compound: 2
|
Inhibition of Tel-fused cKIT T670I mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT T670I mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.006 μM
Compound: 2
|
Inhibition of Tel-fused cKIT V559D/V654A double mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT V559D/V654A double mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.009 μM
Compound: 2
|
Inhibition of Tel-fused cKIT V559D mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT V559D mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.02 μM
Compound: 2
|
Inhibition of Tel-fused cKIT V654A mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT V654A mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.023 μM
Compound: 2
|
Inhibition of Tel-fused cKIT L567P mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT L567P mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.053 μM
Compound: 2
|
Inhibition of Tel-fused cKIT T670I/V559D double mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT T670I/V559D double mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.078 μM
Compound: 2
|
Inhibition of Tel-fused cKIT (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
0.51 μM
Compound: 2
|
Inhibition of Tel-fused cKIT N822K mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT N822K mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
1.38 μM
Compound: 2
|
Inhibition of Tel-fused cKIT D816V mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
Inhibition of Tel-fused cKIT D816V mutant (unknown origin) transfected in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| BaF3 | GI50 |
2.78 μM
Compound: 2
|
Antiproliferative activity against mouse BAF3 cells
Antiproliferative activity against mouse BAF3 cells
|
[PMID: 27077705] |
| BaF3 | GI50 |
1.6 μM
Compound: 2
|
Cytotoxicity mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay
Cytotoxicity mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay
|
[PMID: 27545040] |
| BaF3 | GI50 |
4.789 μM
Compound: 2
|
Cytotoxicity in mouse parental BA/F3 cells incubated for 72 hrs by MTS assay
Cytotoxicity in mouse parental BA/F3 cells incubated for 72 hrs by MTS assay
|
[PMID: 30204441] |
| BaF3 | GI50 |
1.01 μM
Compound: 2
|
Growth inhibition of mouse BAF3 cells measured after 72 hrs by CCK8 assay
Growth inhibition of mouse BAF3 cells measured after 72 hrs by CCK8 assay
|
[PMID: 31250638] |
| BaF3 | GI50 |
1.3 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
19.38 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835H mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835H mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
2.3 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835V mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835V mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
4.3 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835N mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835N mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
6.5 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835F mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835F mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
6.9 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835Y mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-WT-D835Y mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
67.8 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD-F691L mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD-F691L mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
8.7 nM
Compound: Sunitinib
|
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD-D835Y mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Growth inhibition of mouse BaF3 cells transfected with FLT3-ITD-D835Y mutation assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 35923716] |
| BaF3 | GI50 |
2.7 nM
Compound: 1
|
Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
|
[PMID: 39353237] |
| BaF3 | GI50 |
2256 nM
Compound: 1
|
Growth inhibition of mouse BaF3 incubated for 72 hrs by CCK-8 assay
Growth inhibition of mouse BaF3 incubated for 72 hrs by CCK-8 assay
|
[PMID: 39353237] |
| BEAS-2B | IC50 |
6.09 μM
Compound: Sunitinib
|
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 36970141] |
| Bel-7402 | IC50 |
2.67 μM
Compound: Sunitinib
|
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| Bel-7402 | EC50 |
11 μM
Compound: Sunitinib
|
Photocytotoxicity against human Bel7402 cells assessed as cell viability preincubated for 5 hrs with cells followed by UVA-1 irradiation at 3.0 mW/cm'2 for 20 mins measured after 48 hrs by CCK8 assay
Photocytotoxicity against human Bel7402 cells assessed as cell viability preincubated for 5 hrs with cells followed by UVA-1 irradiation at 3.0 mW/cm'2 for 20 mins measured after 48 hrs by CCK8 assay
|
[PMID: 26584085] |
| BT-474 | EC50 |
0.9 μM
Compound: Sunitinib
|
Antiproliferative activity against human BT474 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT474 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 30996798] |
| BT-549 | IC50 |
15.5 μM
Compound: Sunitinib
|
Cytotoxicity against human BT549 cells after 48 hrs by MTT assay
Cytotoxicity against human BT549 cells after 48 hrs by MTT assay
|
[PMID: 27128173] |
| BT-549 | IC50 |
15.5 μM
Compound: Sunitinib
|
Cytotoxicity against human BT549 cells after 48 hrs by MTT assay
Cytotoxicity against human BT549 cells after 48 hrs by MTT assay
|
[PMID: 27397498] |
| BT-549 | IC50 |
15.54 μM
Compound: Sunitinib
|
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| BT-549 | IC50 |
15.5 μM
Compound: S
|
Cytotoxicity against human BT549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human BT549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| BT-549 | IC50 |
2.2 μM
Compound: Sunitinib(R)
|
Antiproliferative activity against human BT549 cells expressing NRP1 assessed as cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human BT549 cells expressing NRP1 assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 31699610] |
| BT-549 | IC50 |
3.5 μM
Compound: Sunitinib(R)
|
Antiproliferative activity against human BT549 cells expressing NRP1 assessed as cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human BT549 cells expressing NRP1 assessed as cell viability measured after 72 hrs by MTT assay
|
[PMID: 31699610] |
| BXPC-3 | IC50 |
3.63 μM
Compound: 2
|
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
|
[PMID: 23999040] |
| BXPC-3 | EC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
|
[PMID: 27010810] |
| BXPC-3 | EC50 |
2.5 μM
Compound: Sunitinib
|
Antiproliferative activity against human BxPC3 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human BxPC3 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 30996798] |
| CAKI-1 | GI50 |
0.63 μM
Compound: NSC 750690
|
Antiproliferative activity against human CAKI-1 cells after 48 hrs by SRB assay
Antiproliferative activity against human CAKI-1 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| CAKI-1 | IC50 |
4.93 μM
Compound: Sunitinib
|
Cytotoxicity against human CAKI-1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human CAKI-1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 32947227] |
| CAKI-2 | EC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against human Caki2 cells after 72 hrs by MTT assay
Antiproliferative activity against human Caki2 cells after 72 hrs by MTT assay
|
[PMID: 27010810] |
| CHO | IC50 |
33.4 μM
Compound: sunitinib
|
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
|
[PMID: 23812503] |
| CHO | GI50 |
2.03 μM
Compound: 2
|
Antiproliferative activity against CHO cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against CHO cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| COLO 205 | IC50 |
>4 μM
Compound: 1a
|
Antiproliferative activity against human COLO205 cells after 72 hrs by MTT assay
Antiproliferative activity against human COLO205 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| COLO 205 | IC50 |
8 μM
Compound: Sunitinib
|
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay
|
[PMID: 28756024] |
| DU-145 | IC50 |
10 μM
Compound: Sunitinib, sutent
|
Inhibition of c-Met dependent HGF-induced human DU145 cell scattering
Inhibition of c-Met dependent HGF-induced human DU145 cell scattering
|
[PMID: 18434145] |
| DU-145 | IC50 |
16.4 μM
Compound: Sunitinib
|
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 27128173] |
| DU-145 | IC50 |
16.4 μM
Compound: Sunitinib
|
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 27397498] |
| DU-145 | IC50 |
16.38 μM
Compound: Sunitinib
|
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| DU-145 | IC50 |
16.3 μM
Compound: S
|
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| EKVX | GI50 |
7.9 μM
Compound: NSC 750690
|
Antiproliferative activity against human EKVX cells after 48 hrs by SRB assay
Antiproliferative activity against human EKVX cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| GIST430 | GI50 |
98 nM
Compound: 2
|
Cytotoxicity against human GIST430 cells harboring KIT V654A mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
Cytotoxicity against human GIST430 cells harboring KIT V654A mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
|
[PMID: 28991465] |
| GIST430 | GI50 |
47 nM
Compound: Sunitinib
|
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as reduction in cell viability by methylene blue staining based ass
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as reduction in cell viability by methylene blue staining based ass
|
[PMID: 30968693] |
| GIST430 | GI50 |
47 nM
Compound: Sunitinib
|
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as reduction in cell viability by MTS assay
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as reduction in cell viability by MTS assay
|
[PMID: 30968693] |
| GIST430 | GI50 |
2 μM
Compound: 2
|
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as cell growth inhibition after 120 hrs by methylene blue staining
Antiproliferative activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant assessed as cell growth inhibition after 120 hrs by methylene blue staining
|
[PMID: 31721578] |
| GIST48 | GI50 |
2000 nM
Compound: Sunitinib
|
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as reduction in cell viability by methylene blue staining based assay
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as reduction in cell viability by methylene blue staining based assay
|
[PMID: 30968693] |
| GIST48 | GI50 |
2 μM
Compound: Sunitinib
|
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as reduction in cell viability by MTS assay
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as reduction in cell viability by MTS assay
|
[PMID: 30968693] |
| GIST48 | GI50 |
47 nM
Compound: 2
|
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as cell growth inhibition after 120 hrs by methylene blue staining based assay
Antiproliferative activity against human GIST48 cells harboring c-KIT exon 11 homozygous primary missense V560D mutant and exon 17 heterozygous secondary D820A mutant assessed as cell growth inhibition after 120 hrs by methylene blue staining based assay
|
[PMID: 31721578] |
| GIST882 | GI50 |
0.11 μM
Compound: 2
|
Antiproliferative activity against cKIT dependent human GIST882 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against cKIT dependent human GIST882 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| GIST882 | GI50 |
64 nM
Compound: Sunitinib
|
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as reduction in cell viability by methylene blue staining based assay
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as reduction in cell viability by methylene blue staining based assay
|
[PMID: 30968693] |
| GIST882 | GI50 |
64 nM
Compound: Sunitinib
|
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as reduction in cell viability by MTS assay
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as reduction in cell viability by MTS assay
|
[PMID: 30968693] |
| GIST882 | GI50 |
64 nM
Compound: 2
|
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as cell growth inhibition after 144 hrs by methylene blue staining based assay
Antiproliferative activity against human GIST882 cells harboring c-KIT exon 13 homozygous primary K642E mutant assessed as cell growth inhibition after 144 hrs by methylene blue staining based assay
|
[PMID: 31721578] |
| GISTT1 | GI50 |
0.041 μM
Compound: 2
|
Antiproliferative activity against cKIT dependent human GISTT1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against cKIT dependent human GISTT1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| GISTT1 | GI50 |
40 nM
Compound: 2
|
Cytotoxicity against human GISTT1 cells assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
Cytotoxicity against human GISTT1 cells assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
|
[PMID: 28991465] |
| GISTT1 | GI50 |
5880 nM
Compound: 2
|
Cytotoxicity against human GISTT1 cells harboring KIT D816E mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
Cytotoxicity against human GISTT1 cells harboring KIT D816E mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
|
[PMID: 28991465] |
| GISTT1 | GI50 |
90 nM
Compound: 2
|
Cytotoxicity against human GISTT1 cells harboring KIT T670I mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
Cytotoxicity against human GISTT1 cells harboring KIT T670I mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay
|
[PMID: 28991465] |
| GISTT1 | GI50 |
38 nM
Compound: Sunitinib
|
Antiproliferative activity against human GISTT1 cells harboring heterozygous V560-Y578 del mutation assessed as reduction in cell viability by methylene blue staining based assay
Antiproliferative activity against human GISTT1 cells harboring heterozygous V560-Y578 del mutation assessed as reduction in cell viability by methylene blue staining based assay
|
[PMID: 30968693] |
| GISTT1 | GI50 |
38 nM
Compound: Sunitinib
|
Antiproliferative activity against human GISTT1 cells harboring heterozygous V560-Y578 deletion mutant assessed as reduction in cell viability by MTS assay
Antiproliferative activity against human GISTT1 cells harboring heterozygous V560-Y578 deletion mutant assessed as reduction in cell viability by MTS assay
|
[PMID: 30968693] |
| GISTT1 | GI50 |
0.004 μM
Compound: 2
|
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as growth inhibition after 72 hrs by CCK8 assay
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as growth inhibition after 72 hrs by CCK8 assay
|
[PMID: 31250638] |
| GISTT1 | GI50 |
0.011 μM
Compound: 2
|
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as growth inhibition after 72 hrs by CCK8 assay
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as growth inhibition after 72 hrs by CCK8 assay
|
[PMID: 31250638] |
| GISTT1 | GI50 |
38 nM
Compound: 2
|
Antiproliferative activity against human GISTT1 cells harboring heterozygous deletion mutation at C-kit exon 11 assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
Antiproliferative activity against human GISTT1 cells harboring heterozygous deletion mutation at C-kit exon 11 assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
|
[PMID: 31721578] |
| H69AR | IC50 |
5.8 μM
Compound: Sunitinib
|
Antiproliferative activity against multidrug resistant human NCI-H69AR assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against multidrug resistant human NCI-H69AR assessed as inhibition of cell proliferation by MTT assay
|
[PMID: 32531682] |
| H69AR | IC50 |
5.8 μM
Compound: Sunitinib
|
Antiproliferative activity against multi-drug resistant human NCI-H69AR assessed as reduction in cell viability
Antiproliferative activity against multi-drug resistant human NCI-H69AR assessed as reduction in cell viability
|
[PMID: 32531682] |
| HCT-116 | IC50 |
6.1 μM
Compound: 3, SU-11248
|
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| HCT-116 | IC50 |
18.35 μM
Compound: SU-11248
|
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 22483608] |
| HCT-116 | IC50 |
4.71 μM
Compound: Sunitinib
|
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23602441] |
| HCT-116 | IC50 |
4.71 μM
Compound: Sunitinib
|
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
|
[PMID: 27575478] |
| HCT-116 | IC50 |
5.62 μM
Compound: Sunitinib
|
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 27956344] |
| HCT-116 | IC50 |
5.62 μM
Compound: Sunitinib
|
Antiproliferative activity against human HCT116 cells by MTT assay
Antiproliferative activity against human HCT116 cells by MTT assay
|
[PMID: 30059803] |
| HCT-116 | IC50 |
10.69 μM
Compound: Sunitinib
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 36970141] |
| HCT-116 | IC50 |
2.11 μM
Compound: Sunitinib
|
Cytotoxicity against human HCT116 cells
Cytotoxicity against human HCT116 cells
|
10.1039/C1MD00105A |
| HEK293 | IC50 |
6.1 μM
Compound: Sunitinib
|
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
|
[PMID: 28230985] |
| HEK293 | IC50 |
5 μM
Compound: Sunitinib
|
Antiproliferative activity against HEK293 cells by MTT assay
Antiproliferative activity against HEK293 cells by MTT assay
|
[PMID: 30502686] |
| HEK293 | IC50 |
5 μM
Compound: Sunitinib
|
Antiproliferative activity against HEK293 cells incubated for 2 days by MTT assay
Antiproliferative activity against HEK293 cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| HeLa | EC50 |
>10 μM
Compound: Sutent
|
Toxicity in human HeLa cells assessed as cell cycle arrest at G2M phase by flow cytometry based phenotypic drug discovery based assay
Toxicity in human HeLa cells assessed as cell cycle arrest at G2M phase by flow cytometry based phenotypic drug discovery based assay
|
[PMID: 22409666] |
| HeLa | IC50 |
>30 μM
Compound: Sunitinib
|
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| HeLa | IC50 |
10.4 μM
Compound: S
|
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| HeLa | IC50 |
7.8 μM
Compound: Sunitinib
|
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
|
[PMID: 30502686] |
| HeLa | IC50 |
7.8 μM
Compound: Sunitinib
|
Antiproliferative activity against human HeLa cells incubated for 2 days by MTT assay
Antiproliferative activity against human HeLa cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| HeLa | IC50 |
>30 μM
Compound: Sunitinib
|
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
|
[PMID: 33421712] |
| HepG2 | IC50 |
3.81 μM
Compound: 1a
|
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| HepG2 | IC50 |
15.4 μM
Compound: 3, SU-11248
|
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| HepG2 | IC50 |
13.24 μM
Compound: SU-11248
|
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 22483608] |
| HepG2 | IC50 |
5.61 μM
Compound: 2
|
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
|
[PMID: 23999040] |
| HepG2 | IC50 |
13.6 μM
Compound: sunitinib
|
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 25064347] |
| HepG2 | IC50 |
16.06 μM
Compound: Sunitinib
|
Cytotoxicity against human HepG2 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| HepG2 | IC50 |
16.06 μM
Compound: Sunitinib
|
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 28057423] |
| HepG2 | IC50 |
7.78 μM
Compound: Sunitinib
|
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
|
[PMID: 30059803] |
| HK-2 | IC50 |
5.85 μM
Compound: Sunitinib
|
Antiproliferative activity against human HK2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HK2 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| HL-60 | IC50 |
3.53 μM
Compound: Su11248
|
Antitumor activity against human HL60 cells
Antitumor activity against human HL60 cells
|
[PMID: 21450463] |
| HL-60 | IC50 |
15.5 μM
Compound: 3, SU-11248
|
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| HL-60 | IC50 |
36.8 nM
Compound: Sunitinib
|
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
|
[PMID: 25089810] |
| HL-60 | GI50 |
0.001 μM
Compound: 2
|
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| HL-60 | IC50 |
4.95 μM
Compound: Sunitinib
|
Cytotoxicity against human HL60 cells after 72 hrs by CCK-8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK-8 assay
|
[PMID: 27643639] |
| HL-60 | IC50 |
7 μM
Compound: Sunitinib
|
Antiproliferative activity against human HL60 cells by MTT assay
Antiproliferative activity against human HL60 cells by MTT assay
|
[PMID: 30502686] |
| HL-60 | IC50 |
21.5 μM
Compound: Sunitinib
|
Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| HL-60 | IC50 |
8.7 μM
Compound: Sunitinib
|
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
|
[PMID: 36332882] |
| HL-60 | IC50 |
3.53 μM
Compound: Sunitinib
|
Cytotoxicity against Homo sapiens (human) HL60 cells assessed as growth inhibition by MTT assay
Cytotoxicity against Homo sapiens (human) HL60 cells assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| HMEC-1 | IC50 |
7 μM
Compound: Sunitinib
|
Antiangiogenic activity against HMEC1 cells after 20 hrs by tube formation assay
Antiangiogenic activity against HMEC1 cells after 20 hrs by tube formation assay
|
[PMID: 30502686] |
| HMEC-1 | IC50 |
7 μM
Compound: Sunitinib
|
Antiproliferative activity against HMEC1 cells by MTT assay
Antiproliferative activity against HMEC1 cells by MTT assay
|
[PMID: 30502686] |
| HMEC-1 | IC50 |
7 μM
Compound: Sunitinib
|
Antiproliferative activity against HMEC1 cells incubated for 2 days by MTT assay
Antiproliferative activity against HMEC1 cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| HT-29 | IC50 |
1.3 μM
Compound: Sunitinib
|
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 21621880] |
| HT-29 | IC50 |
0.33 μM
Compound: SU11248
|
Antiproliferative activity against human HT-29 cells expressing VEGFR after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells expressing VEGFR after 72 hrs by MTT assay
|
[PMID: 22444679] |
| HT-29 | GI50 |
1.6 μM
Compound: NSC 750690
|
Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay
Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| HT-29 | IC50 |
0.33 μM
Compound: Sunitinib, SU11248
|
Cytotoxicity against VEGFR expressing human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against VEGFR expressing human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 23131541] |
| HT-29 | IC50 |
1.47 μM
Compound: 2
|
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 23999040] |
| HT-29 | IC50 |
4.7 μM
Compound: Sunitinib
|
Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| HT-29 | IC50 |
1.7 μM
Compound: Sunitinib
|
Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
|
[PMID: 26920800] |
| HT-29 | IC50 |
3.8 μM
Compound: Sunitinib
|
Antiproliferative activity against human HT-29 cells by MTT assay
Antiproliferative activity against human HT-29 cells by MTT assay
|
[PMID: 30502686] |
| HT-29 | IC50 |
3.8 μM
Compound: Sunitinib
|
Antiproliferative activity against human HT-29 cells incubated for 2 days by MTT assay
Antiproliferative activity against human HT-29 cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| HT-29 | IC50 |
10.14 μM
Compound: Sunitinib
|
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability celltiter-Glo assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability celltiter-Glo assay
|
[PMID: 32531682] |
| HT-29 | IC50 |
10.34 μM
Compound: Sunitinib
|
Antiproliferative activity against human HT-29 cells assessed as inhibition of VEGF-induced cell proliferation measured after 24 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of VEGF-induced cell proliferation measured after 24 hrs by CCK8 assay
|
[PMID: 33340911] |
| Huh-7 | IC50 |
3.03 μM
Compound: Sunitinib
|
Growth inhibition of human HuH7 cells after 48 hrs by MTT assay
Growth inhibition of human HuH7 cells after 48 hrs by MTT assay
|
[PMID: 27956344] |
| Huh-7 | IC50 |
4707 nM
Compound: Sunitinib
|
Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay
Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay
|
[PMID: 29057042] |
| Huh-7 | IC50 |
3.03 μM
Compound: Sunitinib
|
Antiproliferative activity against human HuH7 cells by MTT assay
Antiproliferative activity against human HuH7 cells by MTT assay
|
[PMID: 30059803] |
| Huh-7 | CC50 |
246 μM
Compound: Sunitinib
|
Cytotoxicity against human HuH7 cells infected with DENV2 New Guinea C by microplate alamar blue assay
Cytotoxicity against human HuH7 cells infected with DENV2 New Guinea C by microplate alamar blue assay
|
[PMID: 31136173] |
| Huh-7 | CC50 |
11.5 μM
Compound: 9
|
Cytotoxicity against human Huh-7 cells
Cytotoxicity against human Huh-7 cells
|
[PMID: 38377825] |
| Huh-7.5 | CC50 |
>10 μM
Compound: 28
|
Cytotoxicity against human Huh7.5 cells
Cytotoxicity against human Huh7.5 cells
|
[PMID: 33539089] |
| Huh-7.5 | CC50 |
>10 μM
Compound: 9
|
Cytotoxicity against human Huh7.5 cells
Cytotoxicity against human Huh7.5 cells
|
[PMID: 38377825] |
| HUVEC | IC50 |
0.03 μM
Compound: Sunitinib, sutent
|
Inhibition of human VEGFR2-dependent ERK phosphorylation in HUVEC
Inhibition of human VEGFR2-dependent ERK phosphorylation in HUVEC
|
[PMID: 18434145] |
| HUVEC | IC50 |
53 nM
Compound: SU-11248
|
Inhibition of KDR autophosphorylation in HUVEC by Western blot analysis
Inhibition of KDR autophosphorylation in HUVEC by Western blot analysis
|
[PMID: 20833039] |
| HUVEC | IC50 |
2.75 μM
Compound: Su11248
|
Inhibition of VEGF-induced cell proliferation in HUVEC by MTT assay
Inhibition of VEGF-induced cell proliferation in HUVEC by MTT assay
|
[PMID: 21450463] |
| HUVEC | IC50 |
4.04 μM
Compound: Su11248
|
Inhibition of bFGF-induced cell proliferation in HUVEC by MTT assay
Inhibition of bFGF-induced cell proliferation in HUVEC by MTT assay
|
[PMID: 21450463] |
| HUVEC | IC50 |
0.12 μM
Compound: Sunitinib
|
Inhibition of VEGF-A induced HUVEC cell sprouting after 24 hrs by angiogenesis assay
Inhibition of VEGF-A induced HUVEC cell sprouting after 24 hrs by angiogenesis assay
|
[PMID: 21741249] |
| HUVEC | EC50 |
645 nM
Compound: SU 011248, Sutent
|
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced tube formation after 24 hrs by phalloidin-sulforhodamine staining method
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced tube formation after 24 hrs by phalloidin-sulforhodamine staining method
|
[PMID: 23583911] |
| HUVEC | IC50 |
11.8 nM
Compound: Sunitinib
|
Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
|
[PMID: 24890652] |
| HUVEC | IC50 |
>3 μM
Compound: Sunitinib
|
Antiproliferative activity against bFGF-stimulated HUVEC cells assessed as cell growth inhibition measured after 24 hrs by BrdUrd incorporation based spectrophotometric analysis
Antiproliferative activity against bFGF-stimulated HUVEC cells assessed as cell growth inhibition measured after 24 hrs by BrdUrd incorporation based spectrophotometric analysis
|
[PMID: 26629594] |
| HUVEC | IC50 |
7 nM
Compound: Sunitinib
|
Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as cell growth inhibition measured after 24 hrs by BrdUrd incorporation based spectrophotometric analysis
Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as cell growth inhibition measured after 24 hrs by BrdUrd incorporation based spectrophotometric analysis
|
[PMID: 26629594] |
| HUVEC | IC50 |
0.8 μM
Compound: Sunitinib
|
Antiangiogenic activity in HUVEC assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiangiogenic activity in HUVEC assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
|
[PMID: 27176944] |
| HUVEC | IC50 |
0.546 μM
Compound: Sunitinib
|
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced capillary tube formation after 8 hrs by matrigel based inverted microscopic analysis
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced capillary tube formation after 8 hrs by matrigel based inverted microscopic analysis
|
[PMID: 29057052] |
| HUVEC | IC50 |
9.92 μM
Compound: Sunitinib
|
Growth inhibition of HUVEC after 24 hrs in presence of VEGF by MTT assay
Growth inhibition of HUVEC after 24 hrs in presence of VEGF by MTT assay
|
[PMID: 29057052] |
| HUVEC | IC50 |
3 μM
Compound: Sunitinib
|
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
|
[PMID: 29482944] |
| HUVEC | IC50 |
6.36 μM
Compound: Sunitinib
|
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
|
[PMID: 29587221] |
| HUVEC | IC50 |
3.2 μM
Compound: Sunitinib
|
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
|
[PMID: 30384047] |
| HUVEC | IC50 |
3.63 μM
Compound: Sunitinib
|
Antiangiogenic activity against VEGF-induced HUVEC assessed as inhibition of cell proliferation preincubated for 30 mins followed by VEGF addition measured after 24 hrs by MTT assay
Antiangiogenic activity against VEGF-induced HUVEC assessed as inhibition of cell proliferation preincubated for 30 mins followed by VEGF addition measured after 24 hrs by MTT assay
|
[PMID: 31295714] |
| HUVEC | IC50 |
6.46 μM
Compound: Sunitinib
|
Antiangiogenic activity against HUVEC assessed as inhibition of cell proliferation measured after 30 mins by MTT assay
Antiangiogenic activity against HUVEC assessed as inhibition of cell proliferation measured after 30 mins by MTT assay
|
[PMID: 31295714] |
| HUVEC | IC50 |
1.5 μM
Compound: Sunitinib
|
Anti-angiogenesis activity in HUVEC assessed as inhibition of VEGF-induced tube formation incubated for 6 hrs by capillary tube formation assay
Anti-angiogenesis activity in HUVEC assessed as inhibition of VEGF-induced tube formation incubated for 6 hrs by capillary tube formation assay
|
[PMID: 32892623] |
| HUVEC | IC50 |
6.37 μM
Compound: Sunitinib
|
Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation in presence of VEGF measured after 24 hrs by CCK8 assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation in presence of VEGF measured after 24 hrs by CCK8 assay
|
[PMID: 33340911] |
| HUVEC | IC50 |
2.54 μM
Compound: Sunitinib
|
Antivascular activity against HUVEC assessed as inhibition of tube formation incubated for 6 hrs by inverted microscopy
Antivascular activity against HUVEC assessed as inhibition of tube formation incubated for 6 hrs by inverted microscopy
|
[PMID: 33902285] |
| HUVEC | IC50 |
2.1 μM
Compound: Sunitinib
|
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced capillary tube formation incubated for 6 hrs by capillary tube formation assay
Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced capillary tube formation incubated for 6 hrs by capillary tube formation assay
|
[PMID: 35294831] |
| HUVEC | IC50 |
12 nM
Compound: Sunitinib
|
Inhibition of VEGF-induced HUVECs proliferation
Inhibition of VEGF-induced HUVECs proliferation
|
[PMID: 37285684] |
| HUVEC | IC50 |
2.75 μM
Compound: Sunitinib
|
Cytotoxicity against VEGF-stimulated HUVECs assessed as growth inhibition by MTT assay
Cytotoxicity against VEGF-stimulated HUVECs assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| HUVEC | IC50 |
3.9 μM
Compound: Sunitinib
|
Cytotoxicity against HUVECs assessed as growth inhibition by MTT assay
Cytotoxicity against HUVECs assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| HUVEC | IC50 |
4.04 μM
Compound: Sunitinib
|
Cytotoxicity against recombinant Homo sapiens (human) basic FGF-stimulated HUVECs assessed as growth inhibition by MTT assay
Cytotoxicity against recombinant Homo sapiens (human) basic FGF-stimulated HUVECs assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| IM-9 | IC50 |
1.35 μM
Compound: Su11248
|
Antitumor activity against human IM9 cells
Antitumor activity against human IM9 cells
|
[PMID: 21450463] |
| IM-9 | IC50 |
1.35 μM
Compound: Sunitinib
|
Cytotoxicity against Homo sapiens (human) IM9 cells assessed as growth inhibition by MTT assay
Cytotoxicity against Homo sapiens (human) IM9 cells assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| Jurkat | IC50 |
>1 μM
Compound: SU
|
Cytotoxicity in human Jurkat cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity in human Jurkat cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
|
[PMID: 30742435] |
| Jurkat | IC50 |
8.5 μM
Compound: Sunitinib
|
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| K562 | IC50 |
2.41 μM
Compound: Su11248
|
Antitumor activity against human K562 cells
Antitumor activity against human K562 cells
|
[PMID: 21450463] |
| K562 | IC50 |
21.9 μM
Compound: 3, SU-11248
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| K562 | GI50 |
1 μM
Compound: 2
|
Antiproliferative activity against BCR-ABL dependent human K562 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against BCR-ABL dependent human K562 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| K562 | IC50 |
14 μM
Compound: Sunitinib
|
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
|
[PMID: 28756024] |
| K562 | EC50 |
12.5 μM
Compound: 6
|
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer glo assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer glo assay
|
[PMID: 32334266] |
| K562 | EC50 |
7.03 μM
Compound: 6
|
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by celltox-green assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by celltox-green assay
|
[PMID: 32334266] |
| K562 | EC50 |
7.23 μM
Compound: 6
|
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
|
[PMID: 32334266] |
| K562 | IC50 |
5.8 μM
Compound: Sunitinib
|
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
|
[PMID: 36332882] |
| K562 | IC50 |
2.41 μM
Compound: Sunitinib
|
Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition by MTT assay
Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| Kasumi 1 | IC50 |
0.016 μM
Compound: 1a
|
Antiproliferative activity against human Kasumi-1 cells after 72 hrs by MTT assay
Antiproliferative activity against human Kasumi-1 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| Kasumi 1 | IC50 |
15 nM
Compound: SU-11248
|
Inhibition of c-Kit autophosphorylation in human Kasumi-1 cells by Western blot analysis
Inhibition of c-Kit autophosphorylation in human Kasumi-1 cells by Western blot analysis
|
[PMID: 20833039] |
| Kasumi 1 | EC50 |
17.3 nM
Compound: Sunitinib
|
Antiproliferative activity against human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by Cell-titer glo luminescent assay
Antiproliferative activity against human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by Cell-titer glo luminescent assay
|
[PMID: 39094274] |
| KB 3-1 | IC50 |
2.3 μM
Compound: sunitinib
|
Cytotoxicity against human P-gp-negative KB-3-1 cells after 72 hrs by MTT assay
Cytotoxicity against human P-gp-negative KB-3-1 cells after 72 hrs by MTT assay
|
[PMID: 19397322] |
| KB-V1 | IC50 |
4.1 μM
Compound: sunitinib
|
Cytotoxicity against human P-glycoprotein-expressing KBV1 cells after 72 hrs by MTT assay
Cytotoxicity against human P-glycoprotein-expressing KBV1 cells after 72 hrs by MTT assay
|
[PMID: 19397322] |
| KU812 cell line | GI50 |
1.1 μM
Compound: 2
|
Antiproliferative activity against BCR-ABL dependent human KU812 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against BCR-ABL dependent human KU812 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| L02 | IC50 |
19.93 μM
Compound: Sunitinib
|
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| L02 | IC50 |
75.6 μM
Compound: sunitinib
|
Antiproliferative activity against human L02 cells after 48 hrs by MTT assay
Antiproliferative activity against human L02 cells after 48 hrs by MTT assay
|
[PMID: 25064347] |
| L02 | IC50 |
4.62 μM
Compound: Sunitinib
|
Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
|
[PMID: 27643639] |
| Leukemia cell | IC50 |
0.03 μM
Compound: 3, SU-11248
|
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing FLT3-ITD mutation assessed as cell viability after 72 hrs by luciferase assay
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing FLT3-ITD mutation assessed as cell viability after 72 hrs by luciferase assay
|
[PMID: 22221201] |
| Leukemia cell | IC50 |
0.03 μM
Compound: 3, SU-11248
|
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing wild type FLT3 assessed as cell viability after 72 hrs by luciferase assay
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing wild type FLT3 assessed as cell viability after 72 hrs by luciferase assay
|
[PMID: 22221201] |
| Leukemia cell | IC50 |
1.1 μM
Compound: 3, SU-11248
|
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing FLT3-D835Y mutation assessed as cell viability after 72 hrs by luciferase assay
Cytotoxicity against human primary leukemia cells isolated from acute myeloid leukemia patient expressing FLT3-D835Y mutation assessed as cell viability after 72 hrs by luciferase assay
|
[PMID: 22221201] |
| LNCaP | IC50 |
12.61 μM
Compound: S
|
Cytotoxicity against human LNCAP cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27210438] |
| MCF7 | GI50 |
2 μM
Compound: NSC 750690
|
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| MCF7 | IC50 |
6.29 μM
Compound: Sunitinib
|
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23602441] |
| MCF7 | IC50 |
27.1 nM
Compound: Sunitinib
|
Cytotoxicity against human ER-positive MCF7 cells
Cytotoxicity against human ER-positive MCF7 cells
|
[PMID: 24890652] |
| MCF7 | IC50 |
29.3 nM
Compound: Sunitinib
|
Cytotoxicity against human taxoid-resistant MCF7 cells
Cytotoxicity against human taxoid-resistant MCF7 cells
|
[PMID: 24890652] |
| MCF7 | IC50 |
10.5 μM
Compound: sunitinib
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 25064347] |
| MCF7 | IC50 |
25.41 μM
Compound: Sunitinib
|
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| MCF7 | IC50 |
23.76 μM
Compound: S
|
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27210438] |
| MCF7 | IC50 |
23.8 μM
Compound: Sunitinib
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| MCF7 | IC50 |
6.29 μM
Compound: Sunitinib
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
|
[PMID: 27575478] |
| MCF7 | IC50 |
25.41 μM
Compound: Sunitinib
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 28057423] |
| MCF7 | IC50 |
0.08 μM
Compound: Sunitinib
|
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
|
[PMID: 30502686] |
| MCF7 | IC50 |
0.08 μM
Compound: Sunitinib
|
Antiproliferative activity against human MCF7 cells incubated for 2 days by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 2 days by MTT assay
|
[PMID: 30878834] |
| MCF7 | EC50 |
0.96 μM
Compound: Sunitinib
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 30996798] |
| MCF7 | IC50 |
6.8 μM
Compound: Sunitinib
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| MCF7 | IC50 |
>100 μM
Compound: Sunitinib
|
Antiproliferative activity against Doxorubicin resistant human MCF7 cells assessed as reduction in cell viability
Antiproliferative activity against Doxorubicin resistant human MCF7 cells assessed as reduction in cell viability
|
[PMID: 32531682] |
| MCF7 | IC50 |
25.4 μM
Compound: Sunitinib
|
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
|
[PMID: 33421712] |
| MDA-MB-231 | IC50 |
4.51 μM
Compound: Su11248
|
Antitumor activity against human MDA-MB-231 cells
Antitumor activity against human MDA-MB-231 cells
|
[PMID: 21450463] |
| MDA-MB-231 | IC50 |
3.7 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 21621880] |
| MDA-MB-231 | IC50 |
22.3 nM
Compound: Sunitinib
|
Cytotoxicity against human triple negative MDA-MB-231 cells
Cytotoxicity against human triple negative MDA-MB-231 cells
|
[PMID: 24890652] |
| MDA-MB-231 | EC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
|
[PMID: 27010810] |
| MDA-MB-231 | IC50 |
7.4 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 27128173] |
| MDA-MB-231 | IC50 |
7.4 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 27397498] |
| MDA-MB-231 | IC50 |
7.44 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| MDA-MB-231 | IC50 |
7.4 μM
Compound: S
|
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| MDA-MB-231 | IC50 |
6 μM
Compound: Sunitinib
|
Anticancer activity against human MDA-MB-231 cells after 48 hrs by XTT assay
Anticancer activity against human MDA-MB-231 cells after 48 hrs by XTT assay
|
[PMID: 28325600] |
| MDA-MB-231 | IC50 |
32 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
|
[PMID: 28756024] |
| MDA-MB-231 | IC50 |
6.98 μM
Compound: Sunitinib
|
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 28760313] |
| MDA-MB-231 | IC50 |
2.6 μM
Compound: Sunitinib(R)
|
Antiproliferative activity against human MDA-MB-231 cells expressing NRP1 assessed as cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells expressing NRP1 assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 31699610] |
| MDA-MB-231 | IC50 |
3.7 μM
Compound: Sunitinib(R)
|
Antiproliferative activity against human MDA-MB-231 cells expressing NRP1 assessed as cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells expressing NRP1 assessed as cell viability measured after 72 hrs by MTT assay
|
[PMID: 31699610] |
| MDA-MB-231 | IC50 |
4.51 μM
Compound: Sunitinib
|
Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as growth inhibition by MTT assay
Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as growth inhibition by MTT assay
|
10.1007/s00044-012-0170-3 |
| MDA-MB-435 | GI50 |
2 μM
Compound: NSC 750690
|
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| MDA-MB-435 | IC50 |
9.7 nM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-435 cells
Cytotoxicity against human MDA-MB-435 cells
|
[PMID: 24890652] |
| MDA-MB-435 | IC50 |
9.3 μM
Compound: Sunitinib
|
Cytotoxicity against human MDA-MB-435 cells by MTT assay
Cytotoxicity against human MDA-MB-435 cells by MTT assay
|
[PMID: 26920800] |
| MDA-MB-468 | IC50 |
6.1 nM
Compound: Sunitinib
|
Cytotoxicity against human triple negative MDA-MB-468 cells
Cytotoxicity against human triple negative MDA-MB-468 cells
|
[PMID: 24890652] |
| MEG-01 | GI50 |
1.2 μM
Compound: 2
|
Antiproliferative activity against human BCR-ABL dependent MEG01 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against human BCR-ABL dependent MEG01 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| MKN-45 | IC50 |
9.25 μM
Compound: Sunitinib
|
Antiproliferative activity against human MKN-45 cells assessed assessed as inhibition of VEGF-induced cell proliferation measured after 24 hrs by CCK8 assay
Antiproliferative activity against human MKN-45 cells assessed assessed as inhibition of VEGF-induced cell proliferation measured after 24 hrs by CCK8 assay
|
[PMID: 33340911] |
| MOLM-13 | IC50 |
17.7 nM
Compound: Sunitinib
|
Cytotoxicity against human MOLM13 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human MOLM13 cells assessed as cell viability after 48 hrs by MTT assay
|
[PMID: 25089810] |
| MOLM-13 | GI50 |
54 nM
Compound: 2
|
Antiproliferative activity against human MOLM13 harboring FLT3-ITD mutant assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
Antiproliferative activity against human MOLM13 harboring FLT3-ITD mutant assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
|
[PMID: 31721578] |
| MOLM-13 | EC50 |
14.3 nM
Compound: 6
|
Cytotoxicity against human MOLM-13 cells assessed as cell viability measured after 72 hrs by MTS assay
Cytotoxicity against human MOLM-13 cells assessed as cell viability measured after 72 hrs by MTS assay
|
[PMID: 32334266] |
| MOLM-13 | IC50 |
69.6 nM
Compound: Sunitinib
|
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by Cell Counting Kit-8 assay
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by Cell Counting Kit-8 assay
|
[PMID: 33797247] |
| MOLM-13 | IC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against Quizartinib-resistant human MOLM-13 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against Quizartinib-resistant human MOLM-13 cells incubated for 48 hrs by CCK8 assay
|
[PMID: 38655686] |
| MOLM-13 | IC50 |
1463.3 nM
Compound: Sunitinib
|
Antiproliferative activity against Sunitinib-resistant human MOLM-13 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against Sunitinib-resistant human MOLM-13 cells incubated for 48 hrs by CCK8 assay
|
[PMID: 38655686] |
| MOLM-14 | GI50 |
0.005 μM
Compound: 2
|
Antiproliferative activity against FLT3-ITD dependent human MOLM14 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against FLT3-ITD dependent human MOLM14 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| MONO-MAC-6 | IC50 |
5.7 μM
Compound: Sunitinib
|
Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| MV4-11 | IC50 |
4.3 nM
Compound: Sunitinib
|
Cytotoxicity against human MV4-11 cells after 72 hrs by cell titer-blue assay
Cytotoxicity against human MV4-11 cells after 72 hrs by cell titer-blue assay
|
[PMID: 19654408] |
| MV4-11 | IC50 |
4.3 nM
Compound: sunitinib
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
|
[PMID: 19754199] |
| MV4-11 | IC50 |
0.009 μM
Compound: 1a
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| MV4-11 | IC50 |
9 nM
Compound: SU-11248
|
Cytotoxicity against human MV4-11 cells by MTT assay
Cytotoxicity against human MV4-11 cells by MTT assay
|
[PMID: 20833039] |
| MV4-11 | IC50 |
0.003 μM
Compound: Sunitinib
|
Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay
Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay
|
[PMID: 22452518] |
| MV4-11 | IC50 |
153 nM
Compound: Chemical Probe: Sunitinib
|
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay
|
[PMID: 22829080] |
| MV4-11 | IC50 |
0.003 μM
Compound: Sunitinib
|
Antiproliferative activity against human MV411 cells after 48 hrs by MTT assay
Antiproliferative activity against human MV411 cells after 48 hrs by MTT assay
|
[PMID: 24904961] |
| MV4-11 | IC50 |
24.3 nM
Compound: Sunitinib
|
Cytotoxicity against human MV4-11 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human MV4-11 cells assessed as cell viability after 48 hrs by MTT assay
|
[PMID: 25089810] |
| MV4-11 | GI50 |
0.001 μM
Compound: 2
|
Antiproliferative activity against FLT3-ITD dependent human MV4-11 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against FLT3-ITD dependent human MV4-11 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| MV4-11 | IC50 |
38.5 nM
Compound: Sunitinib
|
Antiproliferative activity against human MV4-11 cells harboring FLT3 ITD mutant after 72 hrs by MTS assay
Antiproliferative activity against human MV4-11 cells harboring FLT3 ITD mutant after 72 hrs by MTS assay
|
[PMID: 28038328] |
| MV4-11 | IC50 |
<0.01 μM
Compound: Sunitinib
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by Celltiter-Glo luminescent cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by Celltiter-Glo luminescent cell viability assay
|
[PMID: 29935772] |
| MV4-11 | IC50 |
54 nM
Compound: SU
|
Cytotoxicity in human MV4-11 cells assessed as inhibition of cellular viability incubated for 72 hrs by CellTiter-Blue assay
Cytotoxicity in human MV4-11 cells assessed as inhibition of cellular viability incubated for 72 hrs by CellTiter-Blue assay
|
[PMID: 30742435] |
| MV4-11 | IC50 |
8 nM
Compound: Sunitinib
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
|
[PMID: 32659083] |
| MV4-11 | IC50 |
31.5 nM
Compound: Sunitinib
|
Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by Cell Counting Kit-8 assay
Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by Cell Counting Kit-8 assay
|
[PMID: 33797247] |
| NCI-H1299 | EC50 |
1.54 μM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 30996798] |
| NCI-H1975 | EC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by MTT assay
|
[PMID: 27010810] |
| NCI-H3122 | IC50 |
0.83 μM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H3122 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H3122 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| NCI-H460 | IC50 |
>4 μM
Compound: 1a
|
Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| NCI-H460 | IC50 |
2.7 μM
Compound: Sunitinib
|
Cytotoxicity against human H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 21621880] |
| NCI-H460 | IC50 |
4.31 μM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| NCI-H526 | IC50 |
1.01 μM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H526 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H526 cells after 72 hrs by MTT assay
|
[PMID: 24904961] |
| NCI-H727 | IC50 |
10120 nM
Compound: Sunitinib
|
Antiproliferative activity against human NCI-H727 cells after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H727 cells after 48 hrs by MTT assay
|
[PMID: 29057042] |
| NIH3T3 | IC50 |
<0.007 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 0.1% bovine serum albumin
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 0.1% bovine serum albumin
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
<0.007 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 0.5% bovine serum albumin
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 0.5% bovine serum albumin
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
<0.007 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells without bovine serum albumin
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells without bovine serum albumin
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
0.008 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
0.008 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 1% bovine serum albumin
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 1% bovine serum albumin
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
0.05 μM
Compound: 12b
|
Inhibition of Vascular endothelial growth factor receptor in 3T3 cells
Inhibition of Vascular endothelial growth factor receptor in 3T3 cells
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
0.083 μM
Compound: 12b
|
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 5% bovine serum albumin
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells with 5% bovine serum albumin
|
[PMID: 12646019] |
| NIH3T3 | IC50 |
18 nM
Compound: SU-11248
|
Inhibitory concentration against human KDR kinase expressed in NIH3T3 cells with 4 uM Biotin-Ahx-AEEEYFFLFA-amide at ambient temperature for 1 hr
Inhibitory concentration against human KDR kinase expressed in NIH3T3 cells with 4 uM Biotin-Ahx-AEEEYFFLFA-amide at ambient temperature for 1 hr
|
[PMID: 16162008] |
| OCI-AML-5 | IC50 |
14 nM
Compound: Sunitinib
|
Antiproliferative activity against human OCI-AML5 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
Antiproliferative activity against human OCI-AML5 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
|
[PMID: 32659083] |
| OVCAR-3 | GI50 |
3.2 μM
Compound: NSC 750690
|
Antiproliferative activity against human OVCAR3 cells after 48 hrs by SRB assay
Antiproliferative activity against human OVCAR3 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| PA-1 | IC50 |
7.97 μM
Compound: S
|
Cytotoxicity against human PA1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human PA1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27210438] |
| PANC-1 | IC50 |
14.94 μM
Compound: Sunitinib
|
Cytotoxicity against human PANC1 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human PANC1 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| PANC-1 | EC50 |
13 μM
Compound: Sunitinib
|
Photocytotoxicity against human PANC1 cells assessed as cell viability preincubated for 5 hrs with cells followed by UVA-1 irradiation at 3.0 mW/cm'2 for 20 mins measured after 48 hrs by CCK8 assay
Photocytotoxicity against human PANC1 cells assessed as cell viability preincubated for 5 hrs with cells followed by UVA-1 irradiation at 3.0 mW/cm'2 for 20 mins measured after 48 hrs by CCK8 assay
|
[PMID: 26584085] |
| PBMC | IC50 |
46.3 μM
Compound: Sunitinib
|
Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| PC-3 | IC50 |
25.1 μM
Compound: 3, SU-11248
|
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
|
[PMID: 22019188] |
| PC-3 | IC50 |
55.6 μM
Compound: Sunitinib
|
Cytotoxicity against human PC3 cells by MTT assay
Cytotoxicity against human PC3 cells by MTT assay
|
[PMID: 26920800] |
| PC-3 | EC50 |
>1000 nM
Compound: Sunitinib
|
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
|
[PMID: 27010810] |
| PC-3 | IC50 |
19.6 μM
Compound: Sunitinib
|
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
|
[PMID: 27128173] |
| PC-3 | IC50 |
19.6 μM
Compound: Sunitinib
|
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27448916] |
| PC-3 | IC50 |
12.6 μM
Compound: S
|
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| PC-9 | IC50 |
10.97 μM
Compound: SU-11248
|
Cytotoxicity against human PC9 cells after 48 hrs by MTT assay
Cytotoxicity against human PC9 cells after 48 hrs by MTT assay
|
[PMID: 22483608] |
| RCC4 | IC50 |
4 μM
Compound: Sunitinib
|
Anticancer activity against human RCC4 cells after 48 hrs by XTT assay
Anticancer activity against human RCC4 cells after 48 hrs by XTT assay
|
[PMID: 28325600] |
| Rec1 | GI50 |
0.87 μM
Compound: 2
|
Antiproliferative activity against human Rec1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against human Rec1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| RS4-11 | IC50 |
34 nM
Compound: Sunitinib
|
Inhibition of FLT3 ITD mutant autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay
Inhibition of FLT3 ITD mutant autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay
|
[PMID: 19654408] |
| RS4-11 | IC50 |
9.9 nM
Compound: Sunitinib
|
Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay
Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay
|
[PMID: 19654408] |
| RS4-11 | IC50 |
1 μM
Compound: 1a
|
Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay
Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| RS4-11 | IC50 |
16 nM
Compound: SU-11248
|
Inhibition of FLT3 autophosphorylation in human RS4-11 cells by Western blot analysis
Inhibition of FLT3 autophosphorylation in human RS4-11 cells by Western blot analysis
|
[PMID: 20833039] |
| RWPE-1 | IC50 |
23 μM
Compound: Sunitinib
|
Cytotoxicity against human RWPE1 cells after 48 hrs by MTT assay
Cytotoxicity against human RWPE1 cells after 48 hrs by MTT assay
|
[PMID: 27128173] |
| RWPE-1 | IC50 |
23 μM
Compound: S
|
Cytotoxicity against human RWPE1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human RWPE1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27210438] |
| RWPE-1 | IC50 |
25.2 μM
Compound: S
|
Cytotoxicity against human RWPE1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human RWPE1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 27639369] |
| SF-539 | IC50 |
12.2 μM
Compound: 4
|
Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA
Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA
|
[PMID: 20403700] |
| SF-539 | IC50 |
12.2 μM
Compound: 4
|
Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA
Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA
|
[PMID: 22204741] |
| SF-539 | IC50 |
83.1 μM
Compound: SU11248
|
Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA
Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA
|
[PMID: 22739090] |
| SF-539 | IC50 |
83.1 μM
Compound: 4
|
Inhibition of PDGF-BB-induced PDGFR beta phosphorylation in human SF539 cells overexpressing PDGFR beta pretreated for 60 mins prior to PDGF-BB addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
Inhibition of PDGF-BB-induced PDGFR beta phosphorylation in human SF539 cells overexpressing PDGFR beta pretreated for 60 mins prior to PDGF-BB addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
|
[PMID: 23375090] |
| SF-539 | IC50 |
83.1 μM
Compound: Sunitinib
|
Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA
|
[PMID: 23434139] |
| Sf9 | IC50 |
>5 μM
Compound: 1
|
Inhibition of GST-tagged c-Met expressed in Sf9 cells
Inhibition of GST-tagged c-Met expressed in Sf9 cells
|
[PMID: 19854051] |
| Sf9 | IC50 |
185 nM
Compound: 1
|
Inhibition of GST-tagged VEGFR expressed in Sf9 cells
Inhibition of GST-tagged VEGFR expressed in Sf9 cells
|
[PMID: 19854051] |
| Sf9 | IC50 |
1.3 μM
Compound: SU-11248
|
Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells
Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells
|
[PMID: 20117004] |
| Sf9 | IC50 |
3021 nM
Compound: Sunitinib
|
Inhibition of ATP-activated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation incubated for 3
Inhibition of ATP-activated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation incubated for 3
|
[PMID: 30968693] |
| Sf9 | IC50 |
48 nM
Compound: Sunitinib
|
Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation measured after 150 mins in pr
Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation measured after 150 mins in pr
|
[PMID: 30968693] |
| Sf9 | IC50 |
80 nM
Compound: Sunitinib
|
Inhibition of unactivated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation incubated for 30
Inhibition of unactivated recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected Sf9 insect cells assessed as decrease in poly (Glu,Tyr) 4:1 phosphorylation incubated for 30
|
[PMID: 30968693] |
| Sf9 | IC50 |
31 nM
Compound: 2
|
Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Her2 peptide as substrate measured after 4 hrs in presence of ATP by Kinase-Glo Plus reagent-based lumine
Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Her2 peptide as substrate measured after 4 hrs in presence of ATP by Kinase-Glo Plus reagent-based lumine
|
[PMID: 31721578] |
| Sf9 | IC50 |
48 nM
Compound: 2
|
Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr) 4:1 as substrate measured after 150 mins in presence of
Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr) 4:1 as substrate measured after 150 mins in presence of
|
[PMID: 31721578] |
| SGC-7901 | IC50 |
18.6 μM
Compound: Sunitinib
|
Cytotoxicity against human SGC7901 cells
Cytotoxicity against human SGC7901 cells
|
10.1039/C1MD00105A |
| SH-SY5Y | IC50 |
83.1 nM
Compound: Sunitinib
|
Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assay
Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assay
|
[PMID: 24890652] |
| SK-MEL-28 | IC50 |
4.13 μM
Compound: Sunitinib
|
Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 36970141] |
| SK-OV-3 | IC50 |
9.21 μM
Compound: Sunitinib
|
Cytotoxicity against human SKOV3 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as inhibition of cell viability after 48 hrs by SRB assay
|
[PMID: 26009164] |
| SK-OV-3 | EC50 |
1.36 μM
Compound: Sunitinib
|
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 30996798] |
| SMMC-7721 | IC50 |
6.47 μM
Compound: Sunitinib
|
Cytotoxicity against human SMMC7721 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 21621880] |
| SNB-19 | GI50 |
10 μM
Compound: NSC 750690
|
Antiproliferative activity against human SNB19 cells after 48 hrs by SRB assay
Antiproliferative activity against human SNB19 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| SW-620 | GI50 |
1.3 μM
Compound: NSC 750690
|
Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay
Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| SW-620 | IC50 |
6.25 μM
Compound: Sunitinib
|
Growth inhibition of human SW620 cells after 48 hrs by MTT assay
Growth inhibition of human SW620 cells after 48 hrs by MTT assay
|
[PMID: 27956344] |
| SW-620 | IC50 |
6.25 μM
Compound: Sunitinib
|
Antiproliferative activity against human SW620 cells by MTT assay
Antiproliferative activity against human SW620 cells by MTT assay
|
[PMID: 30059803] |
| SW982 | IC50 |
41.2 μM
Compound: Sunitinib
|
Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| T-24 | IC50 |
2.44 μM
Compound: 2
|
Antiproliferative activity against human T24 cells after 72 hrs by MTT assay
Antiproliferative activity against human T24 cells after 72 hrs by MTT assay
|
[PMID: 23999040] |
| THP-1 | IC50 |
0.5 μM
Compound: 1a
|
Antiproliferative activity against human THP1 cells after 72 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| THP-1 | IC50 |
45.7 nM
Compound: Sunitinib
|
Cytotoxicity against human THP1 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human THP1 cells assessed as cell viability after 48 hrs by MTT assay
|
[PMID: 25089810] |
| THP-1 | IC50 |
>1 μM
Compound: SU
|
Cytotoxicity in human THP1 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity in human THP1 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
|
[PMID: 30742435] |
| THP-1 | IC50 |
14.9 μM
Compound: Sunitinib
|
Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| TK-10 | GI50 |
6.3 μM
Compound: NSC 750690
|
Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay
Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| TT | IC50 |
0.04 μM
Compound: Sunitinib
|
Antiproliferative activity against human TT cells pretreated for 72 hrs followed by compound-washout measured after 72 hrs by MTT assay
Antiproliferative activity against human TT cells pretreated for 72 hrs followed by compound-washout measured after 72 hrs by MTT assay
|
[PMID: 24904961] |
| U-251 | IC50 |
18.9 μM
Compound: 4
|
Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISA
Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISA
|
[PMID: 20403700] |
| U-251 | IC50 |
18.9 μM
Compound: 4
|
Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISA
Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISA
|
[PMID: 22204741] |
| U-251 | IC50 |
18.9 μM
Compound: SU11248
|
Inhibition of VEGFR2 in human U251 cells pretreated for 60 mins measured after 1 hr by ELISA
Inhibition of VEGFR2 in human U251 cells pretreated for 60 mins measured after 1 hr by ELISA
|
[PMID: 22739090] |
| U-251 | IC50 |
18.9 μM
Compound: 4
|
Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells overexpressing Flk-1 pretreated for 60 mins prior to VEGF addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells overexpressing Flk-1 pretreated for 60 mins prior to VEGF addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis
|
[PMID: 23375090] |
| U-251 | IC50 |
18.9 μM
Compound: Sunitinib
|
Inhibition of VEGFR2 in human U251 cells assessed as inhibition of VEGF-induced tyrosine phosphorylation incubated for 60 mins prior to VEGF-activation measured 10 mins by ELISA
Inhibition of VEGFR2 in human U251 cells assessed as inhibition of VEGF-induced tyrosine phosphorylation incubated for 60 mins prior to VEGF-activation measured 10 mins by ELISA
|
[PMID: 23434139] |
| U-251 | IC50 |
18.9 nM
Compound: Sunitinib
|
Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assay
Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assay
|
[PMID: 24890652] |
| U-251 | IC50 |
18.9 nM
Compound: sunitinib
|
Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA
Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA
|
[PMID: 24900865] |
| U-251 | IC50 |
18.9 nM
Compound: Sunitinib
|
Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
|
[PMID: 25882519] |
| U-251 | IC50 |
83.1 nM
Compound: Sunitinib
|
Inhibition of PDGFR-beta in human U251 cells compound pretreated for 60 min before PDGF-BB stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
Inhibition of PDGFR-beta in human U251 cells compound pretreated for 60 min before PDGF-BB stimulation for 10 mins by phosphotyrosine ELISA cytoblot method
|
[PMID: 25882519] |
| U-87MG ATCC | IC50 |
59.75 μM
Compound: S
|
Cytotoxicity against human U87MG cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27210438] |
| U-937 | IC50 |
>5 μM
Compound: 1a
|
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
|
[PMID: 20570526] |
| U-937 | GI50 |
1.7 μM
Compound: 2
|
Antiproliferative activity against human U937 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
Antiproliferative activity against human U937 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo/CCK8 assay
|
[PMID: 27077705] |
| U-937 | IC50 |
13.7 μM
Compound: Sunitinib
|
Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 31563013] |
| UACC-257 | GI50 |
4 μM
Compound: NSC 750690
|
Antiproliferative activity against human UACC257 cells after 48 hrs by SRB assay
Antiproliferative activity against human UACC257 cells after 48 hrs by SRB assay
|
[PMID: 22560627] |
| Vero | CC50 |
11.9 μM
Compound: 28
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 33539089] |
| WI-38 | IC50 |
8.56 μM
Compound: Sunitinib
|
Cytotoxicity against human WI38 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human WI38 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 21621880] |
| ZR-75-1 | IC50 |
18.9 μM
Compound: Sunitinib
|
Antiproliferative activity against multi-drug resistant human ZR-75-1 cells assessed as reduction in cell viability
Antiproliferative activity against multi-drug resistant human ZR-75-1 cells assessed as reduction in cell viability
|
[PMID: 32531682] |
| ZR-75-1 | IC50 |
5.87 μM
Compound: Sunitinib
|
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell viability celltiter-Glo assay
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell viability celltiter-Glo assay
|
[PMID: 32531682] |
Sunitinib Malate is also a good inhibitor of KIT and FLT-3[1]. In RS4;11 cells (FLT3-WT), treatment with Sunitinib (SU11248) inhibits FLT3-WT phosphorylation in a dose-dependent manner with IC50 of approximately 250 nM. In MV4;11 cells that express FLT3-ITD, Sunitinib inhibits FLT3-ITD phosphorylation in a dose-dependent manner with an IC50 of 50 nM following a 2-hour treatment[3].In biochemical assays, Sunitinib (SU11248) exhibits competitive inhibition (with regard to ATP) against Flk-1 and PDGFRβ with Ki values of 9 nM and 8 nM, respectively. Sunitinib is also a competitive, albeit less potent, inhibitor of FGFR1 tyrosine kinase activity, with a Ki value of 0.83 μM. In addition to these three structurally related split kinase domain RTKs, the activity of Sunitinib has also been evaluated against a broad panel of additional tyrosine and serine/threonine kinases. In these biochemical assays, the IC50 values for Sunitinib are generally at least 10-fold higher than those for Flk-1 and PDGFR (e.g., IC50values of: >10 μM for EGFR and Cdk2; 4 μM for Met; 2.4 μM for IGFR-1; 0.8 μM for Abl; and 0.6 μM for Src)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 557795-19-4
-
Appearance Solid
-
Molecular Weight 398.47
-
Formula C22H27FN4O2
-
Color Yellow to orange
-
SMILES
O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C
-
Synonyms
SU 11248
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (96)
-
Journal Impact Factor
-
Most Recent
-
Cell Metab
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy. [Abstract]2021 Oct 5;33(10):2021-2039.e8. PMID: 34508696 -
Adv Mater
Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction. [Abstract]2024 May;36(18):e2310421. PMID: 38270289 -
Nat Biomed Eng
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. [Abstract]2018 Aug;2(8):578-588. PMID: 31015631 -
Blood
Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia. [Abstract]2019 Oct 17;134(16):1323-1336. PMID: 31492675 -
Mol Cell
Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression. [Abstract]2025 Dec 18;85(24):4602-4620.e9. PMID: 41418756 -
Mol Cell
YTHDC1 lactylation regulates its phase separation to enhance target mRNA stability and promote RCC progression. [Abstract]2025 Jul 17;85(14):2733-2748.e7. PMID: 40680722 -
Cell Death Differ
2026 Mar 23. PMID: 41872532 -
Trends Biotechnol
Industrialization of 3D hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screening. [Abstract]2025 Dec 18:S0167-7799(25)00490-1. PMID: 41419348 -
Acta Pharm Sin B
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells. [Abstract]2025 Oct;15(10):5458-5473. PMID: 41132849 -
Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
Autophagy
PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via the LRPPRC-PRKN/parkin interaction and cardiolipin biosynthesis. [Abstract]2026 May;22(5):982-1002. PMID: 41612594 -
Autophagy
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α. [Abstract]2025 Mar;21(3):619-638. PMID: 39477683 -
Adv Sci (Weinh)
PDZK1-ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma. [Abstract]2026 Apr;13(23):e11606. PMID: 41698049 -
Adv Sci (Weinh)
Folic Acid-Modified Ginger-Derived Exosome-Like Nanoparticles Co-Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K-Akt Pathway Inhibition, P-gp Downregulation, and Macrophage Reprogramming. [Abstract]2025 Nov 17:e12563. PMID: 41243691 -
Adv Sci (Weinh)
TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression. [Abstract]2025 Sep 15:e06367. PMID: 40948085 -
Theranostics
2021 Mar 12;11(11):5387-5403. PMID: 33859753 -
Theranostics
Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma. [Abstract]2019 Oct 22;9(26):8377-8391. PMID: 31754403 -
Theranostics
Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway. [Abstract]2018 Jul 30;8(15):4262-4278. PMID: 30128052
Sunitinib purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]
BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.
-
Sci Adv
Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer. [Abstract]Sci Adv. 2025 Apr 25;11(17):eadu0847. PMID: 40267193 -
Redox Biol
USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers. [Abstract]2026 May:92:104086. PMID: 41844497 -
EBioMedicine
Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. [Abstract]2018 Nov:37:344-355. PMID: 30348622
Sunitinib purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355. [Abstract]
Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Western blot analysis of UCP1 protein expression level in mouse brown adipose.
Sunitinib purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355. [Abstract]
Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Representative images of immunohistochemistry stainining of UCP1 in BAT.
-
Cell Rep Med
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]2025 Apr 2:102053. PMID: 40187357 -
Cancer Lett
Preoperative neoadjuvant targeted therapy remodels intra-tumoral heterogeneity of clear-cell renal cell carcinoma and ferroptosis inhibition induces resistance progression. [Abstract]2024 Jul 1:593:216963. PMID: 38768682 -
Cancer Lett
Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis. [Abstract]2021 Dec 28:523:121-134. PMID: 34626691 -
Cancer Lett
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models. [Abstract]2019 Apr 10:447:105-114. PMID: 30684595 -
Cell Death Dis
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway. [Abstract]2024 Jul 27;15(7):533. PMID: 39068164 -
J Pharm Anal
A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance. [Abstract]2023 May;13(5):514-522. PMID: 37305785
Sunitinib purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]
Sunitinib (0-100 μM; 72 h) induces significant cell death in T98G cells.
Sunitinib purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]
Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.
Sunitinib purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]
Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.
-
Acta Pharmacol Sin
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]2021 Jan;42(1):108-114. PMID: 32398685 -
EMBO J
Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2 S production. [Abstract]2021 Jun 1;40(11):e106771. PMID: 33909912 -
ACS Appl Mater Interfaces
Tumor Supplying Artery Injection of Liposome@Sunitinib Could Effectively Inhibit the Progression of Kidney Tumor. [Abstract]2024 Apr 24;16(16):20202-20211. PMID: 38624141 -
Chemosphere
The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae. [Abstract]2022 Dec;308(Pt 2):136354. PMID: 36087734 -
-
Biomed Pharmacother
Unravelling the cardioprotective effects of calcitriol in Sunitinib-induced toxicity: A comprehensive in silico and in vitro study. [Abstract]2025 May 14:188:118137. PMID: 40373630 -
Biomed Pharmacother
Inhibition of the PI3K/AKT signaling pathway contributes to the anti-renal cell carcinoma effects of deoxyelephantopin. [Abstract]2025 May 8:187:118136. PMID: 40344699 -
J Transl Med
Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies. [Abstract]2023 Jan 9;21(1):9. PMID: 36624452 -
Arch Toxicol
Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo. [Abstract]2019 Jun;93(6):1697-1712. PMID: 31025080 -
Clin Transl Med
SHP2 inhibition and adjuvant therapy synergistically target KIT-mutant GISTs via ERK1/2-regulated GSK3β/cyclin D1 pathway. [Abstract]2025 Feb;15(2):e70231. PMID: 39981588 -
Br J Cancer
PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway. [Abstract]2024 Jul;131(2):347-360. PMID: 38822145 -
J Med Chem
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)- N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors. [Abstract]2019 Jul 11;62(13):6083-6101. PMID: 31250638 -
J Med Chem
Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase. [Abstract]2016 Sep 22;59(18):8456-72. PMID: 27545040
Sunitinib purchased from MedChemExpress. Usage Cited in: J Med Chem. 2016 Sep 22;59(18):8456-72. [Abstract]
Effect of compounds 1 (Imatinib), 2 (Sunitinib), and 35 on cKIT mediated signaling pathways in GIST-T1 and GIST-5R cancer cell lines.
-
Biochem Pharmacol
Protective effects of artesunate on the neurovascular unit by regulating PDGFRβ signaling in experimental cerebral malaria. [Abstract]2025 Jun 3:117023. PMID: 40473225 -
Virulence
Adaptor complex-mediated trafficking of Newcastle disease virus fusion protein is regulated by the YLMY motif of its cytoplasmic tail. [Abstract]2022 Dec;13(1):1849-1867. PMID: 36258290 -
Biomacromolecules
Toolbox of Biodegradable Dendritic (Poly glycerol sulfate)-SS-poly(ester) Micelles for Cancer Treatment: Stability, Drug Release, and Tumor Targeting. [Abstract]2021 Jun 14;22(6):2625-2640. PMID: 34076415 -
Commun Biol
TGFBI promotes liver fibrosis through remodeling the profibrotic microenvironment by a positive feedback regulatory loop. [Abstract]2026 Feb 3;9(1):355. PMID: 41634371 -
Stem Cell Reports
Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells. [Abstract]2017 Dec 12;9(6):1948-1960. PMID: 29198824 -
Front Pharmacol
2021 Mar 8;12:644342. PMID: 33790797 -
Front Pharmacol
Sodium-Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK-mTOR Signaling Pathway-Mediated Autophagy. [Abstract]2021 Apr 29:12:664181. PMID: 33995090 -
Eur J Pharm Sci
Design, synthesis, formulation, and bioevaluation of ZZP-2, a FLT3-ITD inhibitor for the treatment of acute myeloid leukemia. [Abstract]2026 Mar 1:218:107440. PMID: 41520929 -
Int Immunopharmacol
Modulating the tumor immune microenvironment with sunitinib malate supports the rationale for combined treatment with immunotherapy. [Abstract]2020 Apr;81:106227. PMID: 32078941 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Mol Oncol
Ovarian cancer relies on the PDGFRβ-fibronectin axis for tumorsphere formation and metastatic spread. [Abstract]2024 Jan;18(1):136-155. PMID: 38010623 -
Cancers (Basel)
Physiological Cell Culture Media Tune Mitochondrial Bioenergetics and Drug Sensitivity in Cancer Cell Models. [Abstract]2022 Aug 13;14(16):3917. PMID: 36010911 -
J Cell Mol Med
MATN1-AS1 Promotes Tumour Metastasis and Sunitinib Resistance via E2F2 in Clear Cell Renal Cell Carcinoma. [Abstract]2025 Feb;29(4):e70428. PMID: 39999286 -
Ther Adv Med Oncol
Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors. [Abstract]2019 May 17:11:1758835919849757. PMID: 31205508 -
iScience
Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts. [Abstract]2024 Jun 28;27(7):110415. PMID: 39100925 -
J Biol Chem
2026 Jun;302(6):111461. PMID: 41999888 -
Sci Rep
2026 Feb 6;16(1):7619. PMID: 41651965 -
Sci Rep
Dendrobium officinale Kimura & Migo polysaccharide ameliorates skin photoaging by promoting angiogenesis. [Abstract]2025 Aug 17;15(1):30048. PMID: 40820014 -
Bioengineering (Basel)
Precision Oncology for High-Grade Gliomas: A Tumor Organoid Model for Adjuvant Treatment Selection. [Abstract]2025 Oct 19;12(10):1121. PMID: 41155119 -
Cell Signal
TAF1D promotes tumorigenesis and metastasis by activating PI3K/AKT/mTOR signaling in clear cell renal cell carcinoma. [Abstract]2024 Sep 20:111425. PMID: 39307376 -
Heliyon
Integrated genomic and proteomic analyses identify PYGL as a novel experimental therapeutic target for clear cell renal cell carcinoma. [Abstract]2024 Mar 16;10(6):e28295. PMID: 38545181 -
Biotechnol Bioeng
An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. [Abstract]2021 Dec;118(12):4687-4698. PMID: 34478150 -
Exp Cell Res
Fbxo45 promotes cell viability, invasion and sunitinib resistance of clear cell renal cell carcinoma by targeting Erbin. [Abstract]2025 Nov 22;454(2):114839. PMID: 41285235 -
Food Chem Toxicol
Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation. [Abstract]2023 May:175:113743. PMID: 36972840 -
Exp Cell Res
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia. [Abstract]2020 Aug 1;393(1):112054. PMID: 32376287 -
Eur J Med Res
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis. [Abstract]2025 Apr 18;30(1):306. PMID: 40247376 -
Hum Cell
Sunitinib-resistant renal cell carcinoma cell-derived exosomes promote facilitation of tumor progression via secretion of the lncRNA SNHG16. [Abstract]2025 May 13;38(4):100. PMID: 40358820 -
-
R Soc Open Sci
Synergistic anticancer activity of resveratrol-loaded polymeric nanoparticles and sunitinib in colorectal cancer treatment. [Abstract]2025 Apr 23;12(4):241817. PMID: 40271141 -
J Chromatogr B Analyt Technol Biomed Life Sci
Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients. [Abstract]2024 Apr 15:1237:124100. PMID: 38547701 -
Toxicol In Vitro
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. [Abstract]2021 Mar;71:105063. PMID: 33271325 -
PLoS One
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery. [Abstract]2024 Nov 1;19(11):e0308647. PMID: 39485774 -
Acta Oncol
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models. [Abstract]2025 May 27:64:715-728. PMID: 40426308 -
Biochem Biophys Res Commun
Tyrosine kinase inhibitors induce cardiotoxicity by causing Ca2+ overload through the inhibition of phosphoinositide 3-kinase activity. [Abstract]2025 May 15:771:152027. PMID: 40403685 -
Biochem Biophys Res Commun
Swimming training attenuates doxorubicin induced cardiomyopathy by targeting the mir-17-3p/KEAP1/NRF2 axis. [Abstract]2024 Aug 19:739:150568. PMID: 39178797 -
Biochem Biophys Res Commun
2024 Feb 26:698:149546. PMID: 38266314 -
Biol Pharm Bull
Evaluation of Drug-Induced Kidney Injury by Primary Culture of Rat Kidney Tissue Slices Using Oxygen-Permeable Polyolefin Plate with Low Drug Adsorption. [Abstract]2026;49(1):122-129. PMID: 41565252 -
Mol Clin Oncol
Exploring the anticancer potential of hydrogen sulfide and BAY‑876 on clear cell renal cell carcinoma cells: Uncovering novel mutations in VHL and KDR genes among ccRCC patients. [Abstract]2024 Jan 18;20(3):21. PMID: 38332991 -
Int J Clin Exp Pathol
SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway. [Abstract]2015 Apr 1;8(4):3871-81. PMID: 26097571
Sunitinib purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81. [Abstract]
The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by Western blot (with GAPDH as internal control).
Sunitinib purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81. [Abstract]
The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by RT-PCR (with β-actin as internal control).
-
-
-
-
-
-
bioRxiv
The mammalian Ire1 inhibitor, 4μ8C, exhibits broad anti- Aspergillus activity in vitro and in a treatment model of fungal keratitis. [Abstract]2024 Aug 8:2024.08.08.607189. PMID: 39149375 -
-
bioRxiv
Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer. [Abstract]2024 Jul 10:2024.07.09.602803. PMID: 39026842 -
-
Methods Mol Biol
Co-Delivery Polymeric Poly(Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles to Target Cancer Stem-Like Cells. [Abstract]2024:2777:191-204. PMID: 38478345 -
-
-
-
-
-
Oncotarget
Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs). [Abstract]2017 Nov 15;8(67):111110-111118. PMID: 29340041
Sunitinib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 15;8(67):111110-111118. [Abstract]
In cell EC50 determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells.
-
Oncotarget
The addition of abemaciclib to sunitinib induces regression of renal cell carcinoma xenograft tumors. [Abstract]2017 Jul 27;8(56):95116-95134. PMID: 29221116
Sunitinib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134. [Abstract]
Abemaciclib causes increased PARP cleavage in RCC. In 786-O cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.
Sunitinib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134. [Abstract]
Abemaciclib causes increased PARP cleavage in RCC. In Caki-1 cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.
Solvent & Solubility
DMSO : 20.83 mg/mL (52.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.11 mg/mL (2.79 mM); Clear solution
This protocol yields a clear solution of ≥ 1.11 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (11.1 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
RS4;11 and MV4;11 cell lines are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib (1 nM, 5 nM, 10 nM, 25 nM, 75 nM, 100 nM, 250 nM, 500 nM) and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay in triplicate for each condition, as described by the manufacturer. Trypan blue cell viability assays are performed in parallel and yielded similar results[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice[2]
Female nu/nu mice (8-12 weeks old, 25 grams) are used. Briefly, 3-5×106 tumor cells are implanted s.c. into the hind flank region of mice on day 0. Daily treatment of tumor-bearing mice with oral administration of Sunitinib as a carboxymethyl cellulose suspension or as a citrate buffered (pH 3.5) solution is initiated once the tumors reached the indicated average size. Tumor growth is evaluated based on twice-weekly measurement of tumor volume. Typically, studies are terminated when tumors in vehicle-treated animals reach an average size of 1000 mm3 or when the tumors are judged to adversely effect the well being of the animals.
Rats[4]
Adult male Wistar rats (325-349 g) are used. To validate the ability of the time-lapse imaging method to evaluate the anti-angiogenic effects for a given drug treatment, two drug studies are conducted. In the first study, mesenteric windows are harvested from adult male Wistar rats and cultured for 3 days according to the two experimental groups: 1) 10% serum (n=8 tissues from 4 rats), and 2) 10% serum+Sunitinib (5 μM; n=8 tissues from 4 rats).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9. [Content Brief]
[2]. Ali MM, et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 2011 Mar 2;30(5):894-905. [Content Brief]
[3]. O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. [Content Brief]
[4]. Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5096 mL | 12.5480 mL | 25.0960 mL | 62.7400 mL |
| 5 mM | 0.5019 mL | 2.5096 mL | 5.0192 mL | 12.5480 mL | |
| 10 mM | 0.2510 mL | 1.2548 mL | 2.5096 mL | 6.2740 mL | |
| 15 mM | 0.1673 mL | 0.8365 mL | 1.6731 mL | 4.1827 mL | |
| 20 mM | 0.1255 mL | 0.6274 mL | 1.2548 mL | 3.1370 mL | |
| 25 mM | 0.1004 mL | 0.5019 mL | 1.0038 mL | 2.5096 mL | |
| 30 mM | 0.0837 mL | 0.4183 mL | 0.8365 mL | 2.0913 mL | |
| 40 mM | 0.0627 mL | 0.3137 mL | 0.6274 mL | 1.5685 mL | |
| 50 mM | 0.0502 mL | 0.2510 mL | 0.5019 mL | 1.2548 mL |