1. Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
  2. VEGFR
    PDGFR
    IRE1
    Mitophagy
    Autophagy
    Apoptosis
  3. Sunitinib-d4

Sunitinib-d4 

Cat. No.: HY-10255AS1
Handling Instructions

Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

For research use only. We do not sell to patients.

Sunitinib-d4 Chemical Structure

Sunitinib-d4 Chemical Structure

CAS No. : 1126721-79-6

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Description

Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.50

Formula

C₂₂H₂₃D₄FN₄O₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Sunitinib-d4
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