1. Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
  2. VEGFR
    PDGFR
    IRE1
    Mitophagy
    Autophagy
    Apoptosis
  3. Sunitinib D10

Sunitinib D10 (Synonyms: SU 11248 D10)

Cat. No.: HY-10255AS
Handling Instructions

Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

For research use only. We do not sell to patients.

Sunitinib D10 Chemical Structure

Sunitinib D10 Chemical Structure

CAS No. : 1126721-82-1

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Description

Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

IC50 & Target[1]

VEGFR2

80 nM (IC50)

PDGFRβ

2 nM (IC50)

Molecular Weight

408.54

Formula

C₂₂H₁₇D₁₀FN₄O₂

CAS No.

1126721-82-1

SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sunitinib D10SU 11248 D10Sunitinib D 10Sunitinib D-10VEGFRPDGFRIRE1MitophagyAutophagyApoptosisVascular endothelial growth factor receptorPlatelet-derived growth factor receptorInositol requiring enzyme 1Mitochondrial AutophagyDeuteriumlabeledIre1αautophosphorylationRNaseactivationInhibitorinhibitorinhibit

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Sunitinib D10
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