1. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Autophagy Apoptosis
  2. VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis
  3. Sunitinib-d10

Sunitinib-d10  (Synonyms: SU 11248-d10)

Cat. No.: HY-10255AS Purity: 99.89%
COA Handling Instructions

Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

For research use only. We do not sell to patients.

Sunitinib-d<sub>10</sub> Chemical Structure

Sunitinib-d10 Chemical Structure

CAS No. : 1126721-82-1

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1 mg USD 230 In-stock
5 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

IC50 & Target[1]

VEGFR2

80 nM (IC50)

PDGFRβ

2 nM (IC50)

Molecular Weight

408.54

Formula

C22H17D10FN4O2

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sunitinib-d10
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HY-10255AS
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