Stem bromelain 

Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning^[1][2][3][4].

Stem bromelain (10-50 μg/mL; 12 h) causes Apoptosis, increases the expression of CD80, CD86, results in the dose-dependent secretion of IL-12p70, TNF-α, and IL-6 in peritoneal macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stem bromelain (20 mg/kg) significantly reduces lead accumulation in the kidneys and spleen of lead-exposed WISTAR rats, decreasing serum malondialdehyde and triglyceride levels, and alleviating the elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

37189-34-7

Solid

Off-white to light yellow

[Stem bromelain]

3.4.22.32

≥300U/mg soild

One unit is defined as the amount of enzyme that the absorbance of the trichloroacetic acid soluble from hydrolyzed casein per min product at 275 nm is comparable to that of 1 μg of tyrosine

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.  [Content Brief]

  [2]. Báez R, et al. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Med. 2007 Oct;73(13):1377-83.  [Content Brief]

  [3]. Mahajan S, et al. Stem bromelain-induced macrophage apoptosis and activation curtail Mycobacterium tuberculosis persistence. J Infect Dis. 2012 Aug 1;206(3):366-76.  [Content Brief]

  [4]. Al-Otaibi WR, et al. Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats. Acta Biol Hung. 2015 Jun;66(2):149-60.  [Content Brief]