2. Immunology/Inflammation
  3. Interleukin Related
  4. Raleukin

Raleukin  (Synonyms: AMG-719; Anakinra)

Cat. No.: HY-108841 Purity: 99.40%
COA

Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin (AMG-719) is the first biological agent to block the pro-inflammatory effects.

For research use only. We do not sell to patients.

Raleukin Chemical Structure

Raleukin Chemical Structure

CAS No. : 143090-92-0

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Based on 14 publication(s) in Google Scholar

Raleukin Related Antibodies

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Description

Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin (AMG-719) is the first biological agent to block the pro-inflammatory effects[1][2].

IC50 & Target

IL-1

 

In Vivo

Combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice[2].
Raleukin (AMG-719) enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

17257.60

Appearance

Liquid

Formula

C759H1186N208O232S10
CAS No.
SMILES

[Anakinra]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.40%

COA (232 KB)

Handling Instructions (2659 KB)
References
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Raleukin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Raleukin143090-92-0AMG-719 AnakinraAMG719AMG 719Interleukin RelatedILrheumatoidarthritisInhibitorinhibitorinhibit

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