2. Immunology/Inflammation
  3. Interleukin Related
  4. Raleukin

Raleukin  (Synonyms: Kineret; Anakinra)

Cat. No.: HY-108841 Purity: 99.40%
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Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

For research use only. We do not sell to patients.

CAS No. : 143090-92-0

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Raleukin Related Antibodies

Top Publications Citing Use of Products

52 Publications Citing Use of MCE Raleukin

IF
Flow Cytometry
RT-PCR
In Vivo Imaging

    Raleukin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 24;10(1):417.  [Abstract]

    Bioluminescence imaging (BLI) on days 0, 5, and 10 posttreatment in BM-bearing mice. The treatment groups included vehicle, Raleukin (Anakinra) (100 mg/kg, intraperitoneally, daily), SH4-54 (10 mg/kg every 3 days), and anakinra + SH4-54.

    Raleukin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Jul 16.  [Abstract]

    Representative images and quantification of liver lesions in BALB/c mice intrasplenically injected with CT26 following AAV-SPHK1 or Anakinra (Raleukin) (500 µg; intraperitoneal injection on days 4, 7, 10, 13, and 16) treatment.

    Raleukin purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Apr 7.  [Abstract]

    Ifnγ relative expression (n=3) in Th17 cells differentiated from CD4 Nlrp3-/- mice and their littermate (Lit) controls treated with CASPASE-1 inhibitor (ZYVAD), CASPASE-8 inhibitor (ZIETD), inflammasome inhibitor (MCC950), or Anakinra (Anak) (Raleukin) (300 nM).

    Raleukin purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2024 Mar;19(3):387-398.  [Abstract]

    Effect of IL-1 receptor blockage (IL-1RA, Raleukin) (50 mg/kg, daily) on the lineage shifts of haematopoietic progenitor cells due to administration of OMVs: schematic illustration of the experimental schedule and grouping information (c); frequency of LSKs in Lin-cells, ST-HSCs and MPPs in LSKs as determined by flow cytometry.

    Raleukin purchased from MedChemExpress. Usage Cited in: Circulation. 2021 Sep 14;144(11):893-908.  [Abstract]

    Adhesion of DiI-labeled peripheral blood mononuclear cells (PBMCs) stimulated with TNF-α (18 hours), LPS (18 hours), LPS plus OA (18 hours for LPS priming, 4 hours), or LPS plus oxalate (18 hours for LPS priming, 4 hours) to human aortic endothelial cells (HAECs) as determined by fluorescence microscopy (n=3 per group) in the presence of an anti-IL-1α blocking antibody (1 µg/mL) incubated with PBMCs or an anti-IL-1R1 blocking antibody (Raleukin, 500 ng/mL) incubated with HAECs (10 µg/mL) or an isotype control.

    View All Interleukin Related Isoform Specific Products:

    View All Isoforms
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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    • References

    • Customer Review

    Description

    Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction[1][2][3].

    IC50 & Target

    IL-1

     

    In Vivo

    Combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice[2].
    Raleukin (AMG-719) enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    17.3 kDa

    Formula

    C759H1186N208O232S10
    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Raleukin]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 99.40%

    SDS (251 KB)

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Raleukin Related Classifications

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    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Raleukin143090-92-0Kineret AnakinraInterleukin RelatedILrheumatoidarthritisInhibitorinhibitorinhibit

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