2. Immunology/Inflammation
  3. Interleukin Related
  4. Raleukin

Raleukin  (Synonyms: AMG-719; Anakinra)

Cat. No.: HY-108841 Purity: 99.40%
COA

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Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin (AMG-719) is the first biological agent to block the pro-inflammatory effects.

For research use only. We do not sell to patients.

Raleukin Chemical Structure

Raleukin Chemical Structure

CAS No. : 143090-92-0

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10 mg USD 550 In-stock
50 mg USD 1650 In-stock
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Based on 22 publication(s) in Google Scholar

Raleukin Related Antibodies

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Description

Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin (AMG-719) is the first biological agent to block the pro-inflammatory effects[1][2].

IC50 & Target

IL-1

 

In Vivo

Combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice[2].
Raleukin (AMG-719) enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

17257.60

Formula

C759H1186N208O232S10
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anakinra]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.40%

COA (232 KB)

Handling Instructions (2659 KB)
References
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Raleukin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raleukin143090-92-0AMG-719 AnakinraAMG719AMG 719Interleukin RelatedILrheumatoidarthritisInhibitorinhibitorinhibit

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