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Cat. No.: HY-163390

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RIP1 kinase inhibitor 9

RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 7.04 nM.

For research use only. We do not sell to patients.

CAS No.: 3040025-57-5
Formula: C₂₅H₂₁N₃O₃
Molecular Weight:411.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RIP1 kinase inhibitor 9 Chemical Structure

CAS No.: 3040025-57-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All RIP kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	CC₅₀	>100 μM Compound: SY1	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 38484677]
HT-29	EC₅₀	7.04 nM Compound: SY1	Anti-necroptosis activity against human HT-29 cell assessed as inhibition of TSZ-induced necroptosis by chemiluminescence assay Anti-necroptosis activity against human HT-29 cell assessed as inhibition of TSZ-induced necroptosis by chemiluminescence assay	[PMID: 38484677]

In Vitro

RIP1 kinase inhibitor 9 (10 nM, 4 h) effectively prevents the phosphorylation of both RIP1 and RIP3, hinders necrosome formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RIP1 kinase inhibitor 9 (5 mg/kg for p.o; daily for 7 days) suppresses inflammation in epileptic mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3040025-57-5
Molecular Weight 411.45
Formula C₂₅H₂₁N₃O₃
SMILES

CN1C([C@H](COC2=CC=CC=C21)NC(C3=CC4=C(NC=C4C5=CC=CC=C5)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiang R, et al. Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy. Eur J Med Chem. 2024 Mar 9;269:116304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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RIP1 kinase inhibitor 9

All RIP kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RIP1 kinase inhibitor 9 Related Classifications

HY-163390 Related Classifications