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  5. Astragenol

Astragenol is an intermediate used for Astragenol derivative synthesis. Astragenol derivatives are promising anti-inflammatory agents for prostate cancer research.

For research use only. We do not sell to patients.

Astragenol Chemical Structure

Astragenol Chemical Structure

CAS No. : 86541-79-9

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5 mg USD 50 In-stock
10 mg USD 80 In-stock
25 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Astragenol Related Antibodies

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Description

Astragenol is an intermediate used for Astragenol derivative synthesis. Astragenol derivatives are promising anti-inflammatory agents for prostate cancer research[1].

Molecular Weight

490.72

Formula

C30H50O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@]([C@](O[C@@H]1C(C)(O)C)(CC1)C)([H])[C@H]2O)(CC=C([C@]([C@]3([H])C4(C)C)(CC[C@@H]4O)C)[C@@]5([H])C[C@@H]3O)[C@]5(C2)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (101.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0378 mL 10.1891 mL 20.3782 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2 mg/mL (4.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: 2 mg/mL (4.08 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.0378 mL 10.1891 mL 20.3782 mL 50.9455 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL 10.1891 mL
10 mM 0.2038 mL 1.0189 mL 2.0378 mL 5.0946 mL
15 mM 0.1359 mL 0.6793 mL 1.3585 mL 3.3964 mL
20 mM 0.1019 mL 0.5095 mL 1.0189 mL 2.5473 mL
25 mM 0.0815 mL 0.4076 mL 0.8151 mL 2.0378 mL
30 mM 0.0679 mL 0.3396 mL 0.6793 mL 1.6982 mL
40 mM 0.0509 mL 0.2547 mL 0.5095 mL 1.2736 mL
50 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0189 mL
60 mM 0.0340 mL 0.1698 mL 0.3396 mL 0.8491 mL
80 mM 0.0255 mL 0.1274 mL 0.2547 mL 0.6368 mL
100 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.5095 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astragenol86541-79-9Othersanti-inflammatoryprostatecancerintermediateInhibitorinhibitorinhibit

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