2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Spantide II

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Spantide II Chemical Structure

Spantide II Chemical Structure

CAS No. : 129176-97-2

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1 mg USD 115 In-stock
5 mg USD 285 In-stock
10 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

Spantide II Related Antibodies

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Description

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].

IC50 & Target[1]

NK1

 

Molecular Weight

1668.76

Formula

C86H104Cl2N18O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (59.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5992 mL 2.9962 mL 5.9925 mL
5 mM 0.1198 mL 0.5992 mL 1.1985 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5992 mL 2.9962 mL 5.9925 mL 14.9812 mL
5 mM 0.1198 mL 0.5992 mL 1.1985 mL 2.9962 mL
10 mM 0.0599 mL 0.2996 mL 0.5992 mL 1.4981 mL
15 mM 0.0399 mL 0.1997 mL 0.3995 mL 0.9987 mL
20 mM 0.0300 mL 0.1498 mL 0.2996 mL 0.7491 mL
25 mM 0.0240 mL 0.1198 mL 0.2397 mL 0.5992 mL
30 mM 0.0200 mL 0.0999 mL 0.1997 mL 0.4994 mL
40 mM 0.0150 mL 0.0749 mL 0.1498 mL 0.3745 mL
50 mM 0.0120 mL 0.0599 mL 0.1198 mL 0.2996 mL
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Spantide II Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spantide II129176-97-2Neurokinin ReceptorNK receptorTachykinin receptorAnti-inflammatorypsoriasiscontact dermatitissubstance PInhibitorinhibitorinhibit

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