129176-97-2
Chemical Structure
Spantide II
- CAS No.: 129176-97-2
- Formula:C86H104Cl2N18O13
- Molecular Weight:1668.76
IUPAC Name: (S)-N1-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-1-amino-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-((R)-3-(3,4-dichlorophenyl)-2-((S)
InChIKey: VJPWTVLSHIDVRH-XCHUDMFJSA-N
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC2=CNC3=CC=CC=C23)=O)[C@H](NC([C@H](CC(N)=O)NC([C@H](NC([C@H](CCC4)N4C([C@H](CC5=CN=CC=C5)NC([C@H](CCC6)N6C([C@H](N)CCCCNC(C7=CN=CC=C7)=O)=O)=O)=O)=O)CC(C=C8)=CC(Cl)=C8Cl)=O)=O)CC9=CNC%10=CC=CC=C9%10
Biological Activity: Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Spantide II | 99.47% | Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis. | ||||||||||||||||||||
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- [1]. Xu XJ, et al. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience. 1991;42(3):731-7. [Content Brief]
- [2]. Kikwai L, et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech. 2005 Oct 31;6(4):E565-72. [Content Brief]
- [3]. Babu RJ, et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm Res. 2004 Jan;21(1):108-13. [Content Brief]
Keywords
