2. Anti-infection
  3. Bacterial Parasite
  4. Tritrpticin

Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against *Trichomonas vaginalis*, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia.

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Tritrpticin

Tritrpticin Chemical Structure

CAS No. : 179264-81-4

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Tritrpticin Related Antibodies

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Description

Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against *Trichomonas vaginalis*, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia[1][2][3][4].

In Vitro

Tritrpticin (8-64 μg/mL; 16 h) inhibits the growth of E. coli, S. typhimurium, P. aeruginosa, and C. albicans with an MIC of 32 μg/mL, B. subtilis and S. epidermidis with an MIC of 8 μg/mL, and S. aureus with an MIC of 16 μg/mL[1].
Tritrpticin (100 μg/mL; 1 h) induces 37% hemolysis of human red blood cells at a concentration of 100 μg/mL[1].
Tritrpticin (8 μg/mL; 2 min) induces 74% Calcein (HY-D0040) leakage from POPC/POPG (3:1) liposomes at a concentration of 8 μg/mL[1].
Tritrpticin (2.0-16 mg/L; 18 h) exhibits in vitro antibacterial activity against E. coli (MIC 2.0-8.0 mg/L) and E. faecalis (MIC 4-16 mg/L)[3].
Tritrpticin (10-40 μM; 24 h for Jurkat cells, PBMCs; 4 h for RBCs) potently induces cytotoxicity in Jurkat T-leukemia cells (IC50 = 18.3 μM) and exhibits lower toxicity towards normal PBMCs (IC50 = 40.6 μM) and minimal hemolytic activity against RBCs (IC50 ≥ 65 μM)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tritrpticin Related Antibodies

Cell Cytotoxicity Assay[4]

Cell Line: Jurkat T-leukemia cells, primary peripheral blood mononuclear cells (PBMCs), red blood cells (RBCs)
Concentration: 10-40 μM
Incubation Time: 24 h (Jurkat cells, PBMCs); 4 h (RBCs)
Result: Exhibited cytotoxicity towards Jurkat cells with an IC50 of 18.3 μM.
Showed cytotoxicity towards PBMCs with an IC50 of 40.6 μM.
Induced hemolysis towards RBCs with an IC50 ≥ 65 μM.
In Vivo

Tritrpticin (1 mg/kg; i.p.; single dose) produces significant reductions in plasma endotoxin, IL-6, and TNF-α levels in LPS-induced septic shock in Wistar rats[3].
Tritrpticin (1 mg/kg; i.v.; single dose) reduces 72-hour lethality to 35% and significantly lowers bacterial burdens in multiple tissues and plasma inflammatory mediator levels in cecal ligation and puncture-induced septic shock in Wistar rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (adult male, 200-300 g, LPS-induced septic shock)[3]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Reduced plasma endotoxin to ≤0.015 EU/mL.
Reduced plasma IL-6 to 213.20 pg/mL.
Reduced plasma TNF-α to 0.26 ng/mL.
Animal Model: Wistar (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)[3]
Dosage: 1 mg/kg
Administration: i.v.; single dose
Result: Reduced 72-hour lethality to 35%.
Reduced bacterial count in blood to 8.8×105 CFU/mL.
Reduced bacterial count in peritoneum to 8.2×107 CFU/mL.
Reduced bacterial count in spleen to 7.0×106 CFU/mL.
Reduced bacterial count in liver to 7.4×106 CFU/mL.
Reduced bacterial count in mesenteric lymph nodes to 5.5×107 CFU/mL.
Produced significant reductions in plasma endotoxin, IL-6, and TNF-α levels.
Molecular Weight

1902.25

Formula

C96H132N28O14
CAS No.
Sequence

Val-Arg-Arg-Phe-Pro-Trp-Trp-Trp-Pro-Phe-Leu-Arg-Arg
Sequence Shortening

VRRFPWWWPFLRR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tritrpticin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tritrpticin179264-81-4BacterialParasiteB. subtilisC. albicansP. aeruginosaS. epidermidisE. coliseptic shockS. aureusTrichomonas vaginalisJurkat T cell leukemia cellsS. typhimuriumInhibitorinhibitorinhibit

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