1. Anti-infection
    Apoptosis
  2. Bacterial
    Parasite
    Apoptosis
    Antibiotic
  3. Metronidazole

Metronidazole 

Cat. No.: HY-B0318 Purity: 99.86%
COA Handling Instructions

Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections.

For research use only. We do not sell to patients.

Metronidazole Chemical Structure

Metronidazole Chemical Structure

CAS No. : 443-48-1

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Metronidazole:

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Description

Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].

In Vitro

Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli[1].
Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity[1].
Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Blastocystis sp. Cells
Concentration: 0.1 μg/mL-0.01 mg/mL
Incubation Time: 12, 24, 48, 60, 72, 84, 96 hours
Result: Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage.
In Vivo

Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats[3].
Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (200-220 g)[3]
Dosage: 135 mg/kg
Administration: Oral gavage; once daily; 28 days
Result: Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.
Animal Model: SPF C57Bl/6J mice (6-7 months old)[4]
Dosage: 1 g/L
Administration: Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result: Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing.
Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.
Clinical Trial
Molecular Weight

171.15

Formula

C6H9N3O3

CAS No.
SMILES

OCCN1C([N+]([O-])=O)=CN=C1C

Structure Classification
Source

Gram-negative and Gram-positive anaerobic

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (204.50 mM; Need ultrasonic and warming)

H2O : 16.67 mg/mL (97.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8428 mL 29.2141 mL 58.4283 mL
5 mM 1.1686 mL 5.8428 mL 11.6857 mL
10 mM 0.5843 mL 2.9214 mL 5.8428 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 12.5 mg/mL (73.04 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (12.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (12.15 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (12.15 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.86%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Metronidazole
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