1. Anti-infection
    Apoptosis
  2. Bacterial
    Parasite
    Apoptosis
  3. Metronidazole

Metronidazole 

Cat. No.: HY-B0318 Purity: 97.70%
Handling Instructions

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.

For research use only. We do not sell to patients.

Metronidazole Chemical Structure

Metronidazole Chemical Structure

CAS No. : 443-48-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g USD 96 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Target: Antibacterial; Antiparasitic Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal.[1] It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection [2]. Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Once taken up by anaerobes, it is non-enzymatically reduced by reacting with reduced ferredoxin, which is generated by pyruvate oxido-reductase. Many of the reduced nitroso intermediates will form sulfinamides and thioether linkages with cysteine-bearing enzymes, thereby deactivating these critical enzymes. As many as 150 separate enzymes are affected.In addition or alternatively, the metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic cells, it has relatively little effect upon human cells or aerobic bacteria.[3]

Clinical Trial
Molecular Weight

171.15

Formula

C₆H₉N₃O₃

CAS No.

443-48-1

SMILES

OCCN1C([N+]([O-])=O)=CN=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (204.50 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8428 mL 29.2141 mL 58.4283 mL
5 mM 1.1686 mL 5.8428 mL 11.6857 mL
10 mM 0.5843 mL 2.9214 mL 5.8428 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MetronidazoleBacterialParasiteApoptosisInhibitorinhibitorinhibit

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