Metronidazole hydrochloride (Synonyms: SC 326421)

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Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application.

For research use only. We do not sell to patients.

Metronidazole hydrochloride Chemical Structure

CAS No. : 69198-10-3

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Other In-stock Forms of Metronidazole hydrochloride:

Other Forms of Metronidazole hydrochloride:

Metronidazole In-stock
Metronidazole-d₄ hydrochloride Get quote

23 Publications Citing Use of MCE Metronidazole hydrochloride

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Description

In Vitro

Metronidazole hydrochloride acts on anaerobic microorganism following: passage through the cell membrane; (b) reductive action; (c) interaction with intracellular targets; (d) release of inactive end products, exerts function with toxic nitro and nitroso derivatives^[1].
Metronidazole hydrochloride displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli^[1].
Metronidazole hydrochloride (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity^[1].
Metronidazole hydrochloride (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:	Blastocystis sp. Cells
Concentration:	0.1 μg/mL-0.01 mg/mL
Incubation Time:	12, 24, 48, 60, 72, 84, 96 hours
Result:	Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage.

In Vivo

Metronidazole hydrochloride (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats^[3].
Metronidazole hydrochloride (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (SD) rats (200-220 g)^[3]
Dosage:	135 mg/kg
Administration:	Oral gavage; once daily; 28 days
Result:	Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.

Animal Model:	SPF C57Bl/6J mice (6-7 months old)^[4]
Dosage:	1 g/L (full dose)
Administration:	Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result:	Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing. Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.

Clinical Trial

Molecular Weight

207.61

Formula

C₆H₁₀ClN₃O₃

CAS No.

69198-10-3

SMILES

OCCN1C([N+]([O-])=O)=CN=C1C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21. [Content Brief]

[2]. Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390. [Content Brief]

[3]. Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10. [Content Brief]

[4]. Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. [Content Brief]

Metronidazole hydrochloride Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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