2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. [D-Arg1,D-Trp5,7,9,Leu11]-Substance P

[D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice.

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[D-Arg1,D-Trp5,7,9,Leu11]-Substance P

[D-Arg1,D-Trp5,7,9,Leu11]-Substance P Chemical Structure

CAS No. : 122481-75-8

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[D-Arg1,D-Trp5,7,9,Leu11]-Substance P Related Antibodies

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Description

[D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice[1].

Molecular Weight

1555.87

Formula

C81H110N20O12
CAS No.
Sequence

{d-Arg}-Pro-Lys-Pro-{d-Trp}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2
Sequence Shortening

{d-Arg}-PPKP-{d-Trp}-Q-{d-Trp}-F-{d-Trp}-LL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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[D-Arg1,D-Trp5,7,9,Leu11]-Substance P Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Arg1,D-Trp5,7,9,Leu11]-Substance P122481-75-8Neurotensin ReceptorSubstance P analoguesmall cell lung cancerneuroendocrine peptide antagonistD-Arg1 D-Trp5,7,9 Leu11 substitutionantiproliferative activitycalcium mobilizationMAPK pathway inhibitionxenograft modelvasopressinbradykininInhibitorinhibitorinhibit

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