[D-Pro2,D-Trp7,9] Substance P
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist.
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- CAS. Nr.: 80434-86-2
- Formel: C74H106N20O13S
- Molecular Weight:1515.82
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[D-Pro2,D-Trp7,9] Substance P Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3808.gif "Click to View [D-Pro2,D-Trp7,9] Substance P Chemical Structure")
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
[D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 μM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult pigmented rabbits (1.5-3 kg)[1]
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Dosage:0.03, 0.3, 3, and 30 nmol
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Administration:Intravitreal injection or topical application onto the eye, 60 μL
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Result:Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
Chemical Information
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CAS. Nr. 80434-86-2
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Molecular Weight 1515.82
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Formel C74H106N20O13S
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Sequence Shortening
RPKPQQWFWLM-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Reinheit & Dokumentation
Verweise
[1]. Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. [Content Brief]
[2]. Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. [Content Brief]
[3]. Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
[D-Pro2,D-Trp7,9] Substance P Related Classifications
HY-P3808 Related Classifications
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