[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Art. -Nr.: HY-103544 Reinheit: 98.48%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Kundenspezifische Peptidsynthese

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemische Struktur

CAS. Nr. : 96736-12-8

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Interleukin Related Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Alle JNK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

JNK1 JNK2 JNK3 JNK

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	18 nM Compound: rPKPfQwFwLL-NH2	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	[PMID: 17371869]
COS-7	IC₅₀	3.2 nM Compound: rPKPfQwFwLL-NH2	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	[PMID: 17371869]

Molekulargewicht

1516.83

Formel

C₇₉H₁₀₉N₁₉O₁₂

CAS. Nr.

96736-12-8

Appearance

Solid

Color

White to off-white

Sequence

{d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2

Sequence Shortening

{d-Arg}-PKP-{d-Phe}-Q-{d-Trp}-F-{d-Trp}-LL-NH2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (65.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6593 mL	3.2963 mL	6.5927 mL
5 mM	0.1319 mL	0.6593 mL	1.3185 mL
10 mM	0.0659 mL	0.3296 mL	0.6593 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.48%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (256 KB) RP-HPLC (111 KB) MS (257 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [Content Brief]

[2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6593 mL	3.2963 mL	6.5927 mL	16.4817 mL
	5 mM	0.1319 mL	0.6593 mL	1.3185 mL	3.2963 mL
	10 mM	0.0659 mL	0.3296 mL	0.6593 mL	1.6482 mL
	15 mM	0.0440 mL	0.2198 mL	0.4395 mL	1.0988 mL
	20 mM	0.0330 mL	0.1648 mL	0.3296 mL	0.8241 mL
	25 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	30 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5494 mL
	40 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.4120 mL
	50 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3296 mL
	60 mM	0.0110 mL	0.0549 mL	0.1099 mL	0.2747 mL