[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
Based on 1 Customer Validation
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 96736-12-8
- Formula: C79H109N19O12
- Molecular Weight:1516.83
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
![[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemical Structure](https://file.medchemexpress.com/product_pic/hy-103544.gif "Click to View [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
18 nM
Compound: rPKPfQwFwLL-NH2
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Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation
Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation
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[PMID: 17371869] |
| COS-7 | IC50 |
3.2 nM
Compound: rPKPfQwFwLL-NH2
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Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells
Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells
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[PMID: 17371869] |
Chemical Information
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CAS No. 96736-12-8
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Appearance Solid
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Molecular Weight 1516.83
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Formula C79H109N19O12
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Color White to off-white
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Sequence
{d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2
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Sequence Shortening
{d-Arg}-PKP-{d-Phe}-Q-{d-Trp}-F-{d-Trp}-LL-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (65.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [Content Brief]
[2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6593 mL | 3.2963 mL | 6.5927 mL | 16.4817 mL |
| 5 mM | 0.1319 mL | 0.6593 mL | 1.3185 mL | 3.2963 mL | |
| 10 mM | 0.0659 mL | 0.3296 mL | 0.6593 mL | 1.6482 mL | |
| 15 mM | 0.0440 mL | 0.2198 mL | 0.4395 mL | 1.0988 mL | |
| 20 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8241 mL | |
| 25 mM | 0.0264 mL | 0.1319 mL | 0.2637 mL | 0.6593 mL | |
| 30 mM | 0.0220 mL | 0.1099 mL | 0.2198 mL | 0.5494 mL | |
| 40 mM | 0.0165 mL | 0.0824 mL | 0.1648 mL | 0.4120 mL | |
| 50 mM | 0.0132 mL | 0.0659 mL | 0.1319 mL | 0.3296 mL | |
| 60 mM | 0.0110 mL | 0.0549 mL | 0.1099 mL | 0.2747 mL |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Related Classifications
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