96736-12-8
![[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-103544.gif "[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemical Structure")
Chemical Structure
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
- CAS No.: 96736-12-8
- Formula:C79H109N19O12
- Molecular Weight:1516.83
IUPAC Name: (S)-2-((R)-2-((S)-1-(D-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-N1-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-o
InChIKey: XVOCEQLNJQGCQG-ACRSGXKRSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](CCC(N)=O)NC([C@@H](CC4=CC=CC=C4)NC([C@H]5N(CCC5)C([C@H](CCCCN)NC([C@H]6N(CCC6)C([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)=O
Biological Activity: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | 99.75% | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer | ||||||||||||||||||||
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- [1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [Content Brief]
- [2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63. [Content Brief]
