2. Apoptosis
  3. Apoptosis
  4. Beta-Sitosterol (purity>75%)

Beta-Sitosterol (purity>75%)  (Synonyms: β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%))

Cat. No.: HY-N0171B Purity: ≥95.0%
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Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities.

For research use only. We do not sell to patients.

Beta-Sitosterol (purity>75%) Chemical Structure

Beta-Sitosterol (purity>75%) Chemical Structure

CAS No. : 83-46-5

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Beta-Sitosterol (purity>75%) Related Antibodies

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Description

Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities[1][2][3].

In Vitro

Beta-Sitosterol purity>75% (16 μM, 1, 3, 5 days) can inhibit the growth of MDA-MB-231 human breast cancer cells and induce cell apoptosis[1].
Beta-Sitosterol purity>75% (120, 240 μM, 24 h) shows significant dose-dependent growth inhibition on COLO 320 DM cells (IC50 266.2 μM). The expression of β-catenin and PCNA antigens in human colon cancer cells was inhibited by scavenging reactive oxygen species to induce cell apoptosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Beta-Sitosterol (purity>75%) Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 3 days
Result: No cytotoxicity at 16 μM

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 5 days
Result: Increased 33% apoptosis when assayed using 1×104 cells and a 6-fold increase in apoptosis when assayed using a smaller number of cells 5×103.

Western Blot Analysis[2]

Cell Line: COLO 320 DM
Concentration: 15, 30, 60, 120 μM
Incubation Time: 24 h
Result: Decreased β-catenin and PCNA expression.
In Vivo

Beta-Sitosterol purity>75% (10-20 mg/kg, suspended in 0.1% CMC, orally, once a day for 16 weeks) can prevent cancer in the rat model of colon cancer[2].
Beta-Sitosterol purity>75% (10, 15, 20 mg/kg, orally, for 21 consecutive days) has anti-hyperglycemic and antioxidant effects in streptozotocin (HY-13753) induced experimental hyperglycemic rat models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon cancer rats model [2]
Dosage: 10, 20 mg/kg
Administration: p.o., suspended in 0.1% CMC (1.0 mL)
Result: Reduced the number of aberrant crypt and crypt multiplicity in a dose-dependent manner.
Animal Model: Streptozotocin-induced hyperglycemia rats model[3]
Dosage: 10, 15, 20 mg/kg
Administration: p.o.
Result: Increased insulin levels and decreased HbA1c levels.
Improved pancreatic antioxidant levels and decreased LPO levels.
Molecular Weight

414.71

Formula

C29H50O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@@H](C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

COA (248 KB)

Handling Instructions (2659 KB)
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Beta-Sitosterol (purity>75%) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beta-Sitosterol (purity>75%)83-46-5β-Sitosterol (purity>75%) 22,23-Dihydrostigmasterol (purity>75%)ApoptosisMDA-MB-231COLO 320 DMColon cancer rats modelStreptozotocin-induced hyperglycemiaInhibitorinhibitorinhibit

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