Immunoproteasome inhibitor 1

Name: Immunoproteasome inhibitor 1
Brand: MedChemExpress
SKU: HY-144452
Rating: 4.5 (1 reviews)

Cat. No.: HY-144452 Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions

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Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (K_is of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases.

For research use only. We do not sell to patients.

Immunoproteasome inhibitor 1 Chemical Structure

CAS No. : 2755772-63-3

Size	Price	Stock	Quantity
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 465	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 920	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1480	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

β5c submit

1.18 μM (Ki)

β1i submit

0.27 μM (Ki)

β2i submit

20 μM (Ki)

β5i submit

1.91 μM (Ki)

In Vitro

Immunoproteasome inhibitor 1 (compound 9) (0-25 μM; 0-600 seconds; in Human 20S immunoproteasome and human 20S proteasome) has high binding affinity for the β1i subunit (0.27 µM) of immunoproteasome and proteasome, coupling with good inhibitory properties towards β5i and β5c subunits. And the results of against the β5i subunit shows that the inhibition is reversible, time-independent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.43

Formula

C₂₀H₂₆N₂O₄

CAS No.

2755772-63-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC(OC)=C(OC)C=C2C=CN1C/C=C/C(NCCC(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (278.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7899 mL	13.9497 mL	27.8995 mL
5 mM	0.5580 mL	2.7899 mL	5.5799 mL
10 mM	0.2790 mL	1.3950 mL	2.7899 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (244 KB) HNMR (260 KB) CNMR (268 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Ettari R, et al. Development of isoquinolinone derivatives as immunoproteasome inhibitors. Bioorg Med Chem Lett. 2022;55:128478. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7899 mL	13.9497 mL	27.8995 mL	69.7486 mL
	5 mM	0.5580 mL	2.7899 mL	5.5799 mL	13.9497 mL
	10 mM	0.2790 mL	1.3950 mL	2.7899 mL	6.9749 mL
	15 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6499 mL
	20 mM	0.1395 mL	0.6975 mL	1.3950 mL	3.4874 mL
	25 mM	0.1116 mL	0.5580 mL	1.1160 mL	2.7899 mL
	30 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3250 mL
	40 mM	0.0697 mL	0.3487 mL	0.6975 mL	1.7437 mL
	50 mM	0.0558 mL	0.2790 mL	0.5580 mL	1.3950 mL
	60 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	80 mM	0.0349 mL	0.1744 mL	0.3487 mL	0.8719 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6975 mL