1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Immunoproteasome inhibitor 1

Immunoproteasome inhibitor 1 

Cat. No.: HY-144452
Handling Instructions

Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the treatment of certain neoplastic diseases.

For research use only. We do not sell to patients.

Immunoproteasome inhibitor 1 Chemical Structure

Immunoproteasome inhibitor 1 Chemical Structure

CAS No. : 2755772-63-3

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Description

Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the treatment of certain neoplastic diseases[1].

IC50 & Target

β5c submit

1.18 μM (Ki)

β1i submit

0.27 μM (Ki)

β2i submit

20 μM (Ki)

β5i submit

1.91 μM (Ki)

In Vitro

Immunoproteasome inhibitor 1 (compound 9) (0-25 μM; 0-600 seconds; in Human 20S immunoproteasome and human 20S proteasome) has high binding affinity for the β1i subunit (0.27 µM) of immunoproteasome and proteasome, coupling with good inhibitory properties towards β5i and β5c subunits. And the results of against the β5i subunit shows that the inhibition is reversible, time-independent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.43

Formula

C20H26N2O4

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Immunoproteasome inhibitor 1
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HY-144452
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