2. NF-κB
  3. NF-κB
  4. 3'-Sialyllactose

3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

For research use only. We do not sell to patients.

3'-Sialyllactose Chemical Structure

3'-Sialyllactose Chemical Structure

CAS No. : 35890-38-1

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3'-Sialyllactose Related Antibodies

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Description

3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3].

In Vitro

3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3'-Sialyllactose (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].
3'-Sialyllactose (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3'-Sialyllactose Related Antibodies

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 0, 50, 100 and 250 μM
Incubation Time: 24-36 hours
Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
In Vivo

3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3'-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3'-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1]
Dosage: 10, 50 and 100 mg/kg
Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
Molecular Weight

633.55

Formula

C23H39NO19
CAS No.
SMILES

OC([C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)O)=O
Structure Classification
Initial Source

Human milk
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3'-Sialyllactose Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Sialyllactose35890-38-13'-SLNF-κBNuclear factor-κBNuclear factor-kappaBpolysaccharideprebiotichomeostasisinflammationimmuneCol2a1osteoarthritismiceInhibitorinhibitorinhibit

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