Cat. No.: HY-108065A

3'-Sialyllactose sodium

(Synonyms: 3'-SL sodium)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

For research use only. We do not sell to patients.

Purity: 99.89%
CAS No.: 128596-80-5
Formula: C₂₃H₃₈NNaO₁₉
Molecular Weight:655.53

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

3'-Sialyllactose sodium Chemical Structure

CAS No.: 128596-80-5

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NF-κB Isoforms :

In Vitro

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines^[1].
3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes^[1].
3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation^[3].
3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Chondrocytes
Concentration:

0, 50, 100 and 250 μM
Incubation Time:

24-36 hours
Result:

Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

In Vivo

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis^[1].
3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice^[3].
3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs^[3].
3'-Sialyllactose sodium shows a lethal dose (LD₅₀) above 20 g/kg bw, the highest dose tested^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old male C57BL/6 mice with medial meniscus surgery^[1]
Dosage:

10, 50 and 100 mg/kg
Administration:

Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result:

Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

Chemical Information

CAS No. 128596-80-5
Appearance Solid
Molecular Weight 655.53
Formula C₂₃H₃₈NNaO₁₉
Color White to off-white
SMILES

O=C(O[Na])[C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)O
Synonyms

3'-SL sodium
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Animals
human milk
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Future Sci OA

The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]

2026 Dec;12(1):2622241. PMID: 41622772

Solvent & Solubility

In Vitro:

H₂O : 233.33 mg/mL (355.94 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5255 mL

7.6274 mL

15.2548 mL

5 mM

0.3051 mL

1.5255 mL

3.0510 mL

10 mM

0.1525 mL

0.7627 mL

1.5255 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66. [Content Brief]

[2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603. [Content Brief]

[3]. Kim D, et al. Toxicological evaluation of 3'-sialyllactose sodium salt. Regul Toxicol Pharmacol. 2018 Apr;94:83-90. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5255 mL	7.6274 mL	15.2548 mL	38.1371 mL
	5 mM	0.3051 mL	1.5255 mL	3.0510 mL	7.6274 mL
	10 mM	0.1525 mL	0.7627 mL	1.5255 mL	3.8137 mL
	15 mM	0.1017 mL	0.5085 mL	1.0170 mL	2.5425 mL
	20 mM	0.0763 mL	0.3814 mL	0.7627 mL	1.9069 mL
	25 mM	0.0610 mL	0.3051 mL	0.6102 mL	1.5255 mL
	30 mM	0.0508 mL	0.2542 mL	0.5085 mL	1.2712 mL
	40 mM	0.0381 mL	0.1907 mL	0.3814 mL	0.9534 mL
	50 mM	0.0305 mL	0.1525 mL	0.3051 mL	0.7627 mL
	60 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6356 mL
	80 mM	0.0191 mL	0.0953 mL	0.1907 mL	0.4767 mL
	100 mM	0.0153 mL	0.0763 mL	0.1525 mL	0.3814 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

3'-Sialyllactose sodium

1 Cited Publications

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3'-Sialyllactose sodium

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Publications Citing Use of MedChemExpress (MCE) 3'-Sialyllactose sodium

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

3'-Sialyllactose sodium Related Classifications

HY-108065A Related Classifications