1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. CCR6 antagonist 1

CCR6 antagonist 1 

Cat. No.: HY-151435
Handling Instructions

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

For research use only. We do not sell to patients.

CCR6 antagonist 1 Chemical Structure

CCR6 antagonist 1 Chemical Structure

CAS No. : 588674-64-0

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Description

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1].

IC50 & Target[1]

CCR6

 

In Vitro

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration[1].
CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [1]

Cell Line: CCL20 (500 ng/mL)-induced CCR6+CD4+ T cell
Concentration: 0.5, 5, 50 μM
Incubation Time: 3 h
Result: Inhibited CCL20-induced cell migration at 50 μM.
In Vivo

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine model of colitis (5 mg/mouse TNBS-induced)[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection (s.c.), twice daily for 3 days.
Result: Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.
Animal Model: Zymosan-induced peritonitis mice[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result: Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.
Molecular Weight

319.28

Formula

C17H12F3NO2

CAS No.
SMILES

O=C(C1=C(C)C2=CC=CC=C2O1)NC3=CC=C(C(F)(F)F)C=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CCR6 antagonist 1
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HY-151435
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