2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR6 antagonist 1

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

For research use only. We do not sell to patients.

CAS No. : 588674-64-0

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

CCR6 antagonist 1 Related Antibodies

Top Publications Citing Use of Products

    CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 13;16(1):2493.  [Abstract]

    CCR6 antagonist 1 (50 μM). The effects of the inhibitor on each pathway were assessed by IPA analysis, and its effect on HE cell expansion after 7 days was observed.

    CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Transl Res. 2025 Sep 11:S1931-5244(25)00089-1.  [Abstract]

    The number of migrating NCAPB and DSSAPB cells with or without CCR6 antagonist 1 treatment.

    CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111332.  [Abstract]

    Transwell migration assay: PBMCs isolated from MPE patients were placed in the upper chamber, and different conditions (medium, PE, MPE, MPE + CCR2 antagonist, MPE + CCR5 antagonist, or MPE + CCR6 antagonist 1 (20 μg/mL) ) were placed in the lower chamber.

    View All CCR Isoform Specific Products:

    View All Isoforms
    CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1].

    IC50 & Target[1]

    CCR6

     

    In Vitro

    CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration[1].
    ? CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CCR6 antagonist 1 Related Antibodies

    Cell Migration Assay [1]

    Cell Line: CCL20 (500 ng/mL)-induced CCR6+CD4+ T cell
    Concentration: 0.5, 5, 50 μM
    Incubation Time: 3 h
    Result: Inhibited CCL20-induced cell migration at 50 μM.
    In Vivo

    CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
    ? CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
    in Zymosan-induced peritonitis mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Murine model of colitis (5 mg/mouse TNBS-induced)[1]
    Dosage: 1 mg/kg
    Administration: Subcutaneous injection (s.c.), twice daily for 3 days.
    Result: Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.
    Animal Model: Zymosan-induced peritonitis mice[1]
    Dosage: 1 mg/kg
    Administration: Subcutaneous injection (s.c.), twice, before and after zymosan treatment
    Result: Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.
    Molecular Weight

    319.28

    Formula

    C17H12F3NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=C(C)C2=CC=CC=C2O1)NC3=CC=C(C(F)(F)F)C=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1320 mL 15.6602 mL 31.3205 mL
    5 mM 0.6264 mL 3.1320 mL 6.2641 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 1 mg/mL (3.13 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1320 mL 15.6602 mL 31.3205 mL 78.3012 mL
    5 mM 0.6264 mL 3.1320 mL 6.2641 mL 15.6602 mL
    10 mM 0.3132 mL 1.5660 mL 3.1320 mL 7.8301 mL
    15 mM 0.2088 mL 1.0440 mL 2.0880 mL 5.2201 mL
    20 mM 0.1566 mL 0.7830 mL 1.5660 mL 3.9151 mL
    25 mM 0.1253 mL 0.6264 mL 1.2528 mL 3.1320 mL
    30 mM 0.1044 mL 0.5220 mL 1.0440 mL 2.6100 mL
    40 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9575 mL
    50 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5660 mL
    60 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3050 mL
    80 mM 0.0392 mL 0.1958 mL 0.3915 mL 0.9788 mL
    100 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.7830 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    CCR6 antagonist 1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CCR6 antagonist 1588674-64-0CCRCC chemokine receptorImmuneCCL20autoimmuneIBDsmigrationT cellcolitisInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    CCR6 antagonist 1
    Cat. No.:
    HY-151435
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.