Art. -Nr.: HY-151435

CCR6 antagonist 1

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

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Reinheit: 99.30%
CAS. Nr.: 588674-64-0
Formel: C₁₇H₁₂F₃NO₂
Molecular Weight:319.28

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CCR6 antagonist 1 Chemical Structure

CAS. Nr.: 588674-64-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CCR6

Alle CCR Isoform-spezifische Produkte anzeigen :

In Vitro

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4⁺ T cell migration^[1].
? CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

CCL20 (500 ng/mL)-induced CCR6⁺CD4⁺ T cell
Concentration:

0.5, 5, 50 μM
Incubation Time:

3 h
Result:

Inhibited CCL20-induced cell migration at 50 μM.

In Vivo

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice^[1].
? CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Murine model of colitis (5 mg/mouse TNBS-induced)^[1]
Dosage:

1 mg/kg
Administration:

Subcutaneous injection (s.c.), twice daily for 3 days.
Result:

Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.

Animal Model:

Zymosan-induced peritonitis mice^[1]
Dosage:

1 mg/kg
Administration:

Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result:

Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.

Chemical Information

CAS. Nr. 588674-64-0
Appearance Solid
Molecular Weight 319.28
Formel C₁₇H₁₂F₃NO₂
Color White to off-white
SMILES

O=C(C1=C(C)C2=CC=CC=C2O1)NC3=CC=C(C(F)(F)F)C=C3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All OthersCell Migration/Invasion Assay

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Journal Impact Factor

Nat Commun

Placenta-derived factors contribute to human iPSC-liver organoid growth. [Abstract]

2025 Mar 13;16(1):2493. PMID: 40082402

CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 13;16(1):2493. [Abstract]

CCR6 antagonist 1 (50 μM). The effects of the inhibitor on each pathway were assessed by IPA analysis, and its effect on HE cell expansion after 7 days was observed.
Transl Res

Appendiceal B lymphocytes contribute to the pathogenesis of experimental colitis through fueling colonic CD4+ T polarization. [Abstract]

2025 Sep 11:S1931-5244(25)00089-1. PMID: 40945653

CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Transl Res. 2025 Sep 11:S1931-5244(25)00089-1. [Abstract]

The number of migrating NCAPB and DSSAPB cells with or without CCR6 antagonist 1 treatment.
Int Immunopharmacol

C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion. [Abstract]

2024 Jan 25:127:111332. PMID: 38071913

CCR6 antagonist 1 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111332. [Abstract]

Transwell migration assay: PBMCs isolated from MPE patients were placed in the upper chamber, and different conditions (medium, PE, MPE, MPE + CCR2 antagonist, MPE + CCR5 antagonist, or MPE + CCR6 antagonist 1 (20 μg/mL) ) were placed in the lower chamber.
FASEB J

Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease. [Abstract]

2024 Jan 31;38(2):e23407. PMID: 38197598

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1320 mL

15.6602 mL

31.3205 mL

5 mM

0.6264 mL

3.1320 mL

6.2641 mL

10 mM

0.3132 mL

1.5660 mL

3.1320 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1 mg/mL (3.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1320 mL	15.6602 mL	31.3205 mL	78.3012 mL
	5 mM	0.6264 mL	3.1320 mL	6.2641 mL	15.6602 mL
	10 mM	0.3132 mL	1.5660 mL	3.1320 mL	7.8301 mL
	15 mM	0.2088 mL	1.0440 mL	2.0880 mL	5.2201 mL
	20 mM	0.1566 mL	0.7830 mL	1.5660 mL	3.9151 mL
	25 mM	0.1253 mL	0.6264 mL	1.2528 mL	3.1320 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6100 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9575 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5660 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3050 mL
	80 mM	0.0392 mL	0.1958 mL	0.3915 mL	0.9788 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7830 mL

Keywords

CCR6 antagonist 1

4 Cited Publications

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CCR6 antagonist 1

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Publications Citing Use of MedChemExpress (MCE) CCR6 antagonist 1

Alle CCR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CCR6 antagonist 1

Bioactive Compound Library Max

Bioactive Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Pulmonary Fibrosis Compound Library

Chemokine Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cytokine Inhibitors Library

MCE Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) CCR6 antagonist 1

Alle CCR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CCR6 antagonist 1 Related Classifications

HY-151435 Related Classifications