CCR6 antagonist 1

Name: CCR6 antagonist 1
Brand: MedChemExpress
SKU: HY-151435
Rating: 4.5 (2 reviews)

Cat. No.: HY-151435 Purity: 99.55%: FAQs
Data Sheet SDS COA Handling Instructions

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CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

For research use only. We do not sell to patients.

CCR6 antagonist 1 Chemical Structure

CAS No. : 588674-64-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 99	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE CCR6 antagonist 1

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

CCR6

In Vitro

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4⁺ T cell migration^[1].
? CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:	CCL20 (500 ng/mL)-induced CCR6⁺CD4⁺ T cell
Concentration:	0.5, 5, 50 μM
Incubation Time:	3 h
Result:	Inhibited CCL20-induced cell migration at 50 μM.

In Vivo

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice^[1].
? CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine model of colitis (5 mg/mouse TNBS-induced)^[1]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection (s.c.), twice daily for 3 days.
Result:	Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.

Animal Model:	Zymosan-induced peritonitis mice^[1]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result:	Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.

Molecular Weight

319.28

Formula

C₁₇H₁₂F₃NO₂

CAS No.

588674-64-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C2=CC=CC=C2O1)NC3=CC=C(C(F)(F)F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1320 mL	15.6602 mL	31.3205 mL
5 mM	0.6264 mL	3.1320 mL	6.2641 mL
10 mM	0.3132 mL	1.5660 mL	3.1320 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (246 KB) HNMR (258 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1320 mL	15.6602 mL	31.3205 mL	78.3012 mL
	5 mM	0.6264 mL	3.1320 mL	6.2641 mL	15.6602 mL
	10 mM	0.3132 mL	1.5660 mL	3.1320 mL	7.8301 mL
	15 mM	0.2088 mL	1.0440 mL	2.0880 mL	5.2201 mL
	20 mM	0.1566 mL	0.7830 mL	1.5660 mL	3.9151 mL
	25 mM	0.1253 mL	0.6264 mL	1.2528 mL	3.1320 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6100 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9575 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5660 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3050 mL
	80 mM	0.0392 mL	0.1958 mL	0.3915 mL	0.9788 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7830 mL