Cefazolin sodium pentahydrate (Synonyms: Cephazolin sodium pentahydrate)

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Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD).

For research use only. We do not sell to patients.

Cefazolin sodium pentahydrate Chemical Structure

CAS No. : 115850-11-8

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6 Publications Citing Use of MCE Cefazolin sodium pentahydrate

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References
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Description

Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research^[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)^[2].

IC₅₀ & Target

β-lactam

In Vitro

Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide^[2].
Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation^[3].
Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	C8-B4 cells
Concentration:	0, 50, 100, 150, 200, 250, or 300 μg/ml
Incubation Time:	6 or 24 hours
Result:	Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml.

Cell Proliferation Assay^[3]

Cell Line:	PBMC, and TF-1 cells
Concentration:	0, 100, 200, and 400 μM
Incubation Time:	72 hours
Result:	Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γ_c.

Western Blot Analysis^[3]

Cell Line:	PBMC, NK-92, and TF-1 cells
Concentration:	0, 100, 200, and 400 μM
Incubation Time:	30 min
Result:	Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γ_c receptors.

In Vivo

Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy^[2]
Dosage:	300-500 mg/kg
Administration:	Subcutaneous injection; 300-500 mg/kg; once daily; 5 days
Result:	Attenuated learning and memory dysfunction induced by the surgery.

Clinical Trial

Molecular Weight

566.57

Formula

C₁₄H₂₃N₈NaO₉S₃

CAS No.

115850-11-8

SMILES

O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O[Na].O.O.O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6. [Content Brief]

[2]. Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235. [Content Brief]

[3]. Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10(1):2886. [Content Brief]

Cefazolin sodium pentahydrate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefazolin sodium115850-11-8Cephazolin sodiumAntibioticBacterialanti-inflammatory activitypost-operative cognitive dysfunctionPOCDC8-B4PBMCNK-92TF-1Inhibitorinhibitorinhibit

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