1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Cefazolin

Cefazolin 

Cat. No.: HY-B1892 Purity: 98.28%
Handling Instructions

Cefazolin is an antibiotic used for the research of a number of anti-bacterial infections. Cefazolin can be used for the prophylaxis of surgical antimicrobial. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD).

For research use only. We do not sell to patients.

Cefazolin Chemical Structure

Cefazolin Chemical Structure

CAS No. : 25953-19-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cefazolin is an antibiotic used for the research of a number of anti-bacterial infections. Cefazolin can be used for the prophylaxis of surgical antimicrobial. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[1].

IC50 & Target

Antibiotic[1]

In Vitro

Cefazolin (50-300 μg/mL; 6 or 24 hours) has a direct anti-inflammatory effect on C8-B4 cells stimulated by LPS (1 μg/mL)[1].

Cell Viability Assay[1]

Cell Line: Mouse C8-B4 microglial cells
Concentration: 50, 100, 150, 200, 250, and 300 μg/mL
Incubation Time: 6 or 24 hours
Result: Inhibited proinflammatory cytokine production.
Inhibited IL-6 production at 50 and 100 μg/mL.
In Vivo

Cefazolin (300 mg/kg; injected intraperitoneally 1 h before surgery and then once per day for 5 days after surgery) can attenuate surgery-induced post-operative memory and learning impairment in mice. Cefazolin alone may induce cognitive dysfunction possibly by transient gut dysbiosis in mice without surgery[1].

Animal Model: Six- to 8-week-old CD-1 male mice (weighing 31-36 g) [1]
Dosage: 300-500 mg/kg
Administration: 10 mg in 0.1 mL was intraperitoneally injected 30 min before surgery and then once every day for 5 days.
Result: Improved learning and memory after surgery and might impair learning and memory in mice without surgery.
Molecular Weight

454.51

Formula

C₁₄H₁₄N₈O₄S₃

CAS No.

25953-19-9

SMILES

O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[[email protected]]2([H])[[email protected]](NC(CN4N=NN=C4)=O)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (550.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2002 mL 11.0009 mL 22.0017 mL
5 mM 0.4400 mL 2.2002 mL 4.4003 mL
10 mM 0.2200 mL 1.1001 mL 2.2002 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CefazolinAntibioticBacterialantibioticanti-bacterialinfectionantimicrobialanti-inflammatorydysfunctionPOCDInhibitorinhibitorinhibit

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Cefazolin
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