2. Anti-infection
  3. Beta-lactamase Antibiotic Bacterial
  4. Clavulanic acid

Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias.

For research use only. We do not sell to patients.

CAS No. : 58001-44-8

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Clavulanic acid:

Clavulanic acid Related Antibodies

Top Publications Citing Use of Products

    Clavulanic acid purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017.  [Abstract]

    Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) did not change GLT-1 mRNA expression in the rat PFC.

    Clavulanic acid purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017.  [Abstract]

    Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) increased expression of GLT-1 protein in the rat PFC.

    Clavulanic acid purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.

    Average body weight at baseline and after treatment, by group. Two‑way ANOVA showed no significant differences between groups. n = 8–9 per group. Color dots represent individual data. CA (clavulanic acid, 5 mg/kg, i.p. for 7 days); DHK (dihydrokainic acid).

    Clavulanic acid purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.

    Post hoc comparisons using Tukey’s test indicated the total time spent in closed arms to be higher in the Khat and Khat‑CA‑DHK (CA: clavulanic acid, 5 mg/kg, i.p. for 7 days) groups as compared with the Control and Khat‑CA groups.

    Clavulanic acid purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.

    Clavulanic acid (5 mg/kg, i.p. for 7 days) reversed the Khat‑induced decrease in GLT‑1 and xCT expression in mice.

    View All Beta-lactamase Isoform Specific Products:

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    Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias[1].

    IC50 & Target

    β-lactam

     

    Cellular Effect
    Cell Line Type Value Description References
    Sf21 IC50
    > 1000 μM
    Compound: Clavulanate
    Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    		[PMID: 21965623]
    Sf21 IC50
    > 1000 μM
    Compound: Clavulanate
    Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    		[PMID: 21965623]
    In Vitro

    Clavulanic acid shows a synergistic antibacterial action (against β-lactamase-producing organisms) with Ampicillin[2].
    Clavulanic acid inhibits Ab11 and Ab51 strain with MICs of 2-8 μg/mL[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clavulanic acid Related Antibodies
    In Vivo

    Clavulanic acid (13 mg/kg, i.p.) decreases the bacterial load in the lung of an A. baumannii infected C57BL/6 mice pneumonia model[3].
    Clavulanic acid (13 mg/kg, i.p.) shows a t1/2 of 6.69 h, AUC of 4.03 mg·h/L in Ab51 infected C57BL/6 mice pneumonia model[3].
    Clavulanic acid (100-300 mg/kg, i.p.) shows anti-inflammatory effects on Carrageenan (HY-125474)-induced paw edema rats model[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    199.16

    Formula

    C8H9NO5
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 13.33 mg/mL (66.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 7 mg/mL (35.15 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.0211 mL 25.1054 mL 50.2109 mL
    5 mM 1.0042 mL 5.0211 mL 10.0422 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.33 mg/mL (6.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1.33 mg/mL (6.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.45%

    SDS (393 KB)

    COA (249 KB) HNMR (235 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 5.0211 mL 25.1054 mL 50.2109 mL 125.5272 mL
    5 mM 1.0042 mL 5.0211 mL 10.0422 mL 25.1054 mL
    10 mM 0.5021 mL 2.5105 mL 5.0211 mL 12.5527 mL
    15 mM 0.3347 mL 1.6737 mL 3.3474 mL 8.3685 mL
    20 mM 0.2511 mL 1.2553 mL 2.5105 mL 6.2764 mL
    25 mM 0.2008 mL 1.0042 mL 2.0084 mL 5.0211 mL
    30 mM 0.1674 mL 0.8368 mL 1.6737 mL 4.1842 mL
    DMSO 40 mM 0.1255 mL 0.6276 mL 1.2553 mL 3.1382 mL
    50 mM 0.1004 mL 0.5021 mL 1.0042 mL 2.5105 mL
    60 mM 0.0837 mL 0.4184 mL 0.8368 mL 2.0921 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Clavulanic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Clavulanic acid58001-44-8Beta-lactamaseAntibioticBacterialβ-lactamasegram-negative bacteriaantibioticdrug-resistant bacteriainactivation inhibitorInhibitorinhibitorinhibit

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