Clavulanate lithium

Name: Clavulanate lithium
Brand: MedChemExpress
SKU: HY-A0256B
Rating: 5.0 (8 reviews)

Cat. No.: HY-A0256B Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic.

For research use only. We do not sell to patients.

CAS No. : 61177-44-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Clavulanate lithium:

Clavulanic acid In-stock
Clavulanate potassium In-stock
Clavulanate lithium (Standard) Get quote

8 Publications Citing Use of MCE Clavulanate lithium

In Vivo Efficacy Study

RT-PCR

: Clavulanate lithium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]; Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) did not change GLT-1 mRNA expression in the rat PFC.

: Clavulanate lithium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]; Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) increased expression of GLT-1 protein in the rat PFC.

: Clavulanate lithium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Average body weight at baseline and after treatment, by group. Two‑way ANOVA showed no significant differences between groups. n = 8–9 per group. Color dots represent individual data. CA (clavulanic acid, 5 mg/kg, i.p. for 7 days); DHK (dihydrokainic acid).

: Clavulanate lithium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Post hoc comparisons using Tukey’s test indicated the total time spent in closed arms to be higher in the Khat and Khat‑CA‑DHK (CA: clavulanic acid, 5 mg/kg, i.p. for 7 days) groups as compared with the Control and Khat‑CA groups.

: Clavulanate lithium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Clavulanic acid (5 mg/kg, i.p. for 7 days) reversed the Khat‑induced decrease in GLT‑1 and xCT expression in mice.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic^[1]^[2].

IC₅₀ & Target

β-lactam

In Vitro

Clavulanate lithium has weak antibacterial activity against most organisms when administered alone, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase^[1].
Clavulanate lithium (0.25, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration (1 mg/L) is only marginally more effective than 0.5 mg/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	L. pneumophila NCTC 1119
Concentration:	0.25 mg/L, 0.5 mg/L, 1 mg/L
Incubation Time:	0-35 hours
Result:	Caused a relatively slow inhibition of growth.

Clinical Trial

Molecular Weight

205.09

Formula

C₈H₈LiNO₅

CAS No.

61177-44-4

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O[Li]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (162.51 mM; Need ultrasonic)

DMSO : 4.17 mg/mL (20.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8759 mL	24.3795 mL	48.7591 mL
5 mM	0.9752 mL	4.8759 mL	9.7518 mL
10 mM	0.4876 mL	2.4380 mL	4.8759 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (274 KB) SDS (480 KB)

COA (250 KB) HNMR (296 KB) RP-HPLC (237 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11(5): 852–857. [Content Brief]

[2]. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23(4):547-56. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.8759 mL	24.3795 mL	48.7591 mL	121.8977 mL
	5 mM	0.9752 mL	4.8759 mL	9.7518 mL	24.3795 mL
	10 mM	0.4876 mL	2.4380 mL	4.8759 mL	12.1898 mL
	15 mM	0.3251 mL	1.6253 mL	3.2506 mL	8.1265 mL
	20 mM	0.2438 mL	1.2190 mL	2.4380 mL	6.0949 mL
H₂O	25 mM	0.1950 mL	0.9752 mL	1.9504 mL	4.8759 mL
	30 mM	0.1625 mL	0.8127 mL	1.6253 mL	4.0633 mL
	40 mM	0.1219 mL	0.6095 mL	1.2190 mL	3.0474 mL
	50 mM	0.0975 mL	0.4876 mL	0.9752 mL	2.4380 mL
	60 mM	0.0813 mL	0.4063 mL	0.8127 mL	2.0316 mL
	80 mM	0.0609 mL	0.3047 mL	0.6095 mL	1.5237 mL
	100 mM	0.0488 mL	0.2438 mL	0.4876 mL	1.2190 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.