Clavulanate potassium
Based on 10 publication(s) in Google Scholar
Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 61177-45-5
- Formula: C8H8KNO5
- Molecular Weight:237.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Clavulanate potassium
More- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Int J Mol Sci. 2023 Oct 27;24(21):15657. [Abstract]
- Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]
- Antimicrob Agents Chemother. 2026 Jun 3;70(6):e0126725. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- Genomics. 2022 Nov;114(6):110527. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- bioRxiv. 2024 May 10.
Customer Validation & Images
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RT-PCR
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IF
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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WB
All Beta-lactamase Isoforms
MoreAll Antibiotic Isoforms
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Biological Activity
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β-lactam |
Clavulanate potassium has weak antibacterial activity against most organisms when administered alone, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase[1].
Clavulanate potassium (0.25 mg/L, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration (1 mg/L) is only marginally more effective than 0.5 mg/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61177-45-5
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Appearance Solid
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Molecular Weight 237.25
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Formula C8H8KNO5
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Color Light yellow to brown
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SMILES
O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O[K]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Int J Mol Sci
Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract. [Abstract]2023 Oct 27;24(21):15657. PMID: 37958641
Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657. [Abstract]
Average body weight at baseline and after treatment, by group. Two‑way ANOVA showed no significant differences between groups. n = 8–9 per group. Color dots represent individual data. CA (clavulanic acid, 5 mg/kg, i.p. for 7 days); DHK (dihydrokainic acid).
Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657. [Abstract]
Post hoc comparisons using Tukey’s test indicated the total time spent in closed arms to be higher in the Khat and Khat‑CA‑DHK (CA: clavulanic acid, 5 mg/kg, i.p. for 7 days) groups as compared with the Control and Khat‑CA groups.
Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657. [Abstract]
Clavulanic acid (5 mg/kg, i.p. for 7 days) reversed the Khat‑induced decrease in GLT‑1 and xCT expression in mice.
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Eur J Pharmacol
Positive allosteric modulation of glutamate transporter reduces cocaine-induced locomotion and expression of cocaine conditioned place preference in rats. [Abstract]2024 Dec 5:984:177017. PMID: 39349114
Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]
Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) did not change GLT-1 mRNA expression in the rat PFC.
Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]
Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) increased expression of GLT-1 protein in the rat PFC.
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Antimicrob Agents Chemother
Improved hydrolysis of piperacillin by OXA-48-like R214G variants, a selective advantage under piperacillin-tazobactam exposure. [Abstract]2026 Jun 3;70(6):e0126725. PMID: 42053451 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
Genomics
LRRK2 deficiency mitigates colitis progression by favoring resolution of inflammation and restoring homeostasis of gut microbiota. [Abstract]2022 Nov;114(6):110527. PMID: 36455749 -
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
Purity & Documentation
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Data Sheet (272 KB)
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SDS (570 KB)
- English - EN (570 KB)
- Français - FR (570 KB)
- Deutsch - DE (570 KB)
- Norwegian - NO (570 KB)
- Español - ES (570 KB)
- Swedish - SV (570 KB)
- Italian - IT (570 KB)
- Korean - KR (570 KB)
- Portuguese - PT (570 KB)
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Handling Instructions (2659 KB)
References
[1]. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11(5): 852–857. [Content Brief]
[2]. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23(4):547-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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