Clavulanate potassium

Name: Clavulanate potassium
Brand: MedChemExpress
SKU: HY-A0256A
Rating: 5.0 (8 reviews)

Cat. No.: HY-A0256A Purity: 99.86%: Data Sheet
COA

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Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic.

For research use only. We do not sell to patients.

CAS No. : 61177-45-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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100 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Clavulanate potassium:

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Clavulanic acid In-stock
Clavulanate lithium In-stock

8 Publications Citing Use of MCE Clavulanate potassium

In Vivo Efficacy Study

RT-PCR

: Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]; Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) did not change GLT-1 mRNA expression in the rat PFC.

: Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Dec 5:984:177017. [Abstract]; Clavulanic acid (CLAV, 10 mg/kg, injected twice daily for 7 days) increased expression of GLT-1 protein in the rat PFC.

: Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Average body weight at baseline and after treatment, by group. Two‑way ANOVA showed no significant differences between groups. n = 8–9 per group. Color dots represent individual data. CA (clavulanic acid, 5 mg/kg, i.p. for 7 days); DHK (dihydrokainic acid).

: Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Post hoc comparisons using Tukey’s test indicated the total time spent in closed arms to be higher in the Khat and Khat‑CA‑DHK (CA: clavulanic acid, 5 mg/kg, i.p. for 7 days) groups as compared with the Control and Khat‑CA groups.

: Clavulanate potassium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Oct 27;24(21):15657.; Clavulanic acid (5 mg/kg, i.p. for 7 days) reversed the Khat‑induced decrease in GLT‑1 and xCT expression in mice.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic^[1]^[2].

IC₅₀ & Target

β-lactam

In Vitro

Clavulanate potassium has weak antibacterial activity against most organisms when administered alone, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase^[1].
Clavulanate potassium (0.25 mg/L, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration (1 mg/L) is only marginally more effective than 0.5 mg/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

237.25

Formula

C₈H₈KNO₅

CAS No.

61177-45-5

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O[K]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.86%

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Data Sheet (272 KB) SDS (570 KB)

COA (250 KB) HNMR (214 KB) RP-HPLC (262 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11(5): 852–857. [Content Brief]

[2]. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23(4):547-56. [Content Brief]