2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MetAP

MetAP

Methionine Aminopeptidase

 

MetAP Related Products (12):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120868
    TP-004
    		Inhibitor 98.89%
    TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM.
    TP-004
  • HY-133016
    M8891
    		Inhibitor 98.97%
    M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.
    M8891
  • HY-128147
    MetAP2-IN-1
    		Inhibitor 99.55%
    MetAP2-IN-1 is a MetAP2 inhibitor. MetAP2-IN-1 can be used for research in conditions mediated by angiogenesis.
    MetAP2-IN-1
  • HY-114196
    Aclimostat
    		Inhibitor ≥98.0%
    Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells.
    Aclimostat
  • HY-14811
    Beloranib
    		Inhibitor
    Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.
    Beloranib
  • HY-158006
    SDX-7539
    		Inhibitor
    SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice.
    SDX-7539
  • HY-126564
    Ebelactone A
    		Inhibitor
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-P4344
    Met-Gly-Pro-AMC
    		Inhibitor 99.69%
    Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2.
    Met-Gly-Pro-AMC
  • HY-133016A
    (R)-M8891
    		Inhibitor 98.67%
    (R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor.
    (R)-M8891
  • HY-109188
    Relzomostat
    		Inhibitor
    Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions.
    Relzomostat
  • HY-148442
    ecMetAP-IN-1
    		Inhibitor
    ecMetAP-IN-1 (compound 17) is a potent ecMetAP inhibitor with an IC50 value of 2.086 µM.
    ecMetAP-IN-1
  • HY-13731
    PPI-2458
    		Inhibitor
    PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research.
    PPI-2458