Fumarranol
Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration.
For research use only. We do not sell to patients.
- CAS No.: 912569-37-0
- Formula: C16H24O4
- Molecular Weight:280.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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MetAp2 3.2 μM (IC50) |
Fumarranol (0-100 μM) selectively inhibits recombinant hMetAP2 enzymatic activity with an IC50 of 3.2 μM, and does not inhibit hMetAP1 at 100 μM[1].
Fumarranol inhibits bovine aortic endothelial cell proliferation with an IC50 of 34 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 912569-37-0
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Molecular Weight 280.36
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Formula C16H24O4
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SMILES
O(C)[C@]12[C@](CO)([C@]1([C@]3(C)[C@@H](CC=C(C)C)O3)[H])CCC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fumarranol Related Classifications
HY-133806 Related Classifications
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