912569-37-0
Chemical Structure
Fumarranol
- CAS. Nr.: 912569-37-0
- Formula:C16H24O4
- Molecular Weight:280.36
IUPAC Name: (1S,5S,6S)-5-(hydroxymethyl)-1-methoxy-6-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)bicyclo[3.1.0]hexan-2-one
InChIKey: CANZHCRPLGNWCR-LJIZCISZSA-N
SMILES: O(C)[C@]12[C@](CO)([C@]1([C@]3(C)[C@@H](CC=C(C)C)O3)[H])CCC2=O
Biological Activity: Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration[1].
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Fumarranol | Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration. | |||||||||||||||||||||
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Keywords
