2. Metabolic Enzyme/Protease
  3. MetAP
  4. CKD-731

CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer.

For research use only. We do not sell to patients.

CKD-731

CKD-731 Chemical Structure

CAS No. : 251111-15-6

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CKD-731 Related Antibodies

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Description

CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer[1].

Cellular Effect
Cell Line Type Value Description References
CPAE IC50
0.03 μg/mL
Compound: S10
Cytotoxic activity against cow CPAE cells by MTT assay
Cytotoxic activity against cow CPAE cells by MTT assay
[PMID: 31009908]
CPAE IC50
0.00003 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
[PMID: 10636239]
EL4 IC50
0.00015 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
[PMID: 10636239]
EL4 IC50
0.15 μg/mL
Compound: S10
Antitumor activity against mouse EL4 cells by MTT assay
Antitumor activity against mouse EL4 cells by MTT assay
[PMID: 31009908]
P388 IC50
> 1 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
[PMID: 10636239]
Molecular Weight

502.60

Formula

C28H38O8
CAS No.
SMILES

O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CKD-731 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CKD-731251111-15-6CKD731CKD 731MetAPMethionine Aminopeptidasecalf pulmonary artery endothelial cells (CPAE)lymphoma EL-4 cellsmurine leukemia P388D1 cellscancerInhibitorinhibitorinhibit

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