MetAP
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MetAP Related Products (12)
Related Products (12)
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M8891
0 ImagesM8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.
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Fumagilin-105
0 ImagesCat. No.: HY-161742CAS No.: 2410081-58-0Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121); target-binding ligand (HY-B0751); linker (HY-W245803)).
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(R)-M8891
0 Images(R)-M8891 is the low-activity isomer of M8891 (HY-133016). M8891 is an orally active, reversible, and blood-brain barrier-penetrant methionine aminopeptidase 2 (MetAP-2) inhibitor.
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Anticancer agent 51
0 ImagesCat. No.: HY-146396CAS No.: 2521777-38-6Anticancer agent 51 (compound 3d) is a potent anticancer agent with an Ki of 731.62 nM. Anticancer agent 51 shows anticancer activity. Anticancer agent 51 has the potential for the research of prostate cancer.
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SDX-7539
0 ImagesCat. No.: HY-158006CAS No.: 1631953-52-0SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice.
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Ebelactone A
0 ImagesEbelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
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SB-587094
0 ImagesCat. No.: HY-182482CAS No.: 949142-44-3SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research.
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YOK24
0 ImagesCat. No.: HY-181643CAS No.: 3075693-57-8
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NS-181
0 ImagesCat. No.: HY-181644CAS No.: 3075693-63-6NS-181 is an orally active MetAP2 inhibitor and antiamebic agent with oral effectiveness.NS-181 functionally inhibits methionine aminopeptidase 2, a protein critical for Entamoeba histolytica proliferation. NS-181 exerts antiamebic activity against Entamoeba histolytica, leading to resolution of amebic liver abscess. NS-181 can be used for the research of amebiasis.
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5-(2-Nitrophenyl)-2-furoic acid
0 ImagesCat. No.: HY-128073CAS No.: 29048-34-8Synonyms: O-Nitrophenylfuroic acid5-(2-Nitrophenyl)-2-furoic acid (O-Nitrophenylfuroic acid) is a Mn2+-form Escherichia coli methionine aminopeptidase (EcMetAP) inhibitor with an IC50 of 1.08 μM against Escherichia coli. 5-(2-Nitrophenyl)-2-furoic acid selectively inhibits the Mn2+-form over the Co2+-, Ni2+-, and Fe2+-forms of EcMetAP, with its carboxyl group preferentially coordinating with Mn2+ ions as the major determinant for this metalloform selectivity. 5-(2-Nitrophenyl)-2-furoic acid can be used for the research of bacterial infection.
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ecMetAP-IN-1
0 ImagesecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC50 of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli.
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