ecMetAP-IN-1

Cat. No.: HY-148442 Purity: 98.12%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC₅₀ of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli.

For research use only. We do not sell to patients.

ecMetAP-IN-1 Chemical Structure

CAS No. : 7471-12-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	7.7 μM Compound: 16	Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells	[PMID: 20621724]

In Vitro

ecMetAP-IN-1 (Compound 17) (45 min) inhibits Co^II-Loaded Escherichia coli methionine aminopeptidase with an IC₅₀ value of 2.086 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

209.25

Formula

C₁₃H₁₁N₃

CAS No.

7471-12-7

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (477.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7790 mL	23.8949 mL	47.7897 mL
5 mM	0.9558 mL	4.7790 mL	9.5579 mL
10 mM	0.4779 mL	2.3895 mL	4.7790 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.12%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB) HNMR (244 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Schiffmann R, et al. Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J Med Chem. 2006;49(2):511-522. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7790 mL	23.8949 mL	47.7897 mL	119.4743 mL
	5 mM	0.9558 mL	4.7790 mL	9.5579 mL	23.8949 mL
	10 mM	0.4779 mL	2.3895 mL	4.7790 mL	11.9474 mL
	15 mM	0.3186 mL	1.5930 mL	3.1860 mL	7.9650 mL
	20 mM	0.2389 mL	1.1947 mL	2.3895 mL	5.9737 mL
	25 mM	0.1912 mL	0.9558 mL	1.9116 mL	4.7790 mL
	30 mM	0.1593 mL	0.7965 mL	1.5930 mL	3.9825 mL
	40 mM	0.1195 mL	0.5974 mL	1.1947 mL	2.9869 mL
	50 mM	0.0956 mL	0.4779 mL	0.9558 mL	2.3895 mL
	60 mM	0.0796 mL	0.3982 mL	0.7965 mL	1.9912 mL
	80 mM	0.0597 mL	0.2987 mL	0.5974 mL	1.4934 mL
	100 mM	0.0478 mL	0.2389 mL	0.4779 mL	1.1947 mL

ecMetAP-IN-1 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ecMetAP-IN-17471-12-7MetAPBacterialMethionine AminopeptidaseEscherichia colimethionine aminopeptidasebacterial infectionInhibitorinhibitorinhibit

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