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Cat. No.: HY-128073

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5-(2-Nitrophenyl)-2-furoic acid

Name: 5-(2-Nitrophenyl)-2-furoic acid
Brand: MedChemExpress
SKU: HY-128073
Availability: PreOrder

(Synonyms: O-Nitrophenylfuroic acid)

5-(2-Nitrophenyl)-2-furoic acid (O-Nitrophenylfuroic acid) is a Mn²⁺-form Escherichia coli methionine aminopeptidase (EcMetAP) inhibitor with an IC₅₀ of 1.08 μM against Escherichia coli. 5-(2-Nitrophenyl)-2-furoic acid selectively inhibits the Mn²⁺-form over the Co²⁺-, Ni²⁺-, and Fe²⁺-forms of EcMetAP, with its carboxyl group preferentially coordinating with Mn²⁺ ions as the major determinant for this metalloform selectivity. 5-(2-Nitrophenyl)-2-furoic acid can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

CAS No.: 29048-34-8
Formula: C₁₁H₇NO₅
Molecular Weight:233.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5-(2-Nitrophenyl)-2-furoic acid Chemical Structure

CAS No.: 29048-34-8

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Biological Activity

Description

All MetAP Isoforms :

In Vitro

5-(2-Nitrophenyl)-2-furoic acid (Compound 20) selectively inhibits the Mn²⁺-bound form of Escherichia coli methionine aminopeptidase with an IC₅₀ of 1.08 μM, whereas its inhibitory activity against the Co²⁺-, Ni²⁺- and Fe²⁺-bound forms of the enzyme is much weaker, with IC₅₀ values of 120, 175 and 178 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 29048-34-8
Appearance Solid
Molecular Weight 233.18
Formula C₁₁H₇NO₅
SMILES

O=C(C1=CC=C(C2=CC=CC=C2[N+]([O-])=O)O1)O
Synonyms

O-Nitrophenylfuroic acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang QQ, et al. Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase. Bioorganic & medicinal chemistry letters. 2005 Dec 15;15(24):5386-91. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-(2-Nitrophenyl)-2-furoic acid

All MetAP Isoforms