29048-34-8
Chemical Structure
5-(2-Nitrophenyl)-2-furoic acid
Synonym(s): O-Nitrophenylfuroic acid
- CAS No.: 29048-34-8
- Formula:C11H7NO5
- Molecular Weight:233.18
IUPAC Name: 5-(2-nitrophenyl)furan-2-carboxylic acid
InChIKey: XUFDYUSOQQYQRL-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=CC=C2[N+]([O-])=O)O1)O
Biological Activity: 5-(2-Nitrophenyl)-2-furoic acid (O-Nitrophenylfuroic acid) is a Mn2+-form Escherichia coli methionine aminopeptidase (EcMetAP) inhibitor with an IC50 of 1.08 μM against Escherichia coli. 5-(2-Nitrophenyl)-2-furoic acid selectively inhibits the Mn2+-form over the Co2+-, Ni2+-, and Fe2+-forms of EcMetAP, with its carboxyl group preferentially coordinating with Mn2+ ions as the major determinant for this metalloform selectivity. 5-(2-Nitrophenyl)-2-furoic acid can be used for the research of bacterial infection[1].
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5-(2-Nitrophenyl)-2-furoic acid | 5-(2-Nitrophenyl)-2-furoic acid (O-Nitrophenylfuroic acid) is a Mn2+-form Escherichia coli methionine aminopeptidase (EcMetAP) inhibitor with an IC50 of 1.08 μM against Escherichia coli. 5-(2-Nitrophenyl)-2-furoic acid selectively inhibits the Mn2+-form over the Co2+-, Ni2+-, and Fe2+-forms of EcMetAP, with its carboxyl group preferentially coordinating with Mn2+ ions as the major determinant for this metalloform selectivity. 5-(2-Nitrophenyl)-2-furoic acid can be used for the research of bacterial infection. | |||||||||||||||||||||
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