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Cat. No.: HY-182482

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SB-587094

SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 949142-44-3
Formula: C₁₆H₁₈N₄S₂
Molecular Weight:330.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB-587094 Chemical Structure

CAS No.: 949142-44-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All MetAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	150 nM Compound: 102	Growth inhibition of HUVEC cells by XTT assay Growth inhibition of HUVEC cells by XTT assay	[PMID: 17636946]

In Vitro

SB-587094 (Thiophene 102) exhibits inhibitory activity against recombinant human cobalt-containing MetAP-2, with a K_i,app of 2 nM^[2].
SB-587094 inhibits recombinant human manganese-containing MetAP-2 with an apparent inhibition constant (K_i,app) of 1500 nM^[2].
SB-587094 (72 h) inhibits the proliferation of human umbilical vein endothelial cells with an IC₅₀ of 150 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 949142-44-3
Molecular Weight 330.47
Formula C₁₆H₁₈N₄S₂
SMILES

CC(C)C1=C(C=CC=C1)NC2=NN=C(SCC3=CC=CS3)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Heinrich T, et al. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem. 2019;62(10):5025-5039. [Content Brief]

[2]. Marino JP Jr, et al. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem. 2007;50(16):3777-3785. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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SB-587094

All MetAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SB-587094 Related Classifications

HY-182482 Related Classifications