949142-44-3
949142-44-3
Chemical Structure
SB-587094
- CAS No.: 949142-44-3
- Formula:C16H18N4S2
- Molecular Weight:330.47
InChIKey: QMNSHLAPQLBIGP-UHFFFAOYSA-N
SMILES: CC(C)C1=C(C=CC=C1)NC2=NN=C(SCC3=CC=CS3)N2
Biological Activity: SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research[1][2].
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SB-587094 | SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research. | |||||||||||||||||||||
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References
- [1]. Heinrich T, et al. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem. 2019;62(10):5025-5039. [Content Brief]
- [2]. Marino JP Jr, et al. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem. 2007;50(16):3777-3785. [Content Brief]
