Fumagilin-105
Based on 1 Customer Validation
Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121); target-binding ligand (HY-B0751); linker (HY-W245803)).
For research use only. We do not sell to patients.
- Purity: 97.34%
- CAS No.: 2410081-58-0
- Formula: C46H60N2O9
- Molecular Weight:784.98
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Fumagilin-105 (0-10 μM; 24 h) can effectively degrade MetAP2 in HEK293 cells with a DC50 of ~0.7 μM and a Dmax, 24 h of ~1-10 μM, and in U87-MG glioblastoma cells with a DC50 of ~500 nM[1].
Fumagilin-105 (5 μM; 0-24 h) can inhibit the migration of U87-MG glioblastoma cells[1].
Fumagilin-105 (1 μM; 48 h) can induce programmed cell death in HeLa cells, increasing the sub-G1 phase cell population[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87-MG and HEK293 cells
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Concentration:0, 0.5, 2.5 and 10 μM in U87-MG
0, 0.001, 0.01, 0.1, 1, 2.5, 5 and 10 μM in HEK293 -
Incubation Time:24 h
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Result:Inhibited the levels of MetAP2 in a dose-dependent manner.
Chemical Information
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CAS No. 2410081-58-0
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Appearance Solid
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Molecular Weight 784.98
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Formula C46H60N2O9
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Color Colorless to off-white
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SMILES
C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(/C=C/C=C/C=C/C=C/C(NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4)=O)=O)CO3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 63 mg/mL (80.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2739 mL | 6.3696 mL | 12.7392 mL | 31.8479 mL |
| 5 mM | 0.2548 mL | 1.2739 mL | 2.5478 mL | 6.3696 mL | |
| 10 mM | 0.1274 mL | 0.6370 mL | 1.2739 mL | 3.1848 mL | |
| 15 mM | 0.0849 mL | 0.4246 mL | 0.8493 mL | 2.1232 mL | |
| 20 mM | 0.0637 mL | 0.3185 mL | 0.6370 mL | 1.5924 mL | |
| 25 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2739 mL | |
| 30 mM | 0.0425 mL | 0.2123 mL | 0.4246 mL | 1.0616 mL | |
| 40 mM | 0.0318 mL | 0.1592 mL | 0.3185 mL | 0.7962 mL | |
| 50 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6370 mL | |
| 60 mM | 0.0212 mL | 0.1062 mL | 0.2123 mL | 0.5308 mL | |
| 80 mM | 0.0159 mL | 0.0796 mL | 0.1592 mL | 0.3981 mL |
Fumagilin-105 Related Classifications
HY-161742 Related Classifications
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