MetAP
Methionine Aminopeptidase
Methionine aminopeptidase (MetAP) is an enzyme that plays a crucial role in protein biosynthesis. MetAP is responsible for the removal of the N-terminal methionine residue from nascent polypeptide chains, which is essential for the proper folding, maturation and function of many proteins. MetAP1 and MetAP2 have different subcellular localizations and substrate specificities. MetAP1 is mainly involved in the processing of cytosolic proteins. MetAP2 is of particular interest in cancer research as it is involved in angiogenesis and has been targeted for anti-cancer drug development. Inhibition of MetAP2 can disrupt the growth and proliferation of cancer cells by interfering with the processing of certain proteins involved in angiogenesis[1][2].
MetAP Isoform Specific Products
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MetAP Related Products (29)
Related Products (29)
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MetAP Isoform Comparison
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JNJ-4929821
0 ImagesCat. No.: HY-122225CAS No.: 836671-12-6
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SDX-7539
0 ImagesCat. No.: HY-158006CAS No.: 1631953-52-0SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice.
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Ebelactone A
0 ImagesEbelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
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YOK24
0 ImagesCat. No.: HY-181643CAS No.: 3075693-57-8YOK24 is an orally active MetAP2 inhibitor and anti-amoebic agent. YOK24 binds covalently to MetAP2 and inhibits its peptidase activity, where MetAP2 is a protein essential for the proliferation of *Entamoeba histolytica*. YOK24 can be used in the research of amoebiasis.
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Anticancer agent 313
0 ImagesCat. No.: HY-182781Anticancer agent 313 is a MetAP2 inhibitor with an IC50 of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer.
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NS-181
0 ImagesCat. No.: HY-181644CAS No.: 3075693-63-6NS-181 is an orally active MetAP2 inhibitor and antiamebic agent with oral effectiveness.NS-181 functionally inhibits methionine aminopeptidase 2, a protein critical for Entamoeba histolytica proliferation. NS-181 exerts antiamebic activity against Entamoeba histolytica, leading to resolution of amebic liver abscess. NS-181 can be used for the research of amebiasis.
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Beloranib hemioxalate
0 ImagesCat. No.: HY-14811ACAS No.: 529511-79-3Synonyms: ZGN-440 hemioxalate; ZGN-433 hemioxalate; CDK732 hemioxalateBeloranib (ZGN-440; CKD-732 free base) hemioxalate is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib hemioxalate blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib hemioxalate significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib hemioxalate also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib hemioxalate can be used in research on obesity and hypothalamic obesity.
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5-(2-Nitrophenyl)-2-furoic acid
0 ImagesCat. No.: HY-128073CAS No.: 29048-34-8Synonyms: O-Nitrophenylfuroic acid5-(2-Nitrophenyl)-2-furoic acid (O-Nitrophenylfuroic acid) is a Mn2+-form Escherichia coli methionine aminopeptidase (EcMetAP) inhibitor with an IC50 of 1.08 μM against Escherichia coli. 5-(2-Nitrophenyl)-2-furoic acid selectively inhibits the Mn2+-form over the Co2+-, Ni2+-, and Fe2+-forms of EcMetAP, with its carboxyl group preferentially coordinating with Mn2+ ions as the major determinant for this metalloform selectivity. 5-(2-Nitrophenyl)-2-furoic acid can be used for the research of bacterial infection.
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ecMetAP-IN-1
0 ImagesecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC50 of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli.
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