JNJ-4929821
JNJ-4929821 is a selective methionine aminopeptidase type 2 (MetAP-2) inhibitor with an estimated IC50 value of 15 nM. JNJ-4929821 does not inhibit microvascular growth.
For research use only. We do not sell to patients.
- CAS No.: 836671-12-6
- Formula: C14H13FN4O2S2
- Molecular Weight:352.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
MetAp2 15 nM (IC50) |
MetAp1 |
In Vitro
JNJ-4929821 inhibits rhMetAP-2 with an IC50 of 25 nM[1] when the 14-3-3c N-terminal 8mer peptide is used as the substrate.
JNJ-4929821 (10 µM) shows good Caco-2 monolayer permeability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC
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Concentration:1.0 and 10 µM
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Incubation Time:24 h (starvation); 48 h (incubation); 24 h (BrdU)
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Result:LSGS-stimulated HUVEC proliferation was not significantly inhibited at 1.0 or 10 µM.
Chemical Information
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CAS No. 836671-12-6
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Molecular Weight 352.41
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Formula C14H13FN4O2S2
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SMILES
O=S(C1=CC=CS1)(N(CC2=CC=C(F)C=C2)CC3=NC=NN3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-4929821 Related Classifications
HY-122225 Related Classifications
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