MetAP Degrader
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BAY-277
0 Images製品番号: HY-168967BAY-277 is a selective METAP2 degrader and inhibitor. BAY-277 induces ubiquitination and proteasomal degradation of METAP2, triggers G1-phase cell cycle arrest, and inhibits angiogenesis and endothelial cell proliferation. BAY-277 serves as a chemical probe for investigating the biological functions of METAP2. BAY-277 is applicable to cancer-related research.
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Fumagilin-105
0 Images製品番号: HY-161742CAS 番号: 2410081-58-0Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121); target-binding ligand (HY-B0751); linker (HY-W245803)).
